Patents by Inventor Karthikeyan Kandavelou

Karthikeyan Kandavelou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OBLIGATE HETERODIMER VARIANTS OF FOKI CLEAVAGE DOMAIN
    Publication number: 20160017299
    Abstract: Disclosed are methods of making and using engineered Fold cleavage domain variants. Also disclosed are methods, compositions and fusion proteins containing obligate heterodimers of engineered Fold cleavage domain variants and DNA binding domains, such as zinc finger protein (ZFP) domains and transcription activator-like effector (TALE) domains.
    Type: Application
    Filed: June 8, 2015
    Publication date: January 21, 2016
    Inventors: Srinivasan CHANDRASEGARAN, Sivaprakash RAMALINGAM, Karthikeyan KANDAVELOU
  • Obligate heterodimer variants of foki cleavage domain
    Patent number: 9057057
    Abstract: Disclosed are methods of making and using engineered FokI cleavage domain variants. Also disclosed are methods, compositions and fusion proteins containing obligate heterodimers of engineered FokI cleavage domain variants and DNA binding domains, such as zinc finger protein (ZFP) domains and transcription activator-like effector (TALE) domains.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: June 16, 2015
    Assignees: THE JOHNS HOPKINS UNIVERSITY, PONDICHERRY BIOTECH PRIVATE LIMITED (PBPL)
    Inventors: Srinivasan Chandrasegaran, Sivaprakash Ramalingam, Karthikeyan Kandavelou
  • GENERATION AND USE OF PLURIPOTENT STEM CELLS
    Publication number: 20140127814
    Abstract: ABSTRACT Methods, compositions, constructs, vectors, cell lines, and kits, for generating induced pluripotent stem cells by site-specific integration of pluripotency coding sequences with endonucleases for use in gene therapy, regenerative medicine, cell therapy or drug screening.
    Type: Application
    Filed: August 10, 2011
    Publication date: May 8, 2014
    Inventors: Srinivasan Chandrasegaran, Ramalingam Sivaprakash, Karthikeyan Kandavelou, Viktoriya London
  • OBLIGATE HETERODIMER VARIANTS OF FOKI CLEAVAGE DOMAIN
    Publication number: 20130130350
    Abstract: Disclosed are methods of making and using engineered FokI cleavage domain variants. Also disclosed are methods, compositions and fusion proteins containing obligate heterodimers of engineered FokI cleavage domain variants and DNA binding domains, such as zinc finger protein (ZFP) domains and transcription activator-like effector (TALE) domains.
    Type: Application
    Filed: July 27, 2011
    Publication date: May 23, 2013
    Inventors: Srinivasan Chandrasegaran, Sivaprakash Ramalingam, Karthikeyan Kandavelou