Abstract: A cell mass-forming member that is capable of easily forming a cell mass and superior in industrial mass productivity; a culture container equipped with the cell mass-forming member; a method for producing cultured cells using the cell mass-forming member; and cultured cells with a cell mass-forming member that are equipped with the cell mass-forming member. The cell mass-forming member has a base material, an adhesion inhibition area and a cell adhesion area are formed on the surface of the base material; a micro-concavo-convex structure area including a plurality of convex portions is formed in the cell adhesion area; and a hydrophilic coating layer is formed on both the adhesion inhibition area and the cell adhesion area. The culture container and the cultured cells with a cell mass-forming member are equipped with the cell mass-forming member. The method for producing cultured cells includes using the cell mass-forming member.

Abstract: A method for producing a cancer cell aggregate having certain properties, screening a drug for preventing and/or treating cancer, and determining anoikis resistance in epithelial cancer cells. The method includes culturing cells using a cell culture substrate having a base material and a biocompatible polymer layer. The cell culture substrate has rough sections not covered with the biocompatible polymer layer on the surface of the cell culture substrate. Each of the rough sections has a shape of a spot with a diameter of 20-100 ?m, or a groove with a width of 3-30 ?m with an end part of the rough section being optionally connected to another rough section. A distance between two adjacent rough sections is at least 10 ?m or more, and the rough section has an uneven structure with a height ranging from 20 nm to 200 nm on the surface.

Abstract: [Problem] An object of the present invention is to produce cancer cell clusters with intrinsic biological properties as cancer tissues, such as morphological polarity and tissue motion polarity, in vitro. [Solution] The present invention relates to a cell culture substrate including a base material and a biocompatible polymer layer, the substrate including a plurality of rough sections on the surface of the substrate, wherein the rough sections are not covered with the biocompatible polymer layer, have a predetermined surface structure with a predetermined shape, and are disposed at predetermined intervals. With the present invention, it is possible to obtain a live cancer cell aggregate having morphological polarity and tissue motion polarity similar to that observed in vivo, by a very easy operation of culturing cancer cells on a cell culture substrate having a predetermined structure, thereby performing live imaging of microtumors in vitro is enabled, which has been conventionally impossible.

Abstract: [Problem] An object of the present invention is to produce cancer cell clusters with intrinsic biological properties as cancer tissues, such as morphological polarity and tissue motion polarity, in vitro. [Solution] The present invention relates to a cell culture substrate including a base material and a biocompatible polymer layer, the substrate including a plurality of rough sections on the surface of the substrate, wherein the rough sections are not covered with the biocompatible polymer layer, have a predetermined surface structure with a predetermined shape, and are disposed at predetermined intervals. With the present invention, it is possible to obtain a live cancer cell aggregate having morphological polarity and tissue motion polarity similar to that observed in vivo, by a very easy operation of culturing cancer cells on a cell culture substrate having a predetermined structure, thereby performing live imaging of microtumors in vitro is enabled, which has been conventionally impossible.

Abstract: Foldable tubular construct/element with one rigid degree of freedom is of a tubular construction formed by a number of single layered annular units which are connected in sequence; each single layered annular unit is of a prism having N ridge lines; two adjacent prisms each having N sides are connected to each other by sharing a polygon with N sides formed on an intersection plane; each prism with N ridge lines is composed of N rigid planar quadrilateral facets; two adjacent single layered annular units comprise N spherical mechanisms formed by the intersections of only four planar quadrilateral facets at each apex, where N is a number greater than 3.

Abstract: A foldable tubular construct/element with one rigid degree of freedom is of a tubular construction formed by a number of single layered annular units which are connected in sequence; each single layered annular unit is of a prism having N ridge lines; two adjacent prisms each having N sides are connected to each other by sharing a polygon with N sides formed on an intersection plane; each prism with N ridge lines is composed of N rigid planar quadrilateral facets; two adjacent single layered annular units comprise N spherical mechanisms formed by the intersections of only four planar quadrilateral facets at each apex; the polygon having N sides formed in the intersection plane of the two adjacent single layered annular units is a planar polygon with an arbitrary number of sides greater than for a triangle; the ridge lines of each prism having N ridge lines are parallel to each other; the connecting ridge lines of the tubular element are coplanar; when the polygon having N sides formed in the intersection plan

Abstract: A foldable tubular construct/element with one rigid degree of freedom is of a tubular construction formed by a number of single layered annular units which are connected in sequence; each single layered annular unit is of a prism having N ridge lines; two adjacent prisms each having N sides are connected to each other by sharing a polygon with N sides formed on an intersection plane; each prism with N ridge lines is composed of N rigid planar quadrilateral facets; two adjacent single layered annular units comprise N spherical mechanisms formed by the intersections of only four planar quadrilateral facets at each apex; the polygon having N sides formed in the intersection plane of the two adjacent single layered annular units is a planar polygon with an arbitrary number of sides greater than for a triangle; the ridge lines of each prism having N ridge lines are parallel to each other; the connecting ridge lines of the tubular element are coplanar; when the polygon having N sides formed in the intersection plan