Patents by Inventor Karl J. Guegler

Karl J. Guegler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR DIAGNOSING DISEASES ASSOCIATED WITH HUMAN SIGNAL PEPTIDE-CONTAINING MOLECULES
    Publication number: 20180136213
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Application
    Filed: January 2, 2018
    Publication date: May 17, 2018
    Applicant: Incyte Corporation
    Inventors: Preeti G. Lal, Y. Tom Tang, Gina A. Gorgone Simone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice K. Au-Young, Henry Yue, Chandra S. Arvizu, Roopa M. Reddy, Jennifer L. Jackson, Olga Bandman
  • Methods for detecting expression levels of human signal peptide-containing proteins (HSPP)
    Patent number: 9885717
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: February 6, 2018
    Assignee: INCYTE CORPORATION
    Inventors: Preeti G. Lal, Y. Tom Tang, Gina A. Gorgone Simone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice K. Au-Young, Henry Yue, Chandra S. Arvizu, Roopa M. Reddy, Jennifer L. Jackson, Olga Bandman
  • Methods for treating colon cancer and inflammation associated with overexpression of human signal peptide-containing proteins
    Patent number: 9512234
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Grant
    Filed: June 27, 2015
    Date of Patent: December 6, 2016
    Assignee: INCYTE CORPORATION
    Inventors: Preeti G. Lal, Y. Tom Tang, Gina A. Gorgone Simone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice K. Au-Young, Henry Yue, Chandra S. Arvizu, Roopa M. Reddy, Jennifer L. Jackson, Olga Bandman
  • METHODS FOR DIAGNOSING DISEASES ASSOCIATED WITH HUMAN SIGNAL PEPTIDE-CONTAINING MOLECULES
    Publication number: 20160349260
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Application
    Filed: August 11, 2016
    Publication date: December 1, 2016
    Applicant: Incyte Corporation
    Inventors: Preeti G. LAL, Y. Tom Tang, Gina A. Gorgone Simone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice K. Au-Young, Henry Yue, Chandra S. Arvizu, Roopa M. Reddy, Jennifer L. Jackson, Olga Bandman
  • ANTIBODIES TO HUMAN SIGNAL PEPTIDE-CONTAINING PROTEINS
    Publication number: 20160130332
    Abstract: The invention provides a human signal peptide-containing proteins (SIGP) and polynucleotides which identify and encode SIGP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of SIGP.
    Type: Application
    Filed: January 19, 2016
    Publication date: May 12, 2016
    Inventors: Preeti G. Lal, Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Dr. Mariah R. Baughn, Susan K. Sather, Purvi Shah
  • METHODS FOR TREATING DISORDERS ASSOCIATED WITH HUMAN SIGNAL PEPTIDE-CONTAINING MOLECULES
    Publication number: 20150291701
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Application
    Filed: June 27, 2015
    Publication date: October 15, 2015
    Applicant: Incyte Corporation
    Inventors: Preeti G. LAL, Y. Tom Tang, Gina A. Gorgone Simone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice K. Au-Young, Henry Yue, Chandra S. Arvizu, Roopa M. Reddy, Jennifer L. Jackson, Olga Bandman
  • Antibodies which bind to signal peptide-containing molecules
    Patent number: 9102745
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: August 11, 2015
    Assignee: INCYTE CORPORATION
    Inventors: Preeti G. Lal, Y. Tom Tang, Gina A. Gorgone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice K. Au-Young, Henry Yue, Chandra S. Arvizu, Roopa M. Reddy, Jennifer L. Jackson, Olga Bandman
  • ANTIBODIES TO HUMAN TRANSMEMBRANE PROTEINS
    Publication number: 20150017173
    Abstract: The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.
    Type: Application
    Filed: August 28, 2014
    Publication date: January 15, 2015
    Applicant: Incyte Corporation
    Inventors: Y. Tom Tang, Preeti G. Lal, Jennifer L. Jackson, Henry Yue, Karl J. Guegler, Neil C. Corley, Olga Bandman, Chandra S. Arvizu, Gina A. Gorgone Simone, Matthew R. Kaser, Mariah R. Baughn, Janice K. Au-Young
  • Method to Quantify siRNAs, miRNAs and Polymorphic miRNAs
    Publication number: 20140377748
    Abstract: The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3? end of a target polynucleotide, using a ligase that can ligate the 3? end of RNA to the 5? end of DNA using a DNA template, such as T4 DNA ligase. Following digestion to form an elongated target polynucleotide with a liberated end, a reverse transcription reaction can be performed, followed by a PCR. In some embodiments, the methods of the present teachings can discriminate between polymorphic polynucleotides that vary by as little as one nucleotide.
    Type: Application
    Filed: March 28, 2014
    Publication date: December 25, 2014
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Ruoying TAN, Caifu Chen, Karl J. Guegler
  • POLYNUCLEOTIDES ENCODING SIGNAL PEPTIDE-CONTAINING MOLECULES
    Publication number: 20140242086
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 28, 2014
    Applicant: Incyte Corporation
    Inventors: Preeti G. Lal, Y. Tom Tang, Gina A. Gorgone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice K. Au-Young, Henry Yue, Chandra S. Arvizu, Roopa M. Reddy, Jennifer L. Jackson, Olga Bandman
  • ANTIBODIES TO HUMAN SIGNAL PEPTIDE-CONTAINING PROTEINS
    Publication number: 20140227278
    Abstract: The invention provides a human signal peptide-containing proteins (SIGP) and polynucleotides which identify and encode SIGP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of SIGP.
    Type: Application
    Filed: February 11, 2014
    Publication date: August 14, 2014
    Applicant: Incyte Corporation
    Inventors: Preeti G. LAL, Jennifer L. Jackson, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Susan K. Sather, Purvi Shah
  • Compositions comprising signal peptide-containing proteins
    Patent number: 8716445
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: May 6, 2014
    Assignee: Incyte Corporation
    Inventors: Preeti G. Lal, Y. Tom Tang, Gina A. Gorgone Simone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice K. Au-Young, Henry Yue, Chandra S. Arvizu, Roopa M. Reddy, Jennifer L. Hillman, Olga Bandman
  • Method to quantify siRNAs, miRNAs and polymorphic miRNAs
    Patent number: 8710208
    Abstract: The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3? end of a target polynucleotide, using a ligase that can ligate the 3? end of RNA to the 5? end of DNA using a DNA template, such as T4 DNA ligase. Following digestion to form an elongated target polynucleotide with a liberated end, a reverse transcription reaction can be performed, followed by a PCR. In some embodiments, the methods of the present teachings can discriminate between polymorphic polynucleotides that vary by as little as one nucleotide.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: April 29, 2014
    Assignee: Applied Biosystems, LLC
    Inventors: Ruoying Tan, Caifu Chen, Karl J. Guegler
  • POLYNUCLEOTIDES ENCODING SIGNAL PEPTIDE-CONTAINING MOLECULES
    Publication number: 20130244927
    Abstract: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
    Type: Application
    Filed: February 15, 2012
    Publication date: September 19, 2013
    Inventors: Preeti Lal, Y. Tom Tang, Gina A. Gorgone, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Ingrid E. Akerblom, Janice Au-Young, Henry Yue, Chandra Patterson, Roopa Reddy, Jennifer L. Hillman, Olga Bandman
  • Methods, compositions, and kits for detecting protein aggregates
    Patent number: 8535878
    Abstract: The present teachings provide methods, compositions, and kits for detecting the presence of protein aggregates. In some embodiments, the protein aggregate is treated with a labeled precursor, and the labeled precursor is incorporated into the protein aggregate to form a labeled protein aggregate. The labeled protein aggregate is then measured, thus detecting the presence of the protein aggregate. In some embodiments, the labeled protein aggregate is detected by interaction of labeled precursors, for example by a proximity ligation assay.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: September 17, 2013
    Assignee: Applied Biosystems, LLC
    Inventors: David W. Ruff, Mark E. Shannon, Kenneth J. Livak, Karl J. Guegler, Kevin M. Hennessy
  • Polynucleotides Encoding Human Signal Peptide-Containing Proteins
    Publication number: 20130190250
    Abstract: The invention provides a human signal peptide-containing proteins (SIGP) and polynucleotides which identify and encode SIGP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of SIGP.
    Type: Application
    Filed: September 14, 2012
    Publication date: July 25, 2013
    Inventors: Preeti G. Lal, Jennifer L. Jackson, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn, Susan K. Sather, Purvi Shah
  • METHOD TO QUANTIFY SIRNAS, MIRNAS AND POLYMORPHIC MIRNAS
    Publication number: 20120301876
    Abstract: The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3? end of a target polynucleotide, using a ligase that can ligate the 3? end of RNA to the 5? end of DNA using a DNA template, such as T4 DNA ligase. Following digestion to form an elongated target polynucleotide with a liberated end, a reverse transcription reaction can be performed, followed by a PCR. In some embodiments, the methods of the present teachings can discriminate between polymorphic polynucleoitides that vary by as little as one nucleotide.
    Type: Application
    Filed: April 26, 2012
    Publication date: November 29, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: RUOYING TAN, CAIFU CHEN, KARL J. GUEGLER
  • HUMAN TRANSMEMBRANE PROTEINS
    Publication number: 20120270809
    Abstract: The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.
    Type: Application
    Filed: May 22, 2012
    Publication date: October 25, 2012
    Inventors: Y. Tom Tang, Preeti Lal, Jennifer L. Hillman, Henry Yue, Karl J. Guegler, Neil C. Corley, Olga Bandman, Chandra Patterson, Gina A. Gorgone, Matthew R. Kaser, Mariah R. Baughn, Janice Au-Young
  • Human transmembrane proteins
    Patent number: 8206947
    Abstract: The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: June 26, 2012
    Assignee: Incyte Corporation
    Inventors: Y. Tom Tang, Preeti G. Lal, Jennifer L. Jackson, Henry Yue, Karl J. Guegler, Neil C. Corley, Olga Bandman, Chandra S. Arvizu, Gina A. Gorgone Simone, Matthew R. Kaser, Mariah R. Baughn, Janice K. Au-Young
  • Method to quantify siRNAs, miRNAs and polymorphic miRNAs
    Patent number: 8187815
    Abstract: The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3? end of a target polynucleotide, using a ligase that can ligate the 3? end of RNA to the 5? end of DNA using a DNA template, such as T4 DNA ligase. Following digestion to form an elongated target polynucleotide with a liberated end, a reverse transcription reaction can be performed, followed by a PCR. In some embodiments, the methods of the present teachings can discriminate between polymorphic polynucleotides that vary by as little as one nucleotide.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: May 29, 2012
    Assignee: Applied Biosystems, LLC
    Inventors: Ruoying Tan, Caifu Chen, Karl J. Guegler