Patents by Inventor Karen Bush

Karen Bush has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-thiosubstituted carbapenems
    Patent number: 5750735
    Abstract: Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri-substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, processes for preparing the compounds and new intermediates useful in the process.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: May 12, 1998
    Assignee: American Cyanamid Company
    Inventors: Yang-I Lin, Panayota Bitha, Subas Sakya, Timothy W. Strohmeyer, Karen Bush, Carl Bernard Ziegler, Gregg Brian Feigelson
  • Method of inhibiting a .beta.-lactamase enzyme by administering novel 2-thiosubstituted carbapenems
    Patent number: 5744465
    Abstract: Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, method of inhibiting a Beta-lactamase enzyme by administering said compounds, processes for preparing the compounds and new intermediates useful in the process are disclosed.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: April 28, 1998
    Assignee: American Cyanamid Company
    Inventors: Yang-I Lin, Panayota Bitha, Subas Sakya, Timothy W. Strohmeyer, Karen Bush, Carl Bernard Ziegler, Gregg Brian Feigelson
  • Method for producing tetrahydrofuranyl compounds
    Patent number: 5623081
    Abstract: Tetrahydrofuanyl compounds of the following formulae: ##STR1## are disclosed.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: April 22, 1997
    Inventors: Yang-I Lin, Panayota Bitha, Subas Sakya, Timothy W. Strohmeyer, Karen Bush, Carl B. Ziegler, Gregg B. Feigelson
  • 2-thiosubstituted carbapenems
    Patent number: 5602118
    Abstract: Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, processes for preparing the compounds and new intermediates useful in the process.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: February 11, 1997
    Assignee: American Cyanamid Company
    Inventors: Yang-I Lin, Panayota Bitha, Subas Sakya, Timothy W. Strohmeyer, Karen Bush, Carl B. Ziegler, Gregg B. Feigelson
  • Process for preparing 6-[(isoxazolinyl)methyl]penicillanic acid 1,1-dioxide compounds
    Patent number: 5488106
    Abstract: The invention provides a novel class of 6-(isoxazolinyl)methyl penicillanic acid 1,1-dioxide compounds having the formula: ##STR1## wherein M, X, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are described in the specification;which exhibit activity as a .beta.-lactamase inhibitor.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: January 30, 1996
    Assignee: American Cyanamid Company
    Inventors: Carl Ziegler, Paul Fabio, Karen Bush, Deborah Steinberg
  • Phenazine ACE inhibitor produced from streptomyces species
    Patent number: 4568675
    Abstract: 3,6-Dihydroxyphenazine-1-carboxylic acid, a hypotensive agent, and its production by culturing aerobically Streptomyces species A.T.C.C. No. 39460 are disclosed herein.
    Type: Grant
    Filed: December 19, 1983
    Date of Patent: February 4, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karen Bush, Dorothy S. Slusarchyk, Wen-Chih Liu
  • ACE inhibitors produced from Nocardia orientalis
    Patent number: 4474693
    Abstract: N.sup.2 -[N-(N-acetylmuramoyl)-L-alanyl]-N-(5,6-diamino-1-carboxy-6-oxohexyl)-D-.a lpha.-glutamine, N.sup.2 -[N-(N-acetylmuramoyl)-L-alanyl]-N-[5,6-diamino-1-[[1-[(1-carboxyethyl)car bamoyl]ethyl]carbamoyl]-6-oxohexyl]-D-.alpha.-glutamine and EM5556C are obtained as a mixture by cultivating a strain of the microorganism Nocardia orientalis A.T.C.C. No. 39444.
    Type: Grant
    Filed: October 31, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Pushpa Singh, Karen Bush, Dorothy S. Slusarchyk