Patents by Inventor Karin Jooss

Karin Jooss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HOMOLOGOUS ADENOVIRAL VACCINATION
    Publication number: 20240093235
    Abstract: Disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a homologous prime/boost vaccination strategy, such as adenoviral vectors for use in a homologous prime/boost vaccination strategy.
    Type: Application
    Filed: December 3, 2021
    Publication date: March 21, 2024
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin, Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Amy Rachel Rappaport, Christine Denise Palmer
  • VIRAL DELIVERY OF NEOANTIGENS
    Publication number: 20240067985
    Abstract: Disclosed herein are chimpanzee adenoviral vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: January 10, 2023
    Publication date: February 29, 2024
    Inventors: Wade Blair, Brendan Bulik-Sullivan, Jennifer Busby, Adnan Derti, Leonid Gitlin, Karin Jooss, Ciaran Daniel Scallan, Roman Yelensky, Gijsbert Grotenbreg
  • ENGINEERED MULTI-SPECIFIC ANTIBODIES AND RELATED METHODS OF USE AND MANUFACTURE
    Publication number: 20240059797
    Abstract: Provided herein are multispecific antigen binding proteins (ABPs). Also provided herein are multispecific ABPs that are engineered to form diabodies or stay in extended (dual scFv) conformation and methods for purifying ABPs based on avidity.
    Type: Application
    Filed: July 29, 2021
    Publication date: February 22, 2024
    Inventors: Godfrey Jonah Anderson Rainey, Karin Jooss, Shan Liu Hwang, Gayatri Prakash, Isaac J. Rondon
  • INFECTIOUS DISEASE ANTIGENS AND VACCINES
    Publication number: 20240050550
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
    Type: Application
    Filed: October 3, 2022
    Publication date: February 15, 2024
    Inventors: Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer
  • ALPHAVIRUS NEOANTIGEN VECTORS
    Publication number: 20240024445
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: October 11, 2022
    Publication date: January 25, 2024
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • MODIFIED ADENOVIRUSES
    Publication number: 20230407332
    Abstract: Compositions include modified adenoviruses. Nucleotides, cells, and methods associated with the compositions, including their use as vaccines. Viral vectors using a TET promoter system and methods of producing viruses having the same.
    Type: Application
    Filed: January 4, 2023
    Publication date: December 21, 2023
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
  • ANTIGEN-BINDING PROTEINS TARGETING SHARED ANTIGENS
    Publication number: 20230382997
    Abstract: Provided herein are HLA-PEPTIDE targets and antigen binding proteins that bind HLA-PEPTIDE targets. Also disclosed are methods for identifying the HLA-PEPTIDE targets as well as identifying one or more antigen binding proteins that bind a give n HLA-PEPTIDE target.
    Type: Application
    Filed: December 13, 2022
    Publication date: November 30, 2023
    Inventors: Karin Jooss, Wade Blair, Brendan Bulik-Sullivan, Jennifer Busby, Michele Anne Busby, Joshua Michael Francis, Gijsbert Marnix Grotenbreg, Mojca Skoberne, Roman Yelensky
  • SARS-COV-2 VACCINES
    Publication number: 20230330215
    Abstract: Disclosed herein are vaccine compositions that include SARS-CoV-2 MHC epitope-encoding cassettes and/or full-length SARS-CoV-2 proteins. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: November 18, 2022
    Publication date: October 19, 2023
    Inventors: Roman Yelensky, Minh Duc Cao, Mike Zhong, Justin Helbert, Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin, Amy Rachel Rappaport
  • ANTIGEN-ENCODING CASSETTES
    Publication number: 20230310563
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple repeats of distinct epitope-encoding sequences or having antigen-encoding nucleic acid sequences having less than 700 nucleotides and encoding multiple distinct epitope-encoding sequences. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: October 20, 2022
    Publication date: October 5, 2023
    Inventors: Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • Multiepitope vaccine cassettes
    Patent number: 11771747
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Grant
    Filed: April 22, 2022
    Date of Patent: October 3, 2023
    Assignee: Gritstone Bio, Inc.
    Inventors: Karin Jooss, Roman Yelensky, James Xin Sun, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Monica Lane
  • CAPPING COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20230303614
    Abstract: The present disclosure includes, among other things, non-natural nucleotides useful as 5? caps for RNA nucleotides. The present disclosure also includes, among other things, compositions and methods using delivery and vaccine RNA nucleotide compositions that include non-natural nucleotides as 5? caps.
    Type: Application
    Filed: October 20, 2022
    Publication date: September 28, 2023
    Inventors: Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Sue-Jean Hong, Arvin Akoopie
  • ANTIGEN-BINDING PROTEINS AND RELATED METHODS OF USE
    Publication number: 20230295305
    Abstract: Provided herein are antigen binding proteins (ABPs) that bind HLA-PEPTIDE targets. Also disclosed are methods for identifying the HLA-PEPTIDE targets and methods of treating cancers and other diseases using the disclosed ABPs.
    Type: Application
    Filed: April 14, 2023
    Publication date: September 21, 2023
    Inventors: Godfrey Jonah Anderson Rainey, Karin Jooss, Roman Yelensky, Wade Blair, Heungnam Kim, Christine Janson, Anne Van Abbema, Isaac J. Rondon
  • ANTIGEN-BINDING PROTEINS TARGETING KKLC-1 SHARED ANTIGEN
    Publication number: 20230287128
    Abstract: Provided herein are antigen binding proteins that selectively bind a particular KKLC-1 shared antigen, as well as related methods, kits, and compositions.
    Type: Application
    Filed: August 17, 2022
    Publication date: September 14, 2023
    Inventors: Godfrey Jonah Anderson Rainey, Karin Jooss, Manankumar Anilkumar Shah
  • HIV ANTIGENS AND MHC COMPLEXES
    Publication number: 20230128001
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines against infectious diseases such as HIV.
    Type: Application
    Filed: August 3, 2022
    Publication date: April 27, 2023
    Inventors: Roman Yelensky, James Xin Sun, Joshua Klein, Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
  • Modified adenoviruses
    Patent number: 11591619
    Abstract: Compositions include modified adenoviruses. Nucleotides, cells, and methods associated with the compositions, including their use as vaccines. Viral vectors using a TET promoter system and methods of producing viruses having the same.
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: February 28, 2023
    Assignee: GRITSTONE BIO, INC.
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
  • DURABLE VACCINATION
    Publication number: 20230047979
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
    Type: Application
    Filed: June 10, 2022
    Publication date: February 16, 2023
    Inventors: Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • ANTIGEN-BINDING PROTEINS TARGETING SHARED NEOANTIGENS
    Publication number: 20230041030
    Abstract: Provided herein are target HLA-PEPTIDE antigens, e.g., HLA-PEPTIDE neoantigens and shared tumor HLA-PEPTIDE antigens, and antigen binding proteins (ABPs) that bind the target HLA-PEPTIDE antigens. Also disclosed are methods for identifying target HLA-PEPTIDE antigens as well as identifying one or more antigen binding proteins that bind a given HLA-PEPTIDE target antigen.
    Type: Application
    Filed: May 13, 2022
    Publication date: February 9, 2023
    Inventors: Karin Jooss, Aleksandra Katarzyna Nowicka, Abubakar Jalloh, Roman Yelensky, James Xin Sun, Jennifer Busby, Matthew Joseph Davis
  • SHARED NEOANTIGEN VACCINES
    Publication number: 20230020089
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccincation strategy.
    Type: Application
    Filed: May 4, 2022
    Publication date: January 19, 2023
    Inventors: Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Jennifer Busby, Brendan Bulik-Sullivan, Mojca Skoberne, Wade Blair
  • Alphavirus antigen vectors
    Patent number: 11510973
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: November 29, 2022
    Assignee: GRITSTONE BIO, INC.
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • Alphavirus neoantigen vectors
    Patent number: 11504421
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: November 22, 2022
    Assignee: GRITSTONE BIO, INC.
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin