Abstract: Systems and methods detect a target analyte in a breath sample. The system includes a sensor device and an analyzer. The sensor device includes a breath capture mechanism for capturing the target analyte from the breath sample. The captured analyte is transferred to a testing solution. The sensor device includes a receptor for selectively binding the target analyte. The receptor and the bound analyte together form a receptor-analyte complex. The sensor device also includes a sensor. The sensor includes at least one electrode. A surface of the at least one electrode binds the receptor-analyte complex when the sensor is exposed to the testing solution containing the target analyte. The analyzer analyzes the sensor to determine a target analyte level. The analyzer includes an electronics subsystem for determining a change in an electrical property of the sensor caused by the presence of the receptor-analyte complex. The analyzer generates the target analyte level based on the change in the electrical property.