Abstract: A particle accelerator assembly with a liquid-target holding assembly usable to produce radioisotopes in liquid targets. A particle accelerator is configured to produce a particle beam along a beam axis, and the liquid-target holding assembly connected to the particle accelerator. The liquid-target retaining assembly has a mounting portion coupled to the particle accelerator, and the mounting portion is configured to receive the particle beam therethrough. A liquid-target holder is connected to the mounting portion and has a holder body with a target cavity that contains a liquid target therein. The target cavity has a longitudinal axis oriented at an acute angle relative to the particle beam axis. The target cavity has a first depth along an axis perpendicular to the longitudinal axis and has a projected depth along the beam axis greater than the first depth.