Abstract: The present invention relates to compounds of formula wherein the residues have various meanings and their use as pharmaceuticals.

Abstract: The present invention relates to compounds of formula wherein the residues have various meanings and their use as pharmaceuticals.

Abstract: Tetrahydro-pyrrolizinone compounds which mediate the activity of LFA-1 with its ligands involved in cell adhesion, migration and activation.

Abstract: 3a,4,5,6-Tetrahydro-pyrrolol,2-b]-isothiazoles wherein the sulphur is in the form of a dioxide and their use for the treatment or prevention of disorders mediated by interactions of LFA-1 with its ligands involved in cell adhesion, migration and activation.

Abstract: The invention concerns the compounds of formula I ##STR1## wherein the substituents have various significances. They are prepared by several processes including epimerizing replacement, treatment with cyanogen bromide or thiophosgene, treatment with an acid having a non-nucleophilic anion, treatment with dimethylsulfoxide and acetic anhydride, acylation, treatment with an oxalyl derivative and ammonia, methylation, oxidation, deprotection and protection. They possess interesting pharmacological activity as antiinflammatory, immunosuppressant, antiproliferative and chemotherapeutic drug resistance reversing agents.

Abstract: Play-free longitudinal guiding means having rails than run inside each other, namely a lower rail and an upper rail that can be displaced in a sliding manner with respect to the lower rail, for securing seats in vehicles such as private cars. The play-free longitudinal guiding means is such that the lower rail features along its length wall parts that have the shape of alignment grooves, and the upper rail features wall parts which run parallel to the wall parts of the lower rail and are shaped into an alignment groove, and the alignment grooves of the upper and lower rails face each other and form a sliding alignment channel. In the sliding channel there are sliding elements which in the free-standing condition exhibit a larger cross-section than in the installed condition, and the sliding elements guide the lower and upper rails without any play.

Abstract: The invention concerns the compounds of formulae ##STR1## wherein the substituents have various significances. They can be prepared by various methods, e.g. acylation, reduction, alkylation, etc. They are indicated for use as pharmaceuticals, in particular as immunosuppressant, antiproliferative and antiinflammatory agents.

Abstract: The invention concerns the compounds of formula I ##STR1## wherein the substituents have various significances. They are prepared by several processes including epimerizing replacement, treatment with cyanogen bromide or thiophosgene, treatment with an acid having a non-nucleophilic anion, treatment with dimethylsulfoxide and acetic anhydride, acylation, treatment with an oxalyl derivative and ammonia, methylation, oxidation, deprotection and protection.They possess interesting pharmacological activity as antiinflammatory, immunosuppressant, antiproliferative and chemotherapeutic drug resistance reversing agents.

Abstract: A process for the preparation of compounds of formula I ##STR1## in which X is the radical OH or Cl, by the catalytic hydrogenation of 3,5-dimethyl-4-methoxy-2-cyanopyridine, subsequent reaction of the resulting 3,5-dimethyl-4-methoxy-2-aminomethylpyridine to give 3,5-dimethyl-4-methoxy-2-hydroxymethylpyridine and, if desired, chlorination to give 3,5-dimethyl-4-methoxy-2-chloromethylpyridine, and the novel intermediate 3,5-dimethyl-4-methoxy-2-aminomethylpyridine.

Abstract: New 4-Pyridone derivatives of General Formula are claimed ##STR1## in which R.sub.1 is methylamino,4-fluorophenyl, 2,4-difluorophenyl, R.sub.2 is hydrogen or a sulfur atom that is joined to the ring nitrogen by an ethylene bride, X is a hydrogen or a physiologically removable ester group and Y is a base of the general formula ##STR2## In formula IIa and IIb, R.sub.3 is hydrogen, lower alkyl, benzyl, formyl, acetonyl or a moiety of the formula ##STR3## Also claimed are the addition salts of compounds of formula I with pharmaceutically acceptable inorganic or organic acids or base and/or their hydrates. Also claimed are the methods of manufacture of compounds of formula I and their use as antibacterial agents.

Abstract: Process for the preparation of substituted 3-amino-2-(benzoyl)-acrylic acid esters of the formula I ##STR1## in which R.sub.1 denotes an alkyl radical with 1 to 4 C atoms, X.sub.1 denotes halogen, in particular fluorine or chlorine, X.sub.2, X.sub.3, X.sub.4 and X.sub.5 denote hydrogen, halogen, in particular fluorine or chlorine, an alkyl radical having 1-4 C atoms or an alkoxy radical having 1-4 C atoms in the alkyl chain, by selectively reducing a substituted 2-cyano-3-hydroxy-3(phenyl)acrylic acid ester of the formula II ##STR2## in which R.sub.1, X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5 have the meaning given above, and a process for the preparation of intermediate products for antibacterially active compounds from these compounds.

Abstract: A multiple holder for substrates to be treated, particularly finish-ground spectacle lenses to be cleaned and then coated, comprises four arms 1a to 1d forming a rectangular cross. On their sides facing the four quadrants, the arms are provided with grooves for receiving the substrates 11 to be treated which substrates are forced by springs 4a to 4d to engage the grooves. The holder is used primarily for the secure holding and transportation of substrates during a sequence of treating operations.