Abstract: Methods for treating a solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

Abstract: Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease. Also provided here in are methods of using such macrocycles in combination with at least one additional pharmaceutically active agent for treatment of disorders, for example for treatment of cancer.

Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

Abstract: Provided herein are novel proppants for use in hydraulic fracturing. The proppant has a core substrate and a light-weight substrate. The light weight substrate comprises a plurality of composite particles; a filler material; and an adhesive. The filler material has a particle-distribution-size of about 5 percent to about 20 percent of the particle-distribution-size of the plurality of composite particles. Additional additives can be optionally added to light-weight substrate. The adhesive binds the light-weight substrate to the core substrate to produce the proppant having a specific gravity of about 1 g/cc. Proppant can travel with the carrier fluid in a frac fluid rather than settling out quickly or floating away.

Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a liquid cancer, determined to lack a p53 deactivation mutation, in a subject.

Abstract: Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a liquid cancer, determined to lack a p53 deactivation mutation, in a subject.

Abstract: The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

Abstract: Provided herein are novel proppants for use in hydraulic fracturing. The proppant has a core substrate and a light-weight substrate. The light weight substrate comprises a plurality of composite particles; a filler material; and an adhesive. The filler material has a particle-distribution-size of about 5 percent to about 20 percent of the particle-distribution-size of the plurality of composite particles. Additional additives can be optionally added to light-weight substrate. The adhesive binds the light-weight substrate to the core substrate to produce the proppant having a specific gravity of about 1 g/cc. Proppant can travel with the carrier fluid in a frac fluid rather than settling out quickly or floating away.

Abstract: Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease. Also provided here in are methods of using such macrocycles in combination with at least one additional pharmaceutically active agent for treatment of disorders, for example for treatment of cancer.

Abstract: Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a liquid cancer, determined to lack a p53 deactivation mutation, in a subject.

Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.

Abstract: A completion assembly useful to fracture pack, gravel pack or otherwise treat production intervals traversed by an uncased wellbore is presented. The completion assembly may be used to stimulate production and/or prevent production of solid particles from the production intervals. A single trip method to fracture pack, gravel pack or otherwise treat multiple zones in an open-hole wellbore is disclosed where the wellbore has no liner or casing string installed through a production open hole portion.

Abstract: A completion assembly useful to fracture pack, gravel pack or otherwise treat production intervals traversed by an uncased wellbore to stimulate production and/or prevent production of solid particles from the production intervals and a single trip method to fracture pack, gravel pack or otherwise treat multiple zones in an open-hole wellbore having no liner or casing string installed through a production open hole portion.

Abstract: A floodlight configured to illuminate a controlled area includes a planar linkage assembly providing the lamp head of the floodlight with smooth oscillatory motion.