Patents by Inventor Karthik Veeravalli

Karthik Veeravalli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying bacteria comprising binding polypeptides
    Patent number: 11434482
    Abstract: The invention provides methods of identifying bacteria comprising binding polypeptides. The invention also provides methods of identifying bacteria with improved expression of binding polypeptides. The invention also provides methods of identifying binding polypeptides with improved expression. The invention also provides engineered bacteria suitable for use in the methods of the invention. The invention also provides compositions that can be obtained using the methods, for example, anti-interleukin-13 (IL-13) antibodies with improved expression and/or stability. The invention also provides libraries comprising binding polypeptide (e.g., antibody) variants.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: September 6, 2022
    Assignee: Genentech, Inc.
    Inventors: Twyla Noelle Lombana, Rebekah McKenna, Christoph Spiess, Karthik Veeravalli, Michael Dillon
  • METHODS OF PRODUCING TWO CHAIN PROTEINS IN PROKARYOTIC HOST CELLS
    Publication number: 20210261973
    Abstract: Provided herein are methods and host cells for producing a polypeptide containing two chains, such as an antibody, half-antibody, antibody fragment, or one-armed antibody. The methods and host cells allow for two-chain polypeptide production using expression of polynucleotides encoding the polypeptide chains from extra-chromosomal polynucleotide(s), and expression of one or more chaperone protein(s) (e.g., peptidyl-prolyl isomerases and/or protein disulfide oxidoreductases) from the host cell chromosome using non-native combination(s) of promoters and translational units encoding a chaperone protein.
    Type: Application
    Filed: May 4, 2021
    Publication date: August 26, 2021
    Applicant: Genentech, Inc.
    Inventors: Karthik VEERAVALLI, Rebekah MCKENNA
  • Microorganisms comprising a mutant metA allele for reducing norleucine misincorporation into proteins
    Patent number: 11015214
    Abstract: The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: May 25, 2021
    Assignee: Genentech, Inc.
    Inventors: Michael W. Laird, Karthik Veeravalli
  • METHODS AND COMPOSITIONS FOR PREVENTING NORLEUCINE MISINCORPORATION INTO PROTEINS
    Publication number: 20200056218
    Abstract: The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
    Type: Application
    Filed: August 8, 2019
    Publication date: February 20, 2020
    Applicant: Genentech, Inc.
    Inventors: Michael W. LAIRD, Karthik VEERAVALLI
  • Methods for reducing norleucine misincorporation into proteins using a microorganism comprising a mutant metA allele
    Patent number: 10421984
    Abstract: The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: September 24, 2019
    Assignee: Genentech, Inc.
    Inventors: Michael W. Laird, Karthik Veeravalli
  • Compositions for preventing norleucine misincorporation into proteins
    Patent number: 10179925
    Abstract: The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: January 15, 2019
    Assignee: Genentech, Inc.
    Inventors: Michael W. Laird, Karthik Veeravalli
  • METHODS AND COMPOSITIONS FOR PREVENTING NORLEUCINE MISINCORPORATION INTO PROTEINS
    Publication number: 20180230506
    Abstract: The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
    Type: Application
    Filed: April 12, 2018
    Publication date: August 16, 2018
    Applicant: Genentech, Inc.
    Inventors: Michael W. LAIRD, Karthik VEERAVALLI
  • METHODS AND COMPOSITIONS FOR PREVENTING NORLEUCINE MISINCORPORATION INTO PROTEINS
    Publication number: 20180080056
    Abstract: The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
    Type: Application
    Filed: November 17, 2017
    Publication date: March 22, 2018
    Applicant: Genentech, Inc.
    Inventors: Michael W. Laird, Karthik Veeravalli
  • METHODS OF IDENTIFYING BACTERIA COMPRISING BINDING POLYPEPTIDES
    Publication number: 20180030434
    Abstract: The invention provides methods of identifying bacteria comprising binding polypeptides. The invention also provides methods of identifying bacteria with improved expression of binding polypeptides. The invention also provides methods of identifying binding polypeptides with improved expression. The invention also provides engineered bacteria suitable for use in the methods of the invention. The invention also provides compositions that can be obtained using the methods, for example, anti-interleukin-13 (IL-13) antibodies with improved expression and/or stability. The invention also provides libraries comprising binding polypeptide (e.g., antibody) variants.
    Type: Application
    Filed: October 12, 2017
    Publication date: February 1, 2018
    Inventors: Twyla Noelle LOMBANA, Rebekah MCKENNA, Christoph SPIESS, Karthik VEERAVALLI, Michael DILLON
  • Methods and compositions for preventing norleucine misincorporation into proteins
    Patent number: 9850514
    Abstract: The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: December 26, 2017
    Assignee: Genentech, Inc.
    Inventors: Michael W. Laird, Karthik Veeravalli
  • METHODS AND COMPOSITIONS FOR PREVENTING NORLEUCINE MISINCORPORATION INTO PROTEINS
    Publication number: 20160186227
    Abstract: The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
    Type: Application
    Filed: March 11, 2016
    Publication date: June 30, 2016
    Applicant: Genentech, Inc.
    Inventors: Michael W. Laird, Karthik Veeravalli
  • METHODS AND COMPOSITIONS FOR PREVENTING NORLEUCINE MISINCORPORATION INTO PROTEINS
    Publication number: 20140081003
    Abstract: The present invention relates to methods and compositions for preventing incorporation of norleucine into proteins during recombinant protein production in bacteria. The present invention also provides microorganism host cells and nucleic acid molecules for use with the methods and compositions provided herein.
    Type: Application
    Filed: September 19, 2013
    Publication date: March 20, 2014
    Applicant: Genentech, Inc.
    Inventors: Michael W. Laird, Karthik Veeravalli