Patents by Inventor Karl-Josef Abel

Karl-Josef Abel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid encoding a signal peptide, a recombinant molecule comprising the nucleic acid, methods of using the nucleic acid, and methods of using the signal peptide
    Patent number: 5580758
    Abstract: The invention relates to a nucleic acid encoding a signal peptide from Bordetella pertussis, a recombinant molecule comprising the signal peptide, and processes for optimizing protein expression in Gram-negative bacteria employing the nucleic acid or signal peptide.
    Type: Grant
    Filed: February 7, 1995
    Date of Patent: December 3, 1996
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Stefan Knapp, Egon Amann, Karl-Josef Abel
  • DNA encoding anticoagulative protein PP4-X, and its preparation and use
    Patent number: 5320950
    Abstract: The protein PP4-X, whose amino acid sequence and the DNA sequence coding for this have been determined, has anticoagulative properties and can be prepared by genetic manipulation. PP4-X is used for therapeutic and diagnostic purposes.
    Type: Grant
    Filed: December 4, 1992
    Date of Patent: June 14, 1994
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Ulrich Grundmann, Karl-Josef Abel, Egon Amann
  • Protein PP 15 preprared by genetic manipulation
    Patent number: 5317094
    Abstract: Specific fragments of the protein PP15 were prepared by enzyme cleavage. Using statistical data, specific oligonucleotides were selected from the oligonucleotides coding for the specific PP15 fragments. These oligonucleotides were then used as probes to successfully screen a cDNA bank of mature human placenta and isolate the complete cDNA of PP15. The cDNA was sequenced and characterized. This cDNA can be used to prepare PP15 protein in prokaryotic or eukaryotic cells.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: May 31, 1994
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Ulrich Grundmann, Karl-Josef Abel, Eugen Amann
  • Anticoagulative protein PP4-X
    Patent number: 5202419
    Abstract: The protein PP4-X, whose amino acid sequence and the DNA sequence coding for this have been determined, has anticoagulative properties and can be prepared by genetic manipulation. PP4-X is used for therapeutic and diagnostic purposes.
    Type: Grant
    Filed: February 28, 1992
    Date of Patent: April 13, 1993
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Ulrich Grundmann, Karl-Josef Abel, Egon Amann
  • Protein PP15 prepared by genetic manipulation
    Patent number: 5188933
    Abstract: The cDNA coding for PP15 is described. This cDNA can be used to prepare PP15 in pro- or eukaryotic cells.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: February 23, 1993
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Ulrich Grundmann, Karl-Josef Abel, Eugen Amann
  • Signal peptide for the secretion of peptides in Escherichia coli
    Patent number: 5159062
    Abstract: The invention relates to a new signal peptide from Bordetella pertussis with the amino acid sequence M K K W F V A A G I G A G L L M L S S A A and to particularly suitable expression vectors with whose aid such signal sequences can be found and/or evaluated.
    Type: Grant
    Filed: January 19, 1990
    Date of Patent: October 27, 1992
    Assignee: Behringwerde Aktiengesellschaft
    Inventors: Stefan Knapp, Egon Amann, Karl-Josef Abel