Patents by Inventor Karin Breunig

Karin Breunig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OPTIMIZED HOST/VECTOR SYSTEM FOR PRODUCING PROTECTIVE MONO- AND MULTIVALENT SUBUNIT VACCINES ON THE BASIS OF THE YEAST KLUYVEROMYCES LACTIS
    Publication number: 20240102031
    Abstract: Described herein are recombinant Kluyveromyces lactis (K. lactis) yeasts which are capable of the highly efficient expression of one or more foreign proteins and are suitable for use as a vaccine for generating a protective immune response against pathogens. The invention provides in particular K. lactis strains for the targeted cloning of foreign antigen-coding nucleic acids into the yeast genome of the K. lactis strain, which is characterized in that the K. lactis strain has integrated expression cassettes for foreign antigens as an alternative or in addition to the KILAC4 locus on the KIURA3-20 locus (KLLA0E22771g) and/or on the KIMET5-1 locus (KLLA0B03938g). The invention further relates to integrative expression vectors and to methods for producing the K. lactis strains of the invention as well as to the use thereof as vaccines.
    Type: Application
    Filed: October 5, 2023
    Publication date: March 28, 2024
    Applicant: VEROVACCINES GMBH
    Inventors: Hans Caspar HÜHRLIMANN, Martina BEHRENS, Mandy GEBAUER, Karin BREUNIG, Sven-Erik BEHRENS
  • Optimized host/vector system for producing protective mono- and multivalent subunit vaccines on the basis of the yeast
    Patent number: 11905517
    Abstract: The invention relates to recombinant Kluyveromyces lactis (K. lactis) yeasts which are capable of the highly efficient expression of one or more foreign proteins and are suitable for use as a vaccine for generating a protective immune response against pathogens. The invention provides in particular K. lactis strains for the targeted cloning of foreign antigen-coding nucleic acids into the yeast genome of the K. lactis strain, which is characterized in that the K. lactis strain has integrated expression cassettes for foreign antigens as an alternative or in addition to the KILAC4 locus on the KIURA3-20 locus (KLLA0E22771g) and/or on the KIMET5-1 locus (KLLA0B03938g). The invention further relates to integrative expression vectors and to methods for producing the K. lactis strains of the invention as well as to the use thereof as vaccines.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: February 20, 2024
    Assignee: VEROVACCINES GMBH
    Inventors: Hans Caspar Hührlimann, Martina Behrens, Mandy Gebauer, Karin Breunig, Sven-Erik Behrens
  • OPTIMIZED HOST/VECTOR SYSTEM FOR PRODUCING PROTECTIVE MONO- AND MULTIVALENT SUBUNIT VACCINES ON THE BASIS OF THE YEAST KLUYVEROMYCES LACTIS
    Publication number: 20210230612
    Abstract: The invention relates to recombinant Kluyveromyces lactis (K. lactis) yeasts which are capable of the highly efficient expression of one or more foreign proteins and are suitable for use as a vaccine for generating a protective immune response against pathogens. The invention provides in particular K. lactis strains for the targeted cloning of foreign antigen-coding nucleic acids into the yeast genome of the K. lactis strain, which is characterized in that the K. lactis strain has integrated expression cassettes for foreign antigens as an alternative or in addition to the KILAC4 locus on the KIURA3-20 locus (KLLA0E22771g) and/or on the KIMET5-1 locus (KLLA0B03938g). The invention further relates to integrative expression vectors and to methods for producing the K. lactis strains of the invention as well as to the use thereof as vaccines.
    Type: Application
    Filed: December 19, 2018
    Publication date: July 29, 2021
    Applicant: VEROVACCINES GMBH
    Inventors: Hans Caspar HÜHRLIMANN, Martina BEHRENS, Mandy GEBAUER, Karin BREUNIG, Sven-Erik BEHRENS
  • Vaccination by means of recombinant yeast by producing a protective humoral immune response against defined antigens
    Patent number: 11065312
    Abstract: The invention relates to recombinant yeasts of the Kluyveromyces lactis species for the production of a humoral immune response against defined antigens, to the production of said yeasts, and to the use thereof for protective vaccination against pathogens and malignant cells containing said antigens.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: July 20, 2021
    Assignee: VEROVACCiNES Gmbh
    Inventors: Karin Breunig, Sven-Erik Behrens
  • Method for the oral/mucosal vaccination by means of recombinant yeasts
    Patent number: 9885052
    Abstract: Recombinant yeast cells are produced which are used for vaccination, among other uses for the oral vaccination by feeding.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: February 6, 2018
    Assignee: Martin-Luther-Universitaet Halle-Wittenberg
    Inventors: Karin Breunig, Sven-Erik Behrens
  • VACCINATION BY MEANS OF RECOMBINANT YEAST BY PRODUCING A PROTECTIVE HUMORAL IMMUNE RESPONSE AGAINST DEFINED ANTIGENS
    Publication number: 20150190486
    Abstract: The invention relates to recombinant yeasts of the Kluyveromyces lactis species for the production of a humoral immune response against defined antigens, to the production of said yeasts, and to the use thereof for protective vaccination against pathogens and malignant cells containing said antigens.
    Type: Application
    Filed: December 12, 2012
    Publication date: July 9, 2015
    Inventors: Karin Breunig, Sven-Erik Behrens
  • METHOD FOR THE ORAL/MUCOSAL VACCINATION BY MEANS OF RECOMBINANT YEASTS
    Publication number: 20110293659
    Abstract: Recombinant yeast cells are produced which are used for vaccination, among other uses for the oral vaccination by feeding.
    Type: Application
    Filed: November 13, 2009
    Publication date: December 1, 2011
    Inventors: Karin Breunig, Seven-Erik Behrens