Abstract: A method for analyzing an image of a tissue section may include obtaining a plurality of image locations, each corresponding to a different one of a plurality of biological structures; obtaining a plurality of locations of a first biomarker in the image; and calculating a distance transform array for at least a portion of the image that includes the plurality of seed locations. The method may include, for each of the plurality of seed locations and based on information from the first distance transform array, detecting whether the first biomarker is expressed at the seed location, and storing, to a data structure associated with the seed location, an indication of whether expression of the first biomarker at the seed location was detected. The method may include detecting, based on the stored indications, co-localization of at least two phenotypes in at least a portion of the tissue section.

Abstract: An arrangement and a method for maximum intensity projection of a three-dimensional scene on a two dimensional display (11), via the calculation of first or higher-order interpolated values of points (P.sub.1, . . . , P.sub.m) along rays (61) casted through a voxel representation (50) of said scene avoids unnecessary interpolation operations by, firstly, determining an estimated minimum value for each ray (61) under consideration and for each sample point (P.sub.k) an estimated maximum value for the interpolated value. Only if the estimated maximum value for a point exceeds the estimated minimum value for the ray (61), an interpolation is required. Both estimated extremes are obtained by comparing the values contributing to the interpolations, the estimated minimum value by an analog procedure or by reference to a neighboring ray.

Abstract: Images formed by digital subtraction angiography are improved by subtracting a locally deformed image from another image. A subtraction image is obtained which is substantially free from motion artefacts and which contains only the information of a moving contrast medium. To achieve this, a shift vector is determined for various pixels and a reliability criterion is calculated for each direction component of said shift vector.