Patents by Inventor Karina Jouravleva

Karina Jouravleva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heated stage assembly for high temperature fluorescence microscopy
    Patent number: 11841492
    Abstract: The invention is directed to a heated stage assembly that can achieve high temperatures (i.e., 40 degrees Celsius and higher and more specifically, 55 degrees Celsius and higher) for use in microscopy including fluorescence microscopy. The microscope stage heater assembly includes a mounting adapter element, a sample holder element mounted within the mounting adapter element, one or more heating elements attached to the sample holder element, and an optical window holder element disposed on a surface of the sample holder element that encloses an optical window element. The optical window element may be in contact with a microscope sample such that the optical window element is heated by the sample holder element to uniformly distribute heat to the specimen.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: December 12, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: David Grunwald, Maximiliaan Huisman, Karina Jouravleva, Carlas Smith, Phillip D. Zamore
  • COMPOSITIONS AND METHODS FOR RNA INTERFERENCE
    Publication number: 20220298507
    Abstract: The disclosure provides inhibitory RNA polynucleotides that have partial complementarity to a target gene. The inhibitory RNA polynucleotides have at least one mismatched nucleotide and can be designed to increase or decrease the cleavage rate when loaded onto the RNA-induced silencing complex (RISC).
    Type: Application
    Filed: June 10, 2020
    Publication date: September 22, 2022
    Inventors: William J. Greenleaf, Phillip D. Zamore, Winston R. Becker, Benjamin Ober-Reynolds, Karina Jouravleva, Samson M. Jolly
  • Heated Stage Assembly For High Temperature Fluorescence Microscopy
    Publication number: 20220050282
    Abstract: The invention is directed to a heated stage assembly that can achieve high temperatures (i.e., 40 degrees Celsius and higher and more specifically, 55 degrees Celsius and higher) for use in microscopy including fluorescence microscopy. The microscope stage heater assembly includes a mounting adapter element, a sample holder element mounted within the mounting adapter element, one or more heating elements attached to the sample holder element, and an optical window holder element disposed on a surface of the sample holder element that encloses an optical window element. The optical window element may be in contact with a microscope sample such that the optical window element is heated by the sample holder element to uniformly distribute heat to the specimen.
    Type: Application
    Filed: September 13, 2019
    Publication date: February 17, 2022
    Inventors: David Grunwald, Maximiliaan Huisman, Karina Jouravleva, Carlas Smith, Phillip D. Zamore