Patents by Inventor Karl J. Sanford

Karl J. Sanford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8901262
    Abstract: This invention relates to compositions and methods for producing polymers of isoprene derived from renewable resources, such as isoprene produced from cultured cells that use renewable carbon sources. A starting isoprene composition, such as a bioisoprene composition, is distinguished from petroleum based isoprene by its purity profile (such as lower levels of certain C5 hydrocarbons other than isoprene, presence of certain compounds associated with the biological process for production) and the relative content of the carbon isotopes. Polymers obtained by polymerization of such starting isoprene composition according to this invention, such as a polyisoprene homopolymer or a copolymer having repeat units that are derived from isoprene, are distinguishable from isoprene containing polymers from petrochemical resources.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: December 2, 2014
    Assignees: The Goodyear Tire & Rubber Company, Danisco US Inc.
    Inventors: Joseph C. McAuliffe, Sergey Paramonov, Stephan Rodewald, Karl J. Sanford
  • Patent number: 8895288
    Abstract: The invention features methods producing isoprene and a co-product, such as ethanol, 1,3-propanediol, or hydrogen from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides compositions comprising isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen. Additionally, the invention provides methods of co-producing isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen by culturing cells under conditions suitable for co-production of isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: November 25, 2014
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Gopal K. Chotani, Caroline M. Peres, Derek H. Wells, Karl J. Sanford, Joseph C. McAuliffe
  • Publication number: 20140234926
    Abstract: This invention provides for recombinant anaerobic acetogenic bacterial cells having one or more nucleic acids whereby isoprene, mevalonate and/or other industrial bio-products are produced in a substantially oxygen-free culture condition using synthesis gas as energy and/or carbon source.
    Type: Application
    Filed: November 27, 2013
    Publication date: August 21, 2014
    Applicants: E I Du Pont De Nemours And Company, The Goodyear Tire And Rubber Company, Danisco US Inc
    Inventors: ZACHARY Q. BECK, Marguerite A. Cervin, Gopal K. Chotani, Bruce A. Diner, Janine Fan, Caroline M. Peres, Karl J. Sanford, Miles C. Scotcher, Derek H. Wells, Gregory M. Whited
  • Patent number: 8778647
    Abstract: The invention provides improved methods for the production of isoprene from biological materials using a membrane bioreactor to culture isoprene-producing cells.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: July 15, 2014
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Anthony R. Calabria, Gopal K. Chotani, Robin Fong, Alex T. Nielsen, Karl J. Sanford
  • Publication number: 20140155660
    Abstract: The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a non-flammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity.
    Type: Application
    Filed: May 20, 2013
    Publication date: June 5, 2014
    Applicants: The Goodyear Tire & Rubber Company, Danisco US Inc.
    Inventors: Anthony R. Calabria, Marguerite A. Cervin, Gopal K. Chotani, Richard La Duca, Joseph C. McAuliffe, Michael C. Miller, Timothy A. Sabo, Karl J. Sanford, Erin L. Spring, Gregory M. Whited
  • Publication number: 20140128645
    Abstract: The invention provides for methods for the production of isoprene in recombinant marine bacterial cells via the heterologous expression of isoprene synthase enzymes.
    Type: Application
    Filed: December 20, 2012
    Publication date: May 8, 2014
    Applicants: The Goodyear Tire & Rubber Company, DANISCO US INC.
    Inventors: Richard LA DUCA, Karl J. SANFORD, Gregory M. WHITED
  • Publication number: 20140127770
    Abstract: The invention features methods producing isoprene and a co-product, such as ethanol, 1,3-propanediol, or hydrogen from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides compositions comprising isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen. Additionally, the invention provides methods of co-producing isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen by culturing cells under conditions suitable for co-production of isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen.
    Type: Application
    Filed: January 6, 2014
    Publication date: May 8, 2014
    Applicants: The Goodyear Tire & Rubber Company, Danisco US Inc.
    Inventors: Gopal K. CHOTANI, Joseph C. MCAULIFFE, Caroline M. PERES, Karl J. SANFORD, Derek H. WELLS
  • Patent number: 8709785
    Abstract: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: April 29, 2014
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Marguerite A. Cervin, Gopal K. Chotani, Frank J. Feher, Richard La Duca, Joseph C. McAuliffe, Andrei Miasnikov, Caroline M. Peres, Aaron S. Puhala, Karl J. Sanford, Fernando Valle, Gregory M. Whited
  • Publication number: 20140080983
    Abstract: This invention relates to compositions and methods for producing polymers of isoprene derived from renewable resources, such as isoprene produced from cultured cells that use renewable carbon sources. A starting isoprene composition, such as a bioisoprene composition, is distinguished from petroleum based isoprene by its purity profile (such as lower levels of certain C5 hydrocarbons other than isoprene, presence of certain compounds associated with the biological process for production) and the relative content of the carbon isotopes. Polymers obtained by polymerization of such starting isoprene composition according to this invention, such as a polyisoprene homopolymer or a copolymer having repeat units that are derived from isoprene, are distinguishable from isoprene containing polymers from petrochemical resources.
    Type: Application
    Filed: August 20, 2013
    Publication date: March 20, 2014
    Applicants: DANISCO US INC., THE GOODYEAR TIRE & RUBBER COMPANY
    Inventors: Joseph C. McAuliffe, Sergey Paramonov, Stephan Rodewald, Karl J. Sanford
  • Publication number: 20130309743
    Abstract: The present invention provides methods for producing derivatives from cultured cells. In addition, the present invention provides methods for conversion of prenyl derivatives, obtained from biological or petrochemical sources, to isoprene by employing chemical or biological catalysts. The present invention also provides compositions that include the cultured cells or isoprene or prenyl derivatives produced there from.
    Type: Application
    Filed: June 6, 2013
    Publication date: November 21, 2013
    Applicants: THE GOODYEAR TIRE & RUBBER COMPANY, DANISCO US INC.
    Inventors: Joseph C. MCAULIFFE, Samira RATHNAYAKE, Karl J. SANFORD
  • Publication number: 20130280778
    Abstract: The present invention provides methods for increasing the amount of isoprene produced by cultured cells with only a minimal increase in carbon dioxide emitted, thereby resulting in process having a greater yield of isoprene relative to carbon dioxide. In addition, the present invention provides compositions that include the cultured cells or isoprene produced there from.
    Type: Application
    Filed: May 21, 2013
    Publication date: October 24, 2013
    Inventors: Gopal K. CHOTANI, Alex T. NIELSEN, Karl J. SANFORD
  • Patent number: 8546506
    Abstract: The invention features compositions and methods for producing polymers of isoprene derived from renewable resources such as isoprene produced from cultured cells that use renewable carbon sources. A starting isoprene composition, such as a bioisoprene composition, is distinguished from petroleum based isoprene by the purity profile (such as lower levels of certain C5 hydrocarbons other than isoprene, presence of certain compounds associated with the biological process for production) and the relative content of the carbon isotopes. Polymers obtained by polymerization of such starting isoprene composition according to this invention, such as a polyisoprene homopolymer or a copolymer having repeat units that are derived from isoprene, are distinguishable from isoprene containing polymers from petrochemical resources.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: October 1, 2013
    Assignees: The Goodyear Tire & Rubber Company, Danisco US Inc.
    Inventors: Joseph C. McAuliffe, Sergey Paramonov, Stephan Rodewald, Karl J. Sanford
  • Publication number: 20130253141
    Abstract: It has been found that certain cells in culture can convert more than about 0.002 percent of the carbon available in the cell culture medium into isoprene. These cells have a heterologous nucleic acid that (i) encodes an isoprene synthase polypeptide and (ii) is operably linked to a promoter. The isoprene produced in such a cultured medium can then be recovered and polymerized into synthetic rubbers and other useful polymeric materials. The synthetic isoprene containing polymers of this invention offer the benefit of being verifiable as to being derived from non-petrochemical based resources. They can also be analytically distinguished from rubbers that come from natural sources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has ?13C value of greater than ?22‰.
    Type: Application
    Filed: March 11, 2013
    Publication date: September 26, 2013
    Applicants: DANISCO US INC., THE GOODYEAR TIRE & RUBBER COMPANY
    Inventors: Frank J. Feher, Gregory M. Whited, Gopal K. Chotani, Fernando Valle, Carol Fioresi, Karl J. Sanford, Joseph McAuliffe, Marguerite Cervin, Aaron S. Puhala, Andrei Miasnikov, Ilana S. Aldor
  • Patent number: 8476049
    Abstract: The present invention provides methods for producing derivatives from cultured cells. In addition, the present invention provides methods for conversion of prenyl deerivatives, obtained from biological or petrochemical sources, to isoprene by employing chemical or biological catalysts. The present invention also provides compositions that include the cultured cells or isoprene or prenyl derivatives produced there from.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: July 2, 2013
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Joseph C. McAuliffe, Samira Rathnayake, Karl J. Sanford
  • Patent number: 8470581
    Abstract: The present invention provides methods for increasing the amount of isoprene produced by cultured cells with only a minimal increase in carbon dioxide emitted, thereby resulting in process having a greater yield of isoprene relative to carbon dioxide. In addition, the present invention provides compositions that include the cultured cells or isoprene produced there from.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: June 25, 2013
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Gopal K. Chotani, Alex Nielsen, Karl J. Sanford
  • Patent number: 8450549
    Abstract: The invention provides for methods, compositions and systems using bioisoprene derived from renewable carbon for production of a variety of hydrocarbon fuels and fuel additives.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: May 28, 2013
    Assignee: Danisco US Inc.
    Inventors: Joseph C. McAuliffe, Sergey E. Paramonov, Karl J. Sanford
  • Patent number: 8420360
    Abstract: The invention features methods for producing isoprene from cultured cells wherein the cells in the stationary phase. The invention also provides compositions that include these cultured cells and/or increased amount of isoprene. The invention also provides for systems that include a non-flammable concentration of isoprene in the gas phase. Additionally, the invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: April 16, 2013
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Anthony R. Calabria, Marguerite A. Cervin, Gopal K. Chotani, Richard La Duca, Joseph C. McAuliffe, Michael C. Miller, Timothy A. Sabo, Karl J. Sanford, Erin L. Webster, Gregory M. Whited
  • Patent number: 8420759
    Abstract: It has been found that certain cells in culture can convert more than about 0.002 percent of the carbon available in the cell culture medium into isoprene. These cells have a heterologous nucleic acid that (i) encodes an isoprene synthase polypeptide and (ii) is operably linked to a promoter. The isoprene produced in such a cultured medium can then be recovered and polymerized into synthetic rubbers and other useful polymeric materials. The synthetic isoprene containing polymers of this invention offer the benefit of being verifiable as to being derived from non-petrochemical based resources. They can also be analytically distinguished from rubbers that come from natural sources. The present invention more specifically discloses a polyisoprene polymer which is comprised of repeat units that are derived from isoprene monomer, wherein the polyisoprene polymer has ?13C value of greater than ?22‰.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: April 16, 2013
    Assignees: The Goodyear Tire & Rubber Company, Danisco US, Inc.
    Inventors: Frank J. Feher, Gregory M. Whited, Gopal K. Chotani, Fernando Valle, Carol Fioresi, Karl J. Sanford, Joseph C. McAuliffe, Marguerite Cervin, Aaron S. Puhala, Andrei Miasnikov, Ilana S. Aldor
  • Publication number: 20130078699
    Abstract: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
    Type: Application
    Filed: August 30, 2012
    Publication date: March 28, 2013
    Applicants: The Goodyear Tire & Rubber Company, Danisco US Inc.
    Inventors: Marguerite A. CERVIN, Gopal K. Chotani, Frank J. Feher, Richard La Duca, Joseph C. McAuliffe, Andrei Miasnikov, Caroline M. Peres, Aaron S. Puhala, Karl J. Sanford, Fernando Valle, Gregory M. Whited
  • Publication number: 20130071908
    Abstract: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
    Type: Application
    Filed: August 30, 2012
    Publication date: March 21, 2013
    Applicants: The Goodyear Tire & Rubber Company, Danisco US Inc.
    Inventors: Marguerite A. CERVIN, Gregory M. Whited, Gopal K. Chotani, Fernando Valle, Karl J. Sanford, Joseph C. McAuliffe, Frank J. Feher, Aaron S. Puhala, Andrei Miasnikov, Richard La Duca, Caroline M. Peres