Patents by Inventor Karina Yusim

Karina Yusim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HEPATITIS B VIRUS VACCINES
    Publication number: 20220288195
    Abstract: The present disclosure relates to isolated polynucleotides and polypeptides, and related hepatitis B virus (HBV)vaccines. The present disclosure also relates to viral vectors for expressing such polypeptides, and which may be used in HBV vaccines, as well as methods of protecting a subject from HBV infection and methods of treating HBV in a subject comprising administering the polypeptides, vectors, or vaccines described herein. Methods of designing and producing an HBV vaccine comprising designing vaccine antigens to cover the diversity within a geographic area using an antigen amino acid sequence that efficiently covers the epitopes in the HBV genotypes present in the geographic area are also provided herein.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 15, 2022
    Inventors: Eric BRUENING, Janet DOUGLAS, Emily MARSHALL, Karina YUSIM, Bette KORBER, James THEILER
  • Signature-based human immunodeficiency virus (HIV) envelope (Env) trimer vaccines and methods of using the same
    Patent number: 11230572
    Abstract: The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: January 25, 2022
    Assignees: Beth Israel Deaconess Medical Center, Inc., Triad National Security, LLC
    Inventors: Dan H. Barouch, Christine Bricault, Bette T. Korber, Karina Yusim
  • SIGNATURE-BASED HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPE (ENV) TRIMER VACCINES AND METHODS OF USING THE SAME
    Publication number: 20200055901
    Abstract: The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).
    Type: Application
    Filed: October 17, 2017
    Publication date: February 20, 2020
    Inventors: Dan H. BAROUCH, Christine BRICAULT, Bette T. KORBER, Karina YUSIM
  • Nucleic acids encoding mosaic HIV-1 gag proteins
    Patent number: 9492532
    Abstract: The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 15, 2016
    Assignees: DUKE UNIVERSITY, U. OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION, BETH ISRAEL DEACONESS MEDICAL CENTER, LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • POLYVALENT VACCINE
    Publication number: 20150359875
    Abstract: The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.
    Type: Application
    Filed: April 17, 2015
    Publication date: December 17, 2015
    Inventors: Bette T. KORBER, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • Human immunodeficiency virus type 1 clade M mosaic gag polypeptides
    Patent number: 9011875
    Abstract: The present invention relates to mosaic HIV-1 group M Gag sequences and to a composition comprising same.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: April 21, 2015
    Assignees: Los Alamos National Security, LLC, Beth Israel Deaconess Medical Center, Duke University, The University of Alabama at Birmingham Research Foundation
    Inventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • Mosaic protein and nucleic acid vaccines against hepatitis C virus
    Patent number: 8460672
    Abstract: The invention relates to immunogenic compositions useful as HCV vaccines. Provided are HCV mosaic polypeptide and nucleic acid compositions which provide higher levels of T-cell epitope coverage while minimizing the occurrence of unnatural and rare epitopes compared to natural HCV polypeptides and consensus HCV sequences.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: June 11, 2013
    Assignee: Los Alamos National Security, LLC
    Inventors: Karina Yusim, Bette T. M. Korber, Carla L. Kuiken, William M. Fischer
  • POLYVALENT VACCINE
    Publication number: 20120231028
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: February 17, 2012
    Publication date: September 13, 2012
    Applicants: Los Alamos National Security, LLC, The University of Alabama at Birmingham Research Foundation, Duke University, Beth Israel Deaconess Medical Center
    Inventors: Bette T. KORBER, Simon PERKINS, Tanmoy BHATTACHARYA, William M. FISCHER, James THEILER, Norman LETVIN, Barton F. HAYNES, Beatrice H. HAHN, Karina YUSIM, Carla KUIKEN
  • Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins
    Patent number: 8119140
    Abstract: The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: February 21, 2012
    Assignees: Los Alamos Security, LLC, Beth Israel Deaconess Medical Center, Duke University, The University of Alabama at Birmingham Research Foundation
    Inventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • POLYVALENT VACCINE
    Publication number: 20110150915
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: December 3, 2010
    Publication date: June 23, 2011
    Applicants: Los Alamos National Security, LLC, Beth Israel Deaconess Medical Center, Duke University, The University of Alabama at Birmingham Research Foundation
    Inventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken
  • Polyvalent Vaccine
    Publication number: 20090324631
    Abstract: The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
    Type: Application
    Filed: August 23, 2006
    Publication date: December 31, 2009
    Applicant: LOS ALAMOS NATIONAL SECURITY, LLC LOS ALAMOS NATIONAL LABORATORY, LC/IP
    Inventors: Bette T. Korber, Simon Perkins, Tanmoy Bhattacharya, William M. Fischer, James Theiler, Norman Letvin, Barton F. Haynes, Beatrice H. Hahn, Karina Yusim, Carla Kuiken