Patents by Inventor Karl De Vore
Karl De Vore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11385245Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data.Type: GrantFiled: May 21, 2020Date of Patent: July 12, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Patent number: 11090227Abstract: Methods and devices for transferring materials between containers are discussed. One such connector includes: a base; a first elongate structure having first and second ends, the first elongate structure extending from a first side of the base at the first end to the second end distal the base, the second end forming a first opening sized and configured to receive a first container; a duct extending through the base and having a first tip skirted on one or more sides by the first elongate structure; a first guard positioned within the first elongate structure, wherein the first guard comprises a first surface, and the first surface is located further away from the base than the first tip. When the first container is moved into the first opening, the first surface moves toward the base, and the first tip enters the first container, creating a fluid path for the first container.Type: GrantFiled: June 1, 2018Date of Patent: August 17, 2021Assignee: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Karl De Vore, John Sass
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Publication number: 20200284809Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data.Type: ApplicationFiled: May 21, 2020Publication date: September 10, 2020Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Patent number: 10697981Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data.Type: GrantFiled: December 20, 2017Date of Patent: June 30, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Patent number: 10539581Abstract: Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.Type: GrantFiled: October 21, 2016Date of Patent: January 21, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Publication number: 20190365605Abstract: Methods and devices for transferring materials between containers are discussed. One such connector includes: a base; a first elongate structure having first and second ends, the first elongate structure extending from a first side of the base at the first end to the second end distal the base, the second end forming a first opening sized and configured to receive a first container; a duct extending through the base and having a first tip skirted on one or more sides by the first elongate structure; a first guard positioned within the first elongate structure, wherein the first guard comprises a first surface, and the first surface is located further away from the base than the first tip. When the first container is moved into the first opening, the first surface moves toward the base, and the first tip enters the first container, creating a fluid path for the first container.Type: ApplicationFiled: June 1, 2018Publication date: December 5, 2019Applicant: BIO-RAD LABORATORIES, INC.Inventors: Alireza Ebrahim, Karl De Vore, John Sass
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Patent number: 10495653Abstract: Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.Type: GrantFiled: January 20, 2017Date of Patent: December 3, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Publication number: 20180203023Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data.Type: ApplicationFiled: December 20, 2017Publication date: July 19, 2018Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Patent number: 9909959Abstract: Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay.Type: GrantFiled: October 18, 2016Date of Patent: March 6, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Christopher Spates, Karl De Vore
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Patent number: 9885728Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data.Type: GrantFiled: August 20, 2015Date of Patent: February 6, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Publication number: 20170131302Abstract: Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.Type: ApplicationFiled: January 20, 2017Publication date: May 11, 2017Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Publication number: 20170122970Abstract: Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.Type: ApplicationFiled: October 21, 2016Publication date: May 4, 2017Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Patent number: 9599543Abstract: Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay.Type: GrantFiled: November 11, 2015Date of Patent: March 21, 2017Assignee: BIO-RAD LABORATORIES, INC.Inventors: Alireza Ebrahim, Christopher Spates, Karl De Vore
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Publication number: 20170038400Abstract: Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay.Type: ApplicationFiled: October 18, 2016Publication date: February 9, 2017Inventors: Alireza EBRAHIM, Christopher SPATES, Karl DE VORE
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Patent number: 9506939Abstract: Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.Type: GrantFiled: May 6, 2014Date of Patent: November 29, 2016Assignee: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Patent number: 9354144Abstract: Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay.Type: GrantFiled: August 24, 2012Date of Patent: May 31, 2016Assignee: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Christopher Spates, Karl De Vore
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Publication number: 20160061694Abstract: Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay.Type: ApplicationFiled: November 11, 2015Publication date: March 3, 2016Inventors: Alireza Ebrahim, Christopher Spates, Karl De Vore
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Publication number: 20160054339Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data.Type: ApplicationFiled: August 20, 2015Publication date: February 25, 2016Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Publication number: 20140329263Abstract: Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.Type: ApplicationFiled: May 6, 2014Publication date: November 6, 2014Applicant: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates
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Publication number: 20140134597Abstract: Intact erythrocytes with selected and often elevated levels of hemoglobin A1c (HbA1c) for use as quality controls for HbA1c assays and assay instruments are prepared by hypotonic dialysis of erythrocytes from a healthy mammal to permeabilize the erythrocyte membranes, infusion of the permeabilized erythrocytes with hemoglobin A1c, and de-permeabilization of the infused erythrocytes. Quality controls of essentially any level of HbA1c can be prepared in this manner and once prepared will be useful for monitoring the entire assay procedure, including the lysis of the erythrocytes in a typical sample.Type: ApplicationFiled: October 24, 2013Publication date: May 15, 2014Applicant: Bio-Rad Laboratories, Inc.Inventors: Alireza Ebrahim, Karl De Vore, Christopher Spates