Patents by Inventor Karl Shawn Watts

Karl Shawn Watts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-malarial agents
    Patent number: 11903936
    Abstract: The present invention is related to new pyrrole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrrole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: February 20, 2024
    Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, MMV MEDICINES FOR MALARIA VENTURE
    Inventors: Margaret Phillips, Michael Palmer, Susan A. Charman, Karl Shawn Watts, Aleksey I. Gerasyuto, Goran Krilov
  • ANTI-MALARIAL AGENTS
    Publication number: 20230056202
    Abstract: The present invention is related to new pyrrole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrrole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.
    Type: Application
    Filed: December 18, 2020
    Publication date: February 23, 2023
    Inventors: MARGARET PHILLIPS, MICHAEL PALMER, SUSAN A. CHARMAN, KARL SHAWN WATTS, ALEKSEY I. GERASYUTO, GORAN KRILOV
  • INHIBITORS OF BETA SECRETASE
    Publication number: 20210284659
    Abstract: The present invention relates to tricyclic inhibitors of beta-secretase having the structure shown in Formula (I) and (II) and the tautomers and the stereoisomeric forms thereof, wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, dementia associated with beta-amyloid, age-related macular degeneration, type 2 diabetes and other metabolic disorders.
    Type: Application
    Filed: March 6, 2018
    Publication date: September 16, 2021
    Inventors: Ann Marleen Vos, Daniel Oehlrich, Henricus Jacobus Maria Gijsen, Karl Shawn Watts, Sathesh Pangala Bhat, Peter Jacobus Johannes Antonius Buijnsters, Sven Franciscus Anna Van Brandt, Jesús Manuel Alcázar-Vaca
  • INHIBITORS OF BETA SECRETASE
    Publication number: 20200010482
    Abstract: The present invention relates to tricyclic inhibitors of beta-secretase having the structure shown in Formula (I) and (II) and the tautomers and the stereoisomeric forms thereof, wherein the radicals are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, dementia associated with beta-amyloid, age-related macular degeneration, type 2 diabetes and other metabolic disorders.
    Type: Application
    Filed: March 6, 2018
    Publication date: January 9, 2020
    Inventors: Ann Marleen Vos, Daniel Oehlrich, Henricus Jacobus Maria Gijsen, Karl Shawn Watts, Sathesh Pangala Bhat, Frans Maria Alfons Van den Keybus
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20160296524
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: April 13, 2016
    Publication date: October 13, 2016
    Inventors: Donna L. Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C. Harriman, Alan Franklin Corin, Craig E. Masse, Mee Shelley
  • IRAK inhibitors and uses thereof
    Patent number: 9340554
    Abstract: The present invention provides 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine compounds and pharmaceutical compositions thereof as inhibitors of IRAK.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: May 17, 2016
    Assignee: NIMBUS IRIS, INC.
    Inventors: Donna L. Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C. Harriman, Alan Franklin Corin, Craig E. Masse, Mee Shelley
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20150025093
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 25, 2014
    Publication date: January 22, 2015
    Applicant: Nimbus Iris, Inc.
    Inventors: Donna L. Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C. Harriman, Alan Franklin Corin, Craig E. Masse, Mee Shelley
  • IRAK inhibitors and uses thereof
    Patent number: 8703941
    Abstract: The present invention provides thienopyrimidine and thienopyridine compounds, compositions thereof, and methods of using the same for the treatment of diseases mediated by IRAK enzymes. Such diseases include inflammatory and proliferative diseases.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: April 22, 2014
    Assignee: Nimbus Iris, Inc.
    Inventors: Donna L. Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C. Harriman, Alan Franklin Corin, Craig E. Masse, Mee Shelley
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20120283238
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: January 10, 2012
    Publication date: November 8, 2012
    Applicant: NIMBUS IRIS, INC.
    Inventors: Donna L. Romero, Matthew David Wessel, Shaughnessy Robinson, Jeremy Robert Greenwood, Karl Shawn Watts, Leah Lynn Frye, Geraldine C. Harriman, Alan Franklin Corin, Craig E. Masse