Abstract: The present invention is concerned with solid, single-dose dosage forms for an increased rate of release of slightly soluble active ingredients. The dosage forms are based on a coherent matrix which disintegrates rapidly in physiological fluids. The matrix comprises one or more slightly soluble active ingredients in the form of fast-release micro- or nanocapsules. The dosage form is particularly suitable for administering those slightly soluble active ingredients for which a rapid onset of action is desired.

Abstract: A primary packaging unit for film-like or wafer-like administration forms for oral application with an off-cut of an upper web of packaging material and of an lower web of packaging material is characterized in that a plurality of dosage units of a film-like or wafer-like administration form, individually sealed in flat compartments formed without cold or hot forming of the packaging material and spaced at a distance to one another, are present in a primary packaging unit, and there are perforations between the compartments which enable the separation of individual compartments, if necessary.

Abstract: An osmotic device for the controlled release of active compounds into the fluid of the gastrointestinal tract through an outlet opening arranged in the outer membrane of the device is characterized in that the outlet opening, compared with areas of the device designed to maintain a distance relative to the surface of the mucous membrane, is arranged in a position of the external membrane at a distance from the surface of the mucous membrane which, relatively thereto, is further away.

Abstract: In a solid medicament form for the peroral application of active agents containing a uniform distribution of active agent in a polymer material, the polymer material is in the form of flat fragments.

Abstract: The present invention describes a device for the controlled release of active compounds in the gastrointestinal tract with delayed pyloric passage, having a component expandable on contact with gastric juice, which is surrounded by a polymer covering which is permeable to gastric juice and active compounds. The device contains at least one active compound which is present in a multiparticulate preparation which releases the active compound into the gastric juice with a delay. Compared with conventional pharmaceutical forms with delayed pyloric passage, the release of active compound from a device according to the invention can be better controlled; likewise the device can be easily rolled or folded and can be introduced into capsules without problems.

Abstract: A pharmaceutical lozenge for the modified release of active compounds in the gastrointestinal tract is described, with active-compound-containing particles which have a first coating controlling the release and a further, outer coating with saliva-resistant properties. The first coating, which controls the release of active compound, can have release-delaying or enteric properties.

Abstract: A dry-coated tablet for controlled release of active substance, having an erodible core tablet (1) containing at least one active substance, and a substantially erosion-resistant shell consisting of a dry-coated layer (5), is characterized in that the dry-coated layer (5) has at least one opening (6), and one end of the core tablet (1) extends as far as the opening (6).

Abstract: An oral preparation, comprising at least one pharmaceutical active compound in a matrix which is swellable in aqueous medium, which is released from the matrix into the aqueous medium in a delayed manner on swelling thereof, while the matrix is largely resistant to disintegration during the release process, it is characterized in that it is a layered tablet with layers adhering to one another, of which at least one layer is the swellable matrix layer and at least another layer is an auxiliary and/or excipient layer, and in that the swellable matrix layer contains an amount of crosslinked amylose.

Abstract: A pharmaceutical lozenge for the modified release of active compounds in the gastrointestinal tract is described, with active-compound-containing particles which have a first coating controlling the release and a further, outer coating with saliva-resistant properties. The first coating, which controls the release of active compound, can have release-delaying or enteric properties.

Abstract: A layered tablet for the controlled release of active substances in a liquid medium comprising at least one active substance-containing, layered matrix with contact surfaces to the liquid medium which are at least partially provided with a cover layer delaying or preventing the active substance release, is characterized by the fact that the cover layer is at least one additional layer lying with thickness gradients on contact surfaces of the layered, prefabricated matrix, or that the matrix is at least one additional layer lying with thickness gradients on contact surfaces of the layered, prefabricated cover layer, which additional layer is applied by pressing powdery or granular material on the layered, prefabricated matrix or on the layered, prefabricated cover layer.

Abstract: An oral administration form with a carrier for acid active substances wherein the active substance has at least one free carboxyl group ionically bound to a polymer having tertiary amino groups is characterized by the fact that the polymer is colestipol or colestipol hydrochloride.

Abstract: A device for the controlled release of active substances in liquid media from an active substance-containing matrix exhibiting active substance releasing-surfaces has, the active substance releasing surfaces of the matrix covered, at least partially, by an erodible mass of solids; the thickness of the erodible mass across its extent on the active substance releasing-areas is determined by gradients.