Abstract: A thermoplastic film which exhibits elastic-like behavior along at least one axis when stretched or elongated and then released. The thermoplastic film comprises a plurality of raised rib-like elements extending in a direction perpendicular to a main surface of the thermoplastic film. The thermoplastic film further includes a plurality of web areas positioned about the plurality of raised rib-like elements. The plurality of raised rib-like elements and plurality of web areas are arranged in a complex pattern. The complex pattern provides visual and tactile cues as the films are stretched or elongated. The complex pattern can cause the thermoplastic film to have a complex stretch profile.

Abstract: The present invention is directed to human monoclonal antibodies that bind to the cell-surface receptor, PD-1 (programmed death 1). The antibodies can be used to treat cancer and chronic viral infections.

Abstract: The present invention provides compositions and methods for augmenting antibody mediate receptor signaling.

Abstract: The present invention comprises human monoclonal antibodies that bind to GITR (also known as glucocorticoid-induced tumor necrosis factor receptor). Binding of the invented antibody to GITR inhibits binding of its ligand, GITR-L, and can be used to treat cancer.

Abstract: This invention is directed to chimeric antigen receptors and cells comprising the same, wherein the cells further secrete monoclonal antibodies locally at a tumor site.

Abstract: The present invention comprises human monoclonal antibodies that bind to GITR (also known as glucocorticoid-induced tumor necrosis factor receptor). Binding of the invented antibody to GITR inhibits binding of its ligand, GITR-L, and can be used to treat cancer.

Abstract: This invention is directed to engineered cells and methods for using the same. In embodiments, the engineered cell comprises a nucleic acid encoding a chimeric antigen receptor and a polypeptide, wherein the chimeric antigen receptor is specific for two or more antigens on the surface of a cancer cell, and wherein the polypeptide comprises an antibody or fragment thereof that can be secreted from the engineered cell.

Abstract: The present invention comprises human monoclonal antibodies that bind to GITR (also known as glucocorticoid-induced tumor necrosis factor receptor). Binding of the invented antibody to GITR inhibits binding of its ligand, GITR-L, and can be used to treat cancer.

Abstract: The present invention provides compositions and methods for augmenting antibody mediate receptor signaling.

Abstract: A gate bracket is formed of a planar web in which two rectangular portions along two edges of the web are bent to define a first pair of perpendicular flanges, and two other rectangular portions are bent from an inner portion of the web to form a second pair of perpendicular flanges. The flanges of the first pair are spaced from the flanges of the second pair by a distance corresponding to the dimensions of the structural members used to construct the gate. The invention provides a rigid bracket of simpler and lighter construction than prior art brackets.

Abstract: A gate bracket is formed of a planar web in which two rectangular portions along two edges of the web are bent to define a first pair of perpendicular flanges, and two other rectangular portions are bent from an inner portion of the web to form a second pair of perpendicular flanges. The flanges of the first pair are spaced from the flanges of the second pair by a distance corresponding to the dimensions of the structural members used to construct the gate. The invention provides a rigid bracket of simpler and lighter construction than prior art brackets.

Abstract: A hanger for mounting a gutter to a structure with a fastener. The hanger may include a bracket arm having first and second ends and extend widthwise to the gutter. A raised fastener guide portion may be connected to the first end of the bracket for delivery of the fastener. An outside gutter engagement device connected to the second end of the bracket arm for engaging the outside wall of the gutter and an inside gutter engagement device connected to the fastener guide portion for engaging the inside wall of the gutter and for receiving the fastener to mount the gutter to the structure may also be provided. A support arm may also be provided having first and second ends. The first end may be connected to the raised fastener guide portion and the second end of the support arm may abut the inside wall of the gutter when the hanger is attached to the gutter.

Abstract: A hanger for mounting a gutter to a structure with a fastener. The hanger may include a bracket arm having first and second ends and extend widthwise to the gutter. A raised fastener guide portion may be connected to the first end of the bracket for delivery of the fastener. An outside gutter engagement device connected to the second end of the bracket arm for engaging the outside wall of the gutter and an inside gutter engagement device connected to the fastener guide portion for engaging the inside wall of the gutter and for receiving the fastener to mount the gutter to the structure may also be provided. A support arm may also be provided having first and second ends. The first end may be connected to the raised fastener guide portion and the second end of the support arm may abut the inside wall of the gutter when the hanger is attached to the gutter.