Patents by Inventor Kanchana Rueksomtawin Kildegaard

Kanchana Rueksomtawin Kildegaard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND CELL FACTORIES FOR PRODUCING INSECT PHEROMONES
    Publication number: 20230332096
    Abstract: The present invention relates to pheromone production, desaturated fatty alcohols or aldehydes or acetates using recombinant yeasts expressing acyl-CoA oxidase to shorten fatty acyl-CoA by two carbons, deleting endogenous acyl-CoA oxidase, express desaturase to introduce at least one double bond, acyl-CoA-reductase to convert fatty acyl-CoA into fatty alcohol. Further, acetyltransferase can be used to convert to desaturated acyl fatty acetate, alcohol dehydrogenase or fatty acyl oxidase to convert to desaturated fatty aldehyde.
    Type: Application
    Filed: February 10, 2020
    Publication date: October 19, 2023
    Applicant: BioPhero ApS
    Inventors: Irina Borodina, Leonie Wenning, Carina Holkenbrink, Kanchana Rueksomtawin Kildegaard, Baojian Ding, Christer Löfstedt, Karolis Petkevicius
  • 3HP tolerance
    Patent number: 10077455
    Abstract: Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione-dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: September 18, 2018
    Assignee: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Kanchana Rueksomtawin Kildegaard, Irina Borodina, Jochen Förster, Jens Nielsen
  • Microbial production of 3-hydroxypropionic acid
    Patent number: 10066245
    Abstract: A yeast cell having a reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: September 4, 2018
    Assignee: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Niels Bjerg Jensen, Irina Borodina, Yun Chen, Jerome Maury, Kanchana Rueksomtawin Kildegaard, Jochen Förster, Jens Nielsen
  • Genetically engineered yeast
    Patent number: 9868966
    Abstract: A genetically modified Saccharomyces cerevisiae including an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalyzing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: January 16, 2018
    Assignee: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Irina Borodina, Kanchana Rueksomtawin Kildegaard, Jochen Förster, Fredrik Öberg
  • MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID
    Publication number: 20160138056
    Abstract: A yeast cell having a reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 19, 2016
    Applicant: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Niels Bjerg JENSEN, Irina BORODINA, Yun CHEN, Jerome MAURY, Kanchana Rueksomtawin KILDEGAARD, Jochen FÖRSTER, Jens NIELSEN
  • 3HP TOLERANCE
    Publication number: 20160130613
    Abstract: Cells and cell cultures are provided that have improved tolerance to 3-hydroxypropionic acid (3HP). Genetic modifications to provide a mutated or overexpressed SFA1 gene or other enhancement of 3HP detoxification via a glutathione-dependent dehydrogenase reaction, including medium supplementation with glutathione, may be combined with a 3HP producing metabolic pathway.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 12, 2016
    Applicant: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Kanchana Rueksomtawin KILDEGAARD, Irina BORODINA, Jochen FÖRSTER, Jens NIELSEN
  • GENETICALLY ENGINEERED YEAST
    Publication number: 20150267228
    Abstract: A genetically modified Saccharomyces cerevisiae including an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.
    Type: Application
    Filed: October 10, 2013
    Publication date: September 24, 2015
    Applicant: TECHNICAL UNIVERSITY OF DENMARK
    Inventors: Irina Borodina, Kanchana Rueksomtawin Kildegaard, Jochen Förster, Fredrik Öberg