Abstract: A system and method for detection of synthesized videos of humans. The method including: determining blood flow signals using a first machine learning model trained with a hemoglobin concentration (HC) changes training set, the first machine learning model taking as input bit values from a set of bitplanes in a captured image sequence, the HC changes training set including bit values from each bitplane of images captured from a set of subjects for which HC changes are known; determining whether blood flow patterns from the video are indicative of a synthesized video using a second machine learning model, the second machine learning model taking as input the blood flow signals, the second machine learning model trained using a blood flow training set including blood flow data signals from at least one of a plurality of videos of other human subjects for which it is known whether each video is synthesized.

Abstract: A bidet body that includes at least one of a drying nozzle and a cleaning nozzle moving in one of a forward and downward direction and an upward and backward direction, and a bottom surface of a cover that constitutes an exterior of the bidet body may be flat.

Abstract: Provided are systems and methods for determination of a concentration of one or more blood biomarkers of a human subject. The method including: determining, using a first machine learning model trained with a hemoglobin concentration (HC) changes training set, bit values from a set of bitplanes in a captured image sequence that represent the HC changes of the subject, the set of bitplanes being those that are determined to approximately maximize a signal-to-noise ratio (SNR), the HC changes training set including bit values from each bitplane of images captured from a set of subjects for which HC changes are known; determining, using a second machine learning model trained using a blood biomarkers training set, concentration of one or more blood biomarkers, the blood biomarkers training set including previously determined HC change signals from other subjects and one or more blood panels from those subjects as ground truth data.

Abstract: A system and method for detection of synthesized videos of humans. The method including: determining blood flow signals using a first machine learning model trained with a hemoglobin concentration (HC) changes training set, the first machine learning model taking as input bit values from a set of bitplanes in a captured image sequence, the HC changes training set including bit values from each bitplane of images captured from a set of subjects for which HC changes are known; determining whether blood flow patterns from the video are indicative of a synthesized video using a second machine learning model, the second machine learning model taking as input the blood flow signals, the second machine learning model trained using a blood flow training set including blood flow data signals from at least one of a plurality of videos of other human subjects for which it is known whether each video is synthesized.

Abstract: An electronic device includes a substrate, a sensor, a pressurizing component, and a stopping structure. The substrate has a bearing surface. The sensor is disposed on the bearing surface. The pressurizing component is disposed on the sensor. The stopping structure is disposed between the pressurizing component and the sensor. The stopping structure has opposite upper and lower surfaces and a plurality of openings, and each opening penetrates from the upper surface to the lower surface.

Abstract: The present invention relates to an artificially engineered CRISPR/Cas9 system. More particularly, the present invention relates to an artificially engineered CRISPR enzyme having enhanced target specificity and a use of an artificially engineered CRISPR/Cas9 system including the same enzyme in genome and/or epigenome manipulation or modification, genome targeting, genome editing, and in vitro diagnosis, etc.

Abstract: An electronic device including a substrate, a sensor, a partition wall structure, a pressurizing component, and a stopping structure is provided. The substrate has a carrying surface. The sensor is disposed on the carrying surface. The partition wall structure is disposed on the carrying surface and surrounds the sensor. The pressurizing component is disposed on the partition wall structure. The pressurizing component, the partition wall structure, and the substrate jointly form a cavity, and the pressurizing component includes a mass and a vibration membrane. The stopping structure is disposed between the pressurizing component and the partition wall structure and extends into the cavity. The stopping structure has at least one opening penetrating the stopping structure.

Abstract: A vibration sensor is designed to have a pressure-enhancing member, a pressure sensing device and first, second, third chambers. An air gap is designed to enable the first chamber to be vented to the third chamber such that the first chamber is combined with the third chamber to obtain a communicable air volume. An adhesive layer is formed between a spacer and a circuit board, and the air gap is formed in an adhesive-absent section between the spacer and the circuit board. When the pressure-enhancing member is moved to squeeze the air in the second chamber, a sensitivity of the pressure sensing device will be greatly improved.

Abstract: The present application relates to cells having high adaptability under hypoxic conditions and to a preparation method therefor. Particularly, the present disclosure provides cells having high adaptability under hypoxic conditions, the cells including at least one engineered gene having an indel within a wild-type gene selected from the group consisting of HIF1AN, HIF3A, PHD2, TLR4 and PAI1. In addition, the present disclosure provides, as a method for preparing cells having high adaptability under hypoxic conditions, a gene editing method including introducing a CRISPR/Cas9 system into cells.

Abstract: The present disclosure provides a pharmaceutical composition for treating Alzheimer's disease and use thereof, the pharmaceutical composition containing, as an active ingredient, stem cells (SC) having high adaptability under hypoxic conditions. Particularly, the present disclosure discloses a pharmaceutical composition for alleviating or treating the symptoms of Alzheimer's disease, the pharmaceutical composition containing, as an active ingredient, mesenchymal stem cells (MSC) which have high adaptability or viability in hypoxic environments and comprise one or more knock-out HIF1AN genes.

Abstract: The present invention relates to a process for preparing an isoindolinone derivative represented by Formula 1, novel intermediates used for the process and a process for preparing the intermediates.

Abstract: A vibration sensing assembly, including a base, a side shell, a sensor, an upper cover, and a diaphragm assembly, is provided. The base includes first and second bottom plates. A first cavity is formed between the first and second bottom plates. The second bottom plate includes first and second through holes. The side shell is disposed on the second bottom plate and includes a cylinder and an inner partition. The inner partition divides the cylinder into a second cavity and an airflow channel. The airflow channel is communicated with the first cavity through the first through hole. The sensor is disposed in the second cavity and covers the second through hole. The side shell is located between the base and the upper cover. The base, the side shell, and the upper cover jointly form an outer shell. The diaphragm assembly is disposed between the side shell and the upper cover.

Abstract: A system and method for camera-based stress determination. The method includes: determining a plurality of regions-of-interest (ROIs) of a body part; determining a set of bitplanes in a captured image sequence for each ROI that represent HC changes using a trained machine learning model, the machine learning model trained with a hemoglobin concentration (HC) changes training set, the HC changes training set trained using bitplanes from previously captured image sequences of other human individuals as input and received cardiovascular data as targets; determining an HC change signal for each of the ROIs based on changes in the set of determined bitplanes; for each ROI, determining intervals between heartbeats based on peaks in the HC change signal; determining heart rate variability using the intervals between heartbeats; determining a stress level using at least one determination of a standard deviation of the heart rate variability; and outputting the stress level.

Abstract: A vibration sensing assembly, including a base, a side shell, a sensor, an upper cover, and a diaphragm assembly, is provided. The base includes first and second bottom plates. A first cavity is formed between the first and second bottom plates. The second bottom plate includes first and second through holes. The side shell is disposed on the second bottom plate and includes a cylinder and an inner partition. The inner partition divides the cylinder into a second cavity and an airflow channel. The airflow channel is communicated with the first cavity through the first through hole. The sensor is disposed in the second cavity and covers the second through hole. The side shell is located between the base and the upper cover. The base, the side shell, and the upper cover jointly form an outer shell. The diaphragm assembly is disposed between the side shell and the upper cover.

Abstract: A micro-electro mechanical device includes a casing, a vibration sensor, a vibration membrane assembly, and a micro-electro mechanical microphone. The casing has a sound-receiving hole, and the vibration sensor is disposed in the casing. The vibration membrane assembly is disposed in the casing and corresponds to the vibration sensor. The micro-electro mechanical microphone is disposed in the casing and corresponds to the sound-receiving hole, and a back cavity of the micro-electro mechanical microphone is formed in the casing. The back cavity at least partially overlaps with areas corresponding to a vertical projection of the vibration membrane assembly.

Abstract: The present disclosure relates to a media broadcasting system, including a first broadcasting device, a second broadcasting device and a processing device. The first broadcasting device and the second broadcasting device are respectively arranged at a first side and a second side of the media broadcasting system. The processing device is electrically coupled to the first broadcasting device and the second broadcasting device, and is configured to receive a media. The processing device is configured to obtain a first channel audio signal and a second channel audio signal from the media according to a first position parameter corresponding to the first broadcasting device and a second position parameter corresponding to the second broadcasting device. The processing device is further configured to transmit the first channel audio signal to the first broadcasting device and the second channel audio signal to the second broadcasting device.

Abstract: Systems and methods for time control for a data interface between a source device and a receiving device are provided. In one example, a method can include performing a capture time sweep process at the receiving device. The capture time sweep process includes performing a plurality of test data transfers at the receiving device at a plurality of different capture time settings. The method can include determining a capture time window based at least in part on the capture time sweep process. The capture time window can be defined as a duration between a first capture time and a second capture time. The method can include determining a selected capture time between the first capture time and the second capture time. The method can include controlling data transfer across the data interface based at least in part on the selected capture time.

Abstract: A system and method for health diagnostics and more specifically to an image-capture based system and method for detecting physiological state for a subject. The system provides a remote and non-invasive approach by which to detect physiological state with a high confidence. The system enables monitoring of hemoglobin concentration changes by optical imaging and related detection systems.

Abstract: A system and method for camera-based stress determination. The method includes: determining a plurality of regions-of-interest (ROIs) of a body part; determining a set of bitplanes in a captured image sequence for each ROI that represent HC changes using a trained machine learning model, the machine learning model trained with a hemoglobin concentration (HC) changes training set, the HC changes training set trained using bitplanes from previously captured image sequences of other human individuals as input and received cardiovascular data as targets; determining an HC change signal for each of the ROIs based on changes in the set of determined bitplanes; for each ROI, determining intervals between heartbeats based on peaks in the HC change signal; determining heart rate variability using the intervals between heartbeats; determining a stress level using at least one determination of a standard deviation of the heart rate variability; and outputting the stress level.

Abstract: A vibration sensor is designed to have a pressure-enhancing member, a pressure sensing device and first, second, third chambers. A first through hole is designed to enable the first chamber to be vented to the third chamber such that the first chamber is combined with the third chamber to obtain a communicable air volume. When the pressure-enhancing member is moved to squeeze the air in the second chamber, a sensitivity of the pressure sensing device will be greatly improved.