Patents by Inventor Kari Kataja
Kari Kataja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9416401Abstract: The invention is related to a method and test kits for quantitative determination of polynucleotide amounts present in a sample. The test kit comprises organized pools with polynucleotide probes having distinct sizes and optionally provided with tracer tags or primer tags. The probes are allowed to hybridize with affinity tagged analyte polynucleotides from the sample. The result is hybrids, which can be recovered on a separation aiding tool provided with the pair of the affinity tag. After the quantitative release of the probes, the probes are either directly recorded, or if primer tagged, they are amplified and optionally provided with a tracer tag before recording. The invention provides a sensitive and quantitative determination of the amount polynucleotides present in a cell or tissue sample and allows a quantitative assessment of variations in the amounts of polynucleotides as a response to inherent changes or due to external stimuli.Type: GrantFiled: January 10, 2002Date of Patent: August 16, 2016Assignee: VALTION TEKNILLINEN TUTKIMUSKESKUSInventors: Hans Söderlund, Kari Kataja, Marja Paloheimo, Marja Ilmen, Kristiina Takkinen
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Patent number: 8895292Abstract: A microfluidic chip device (MCD) and its use for performing miniaturized assays on magnetic microbeads (MMs) are described. The MCD is particularly useful for carrying out miniaturized transcript analysis by aiding affinity capturing (TRAC) assays, including PCR. The MCD comprises at least one reaction chamber with sealable liquid connections and at least one fluidic pillar filter in each chamber. The fluidic pillar filter comprises rods with spacings allowing MMs to pass. The sealable liquid connections feed liquid to the reaction chamber, wherein air bubbles are removed. The liquid stream contacts the MMs, which are manipulated with a magnetic rod. The liquid connections enable trapping of the MMs behind the pillar filters or in the channel, while the liquid is changed.Type: GrantFiled: April 9, 2009Date of Patent: November 25, 2014Assignee: Valtion Teknillinen TutkimuskeskusInventors: Hans Söderlund, Ari Hokkanen, Kari Kataja, Ingmar Stuns, Kai Kolari, Heli Siren, Stella Rovio, Reetta Satokari, Jan Rautio
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Patent number: 8159668Abstract: An optical or infrared spectrometer is suitable for on-line measurements for industrial, agricultural, field, commercial and other applications. Optical spectrometers are very useful for various analytical measurements. On-line operation is needed for obtaining real-time information, which is useful e.g. for process automation and quality control needs. The invention is based on optical design optimized for measuring moving samples at a distance and includes a light guide for signal homogenization, a linear variable filter for defining multiple measurement wavelengths as well as a linear detector array for detecting optical signals relating to the different wavelengths. There is an element for cooling and stabilizing the operating temperature of both the linear detector array and the linear variable filter, while the spectrometer is operating in variable environmental conditions.Type: GrantFiled: September 3, 2008Date of Patent: April 17, 2012Assignees: Valtion teknillinen tutkimuskeskus, Honeywell OyInventors: Jouko Malinen, Kari Kataja, Sini Kivi, Hannu Vasama, Reijo Kuusela
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Patent number: 8143388Abstract: The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic variations in a mixed population of organisms using affinity aided solution hybridization. The test kit comprises organized pools of polynucleotide probes having approximately the same number of nucleotides, which are distinguishable using resolution enabling tags providing the probes with different sizes. The resolution enabling tags may simultaneously act as tracer, affinity or primer tags. The probes are allowed to hybridize with affinity tagged analyte polynucleotides. The result is hybrids, recoverable on separation aiding tools provided with counterparts of the affinity tag. After the quantitative release of the probes, the individual probes can be amplified and recorded.Type: GrantFiled: April 18, 2008Date of Patent: March 27, 2012Assignee: Valtion Teknillinen TutkimuskeskusInventors: Hans Söderlund, Reetta Satokari, Kari Kataja, Kristiina Takkinen
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Publication number: 20100284005Abstract: An optical or infrared spectrometer is suitable for on-line measurements for industrial, agricultural, field, commercial and other applications. Optical spectrometers are very useful for various analytical measurements. On-line operation is needed for obtaining real-time information, which is useful e.g. for process automation and quality control needs. The invention is based on optical design optimized for measuring moving samples at a distance and includes a light guide for signal homogenization, a linear variable filter for defining multiple measurement wavelengths as well as a linear detector array for detecting optical signals relating to the different wavelengths. There is an element for cooling and stabilizing the operating temperature of both the linear detector array and the linear variable filter, while the spectrometer is operating in variable environmental conditions.Type: ApplicationFiled: September 3, 2008Publication date: November 11, 2010Applicants: VALTION TEKNILLINEN TUTKIMUSKESKUS, HONEYWELL OYInventors: Jouko Malinen, Kari Kataja, Sini Kivi, Hannu Vasama, Reijo Kuusela
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Publication number: 20090269767Abstract: A microfluidic chip device (MCD) and its use for performing miniaturized assays on magnetic microbeads (MMs) are described. The MCD is particularly useful for carrying out miniaturized transcript analysis by aiding affinity capturing (TRAC) assays, including PCR. The MCD comprises at least one reaction chamber with sealable liquid connections and at least one fluidic pillar filter in each chamber. The fluidic pillar filter comprises rods with spacings allowing MMs to pass. The sealable liquid connections feed liquid to the reaction chamber, wherein air bubbles are removed. The liquid stream contacts the MMs, which are manipulated with a magnetic rod. The liquid connections enable trapping of the MMs behind the pillar filters or in the channel, while the liquid is changed.Type: ApplicationFiled: April 9, 2009Publication date: October 29, 2009Applicant: c/o Valtion teknillinen tutkimuskeskusInventors: Hans SODERLUND, Ari Hokkanen, Kari Kataja, Ingmar Stuns, Kai Kolari, Heli Siren, Stella Rovio, Reetta Satokari, Jari Rautio
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Publication number: 20080233591Abstract: The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic variations in a mixed population of organisms using affinity aided solution hybridization. The test kit comprises organized pools of polynucleotide probes having approximately the same number of nucleotides, which are distinguishable using resolution enabling tags providing the probes with different sizes. The resolution enabling tags may simultaneously act as tracer, affinity or primer tags. The probes are allowed to hybridize with affinity tagged analyte polynucleotides. The result is hybrids, recoverable on separation aiding tools provided with counterparts of the affinity tag. After the quantitative release of the probes, the individual probes can be amplified and recorded.Type: ApplicationFiled: April 18, 2008Publication date: September 25, 2008Inventors: Hans SODERLUND, Reetta Satokari, Kari Kataja, Kristiina Takkinen
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Patent number: 7361461Abstract: The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic variations in a mixed population of organisms using affinity aided solution hybridization. The test kit comprises organized pools of polynucleotide probes having approximately the same number of nucleotides, which are distinguishable using resolution enabling tags providing the probes with different sizes. The resolution enabling tags may simultaneously act as tracer, affinity or primer tags. The probes are allowed to hybridize with affinity tagged analyte polynucleotides. The result is hybrids, recoverable on separation aiding tools provided with counterparts of the affinity tag. After the quantitative release of the probes, the individual probes can be amplified and recorded.Type: GrantFiled: July 4, 2003Date of Patent: April 22, 2008Assignee: Valtion Teknillinen TutkimuskeskusInventors: Hans Söderlund, Reetta Satokari, Kari Kataja, Kristiina Takkinen
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Publication number: 20060035228Abstract: The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic variations in a mixed population of organisms using affinity aided solution hybridization. The test kit comprises organized pools of polynucleotide probes having approximately the same number of nucleotides, which are distinguishable using resolution enabling tags providing the probes with different sizes. The resolution enabling tags may simultaneously act as tracer, affinity or primer tags. The probes are allowed to hybridize with affinity tagged analyte polynucleotides. The result is hybrids, recoverable on separation aiding tools provided with counterparts of the affinity tag. After the quantitative release of the probes, the individual probes can be amplified and recorded.Type: ApplicationFiled: July 4, 2003Publication date: February 16, 2006Inventors: Hans Soderlund, Reetta Satokari, Kari Kataja, Kristiina Takkinen
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Publication number: 20060018233Abstract: A method and miniaturizable device is described to read/write information to an optical storage medium (11). A device comprises one or more light sources (12) bounded up with an access unit (10) which is arranged to be controllable to a position, in which light beams (21, 22) are transmitted transversal towards an optical storage medium, and reflected light beams (33) are analysed by a detector element (18, 26) which further informs the access unit whether to move or stand still to keep light beams in focus and on track. A device according to the invention is possible to implement in a small size and low weight due to reduced component count and thin access unit geometries. A communication device (80) according to the invention may be implemented to fulfil a crucial need for ultraminiature range of communication devices.Type: ApplicationFiled: November 27, 2002Publication date: January 26, 2006Inventors: Jakke Makela, Janne Aikio, Sanna Aikio, Kari Kataja, Teemu Alajoki
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Publication number: 20040053300Abstract: The invention is related to a method and test kits for quantitative determination of polynucleotide amounts present in a sample. The test kit comprises organized pools with polynucleotide probes having distinct sizes and optionally provided with tracer tags or primer tags. The probes are allowed to hybridize with affinity tagged analyte polynucleotides from the sample. The result is hybrids, which can be recovered on a separation aiding tool provided with the pair of the affinity tag. After the quantitative release of the probes, the probes are either directly recorded, or if primer tagged, they are amplified and optionally provided with a tracer tag before recording. The invention provides a sensitive and quantitative determination of the amount polynucleotides present in a cell or tissue sample and allows a quantitative assessment of variations in the amounts of polynucleotides as a response to inherent changes or due to external stimuli.Type: ApplicationFiled: July 10, 2003Publication date: March 18, 2004Inventors: Hans Soderlund, Kari Kataja, Marja Paloheimo, Marja Ilmen, Kristiina Takkinen