Abstract: The invention provides novel biparatopic LRP5/LRP6 cross-reactive binding polypeptides, and more specifically novel biparatopic LRP5/LRP6 cross-reactive immunoglobulin single variable domain constructs which can inhibit Wnt signaling pathways. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as cancer.

Abstract: A new cooler/icebox organizer keeps items cold, contained, separated, and easily accessible. The organizer includes an ice guard that attaches to the inside of a cooler or ice box and an organizing unit that slides into and out of the ice guard. Ice is stored in the cooler outside of the ice guard, along with drinks or other items that are easily located in ice and can have direct contact with ice and melt water. The organizing unit has a storage area for holding items that do not need direct ice contact, which is accessible without withdrawing the organizing unit. A second storage area can contain ice and items that need direct ice contact and is accessible when the organizing unit is withdrawn from the ice guard. The organizer can be used with existing coolers, makes items more easily accessible, and stays cool longer.