Patents by Inventor Karuppiah Muthumani

Karuppiah Muthumani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION OF NOVEL VACCINES AGAINST ZIKA VIRUS AND DNA ANTIBODY CONSTRUCTS FOR USE AGAINST ZIKA VIRUS
    Publication number: 20240131154
    Abstract: Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
    Type: Application
    Filed: September 28, 2023
    Publication date: April 25, 2024
    Inventors: David Weiner, Karuppiah Muthumani, Jian Yan
  • MERS-CoV Vaccine
    Publication number: 20240123056
    Abstract: Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. Also disclosed herein is a method of treating a subject in need thereof, by administering the vaccine to the subject.
    Type: Application
    Filed: September 28, 2023
    Publication date: April 18, 2024
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Y. Sardesai
  • DNA antibody constructs encoding anti-ZIKV envelope antibodies
    Patent number: 11925685
    Abstract: Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: March 12, 2024
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc., The Wistar Institute of Anatomy and Biology
    Inventors: David Weiner, Karuppiah Muthumani, Jian Yan
  • MERS-CoV vaccine
    Patent number: 11801298
    Abstract: Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. Also disclosed herein is a method of treating a subject in need thereof, by administering the vaccine to the subject.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: October 31, 2023
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Y. Sardesai
  • DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME
    Publication number: 20230023093
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: March 3, 2022
    Publication date: January 26, 2023
    Inventors: David B. Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • CANCER VACCINES AND METHODS OF TREATMENT USING THE SAME
    Publication number: 20230012022
    Abstract: Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.
    Type: Application
    Filed: July 20, 2022
    Publication date: January 12, 2023
    Inventors: David B. Weiner, Jian Yan, Karuppiah Muthumani, Jewell Walters
  • Cancer vaccines and methods of treatment using the same
    Patent number: 11419925
    Abstract: Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 23, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Jian Yan, Karuppiah Muthumani, Jewell Walters
  • DNA Antibody Constructs And Method Of Using Same
    Publication number: 20220112273
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 14, 2022
    Inventors: David Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • DNA antibody constructs and method of using same
    Patent number: 11278619
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: March 22, 2022
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David B. Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • Foot and Mouth Disease Virus (FMDV) Consensus Proteins, Coding Sequences Therefor and Vaccines Made Therefrom
    Publication number: 20220009971
    Abstract: Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
    Type: Application
    Filed: September 14, 2021
    Publication date: January 13, 2022
    Inventors: David B. Weiner, Bernadette Ferraro, Jian Yan, Patricia A. Brown, Rodney A. Bowling, Douglas R. Kern, Mathura P. Ramanathan, Niranjan Y. Sardesai, Karuppiah Muthumani
  • Checkpoint Inhibitor and Vaccine Combinations and Use of Same for Immunotherapy
    Publication number: 20210401978
    Abstract: Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: September 14, 2021
    Publication date: December 30, 2021
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Sardesai
  • MERS-CoV Vaccine
    Publication number: 20210401972
    Abstract: Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. Also disclosed herein is a method of treating a subject in need thereof, by administering the vaccine to the subject.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 30, 2021
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Y. Sardesai
  • DNA antibody constructs and method of using same
    Patent number: 11208470
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: December 28, 2021
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • Immunogenicity of an optimized synthetic consensus DNA vaccine for porcine epidemic diarrhea virus
    Patent number: 11179458
    Abstract: Provided herein is a vaccine comprising a Porcine Epidemic Diarrhea Virus (PEDV) antigen. The antigen can be a consensus antigen. Also disclosed herein is a method of treating a porcine in need thereof, by administering the vaccine to the porcine.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: November 23, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David Weiner, Emma L. Reuschel, Karuppiah Muthumani
  • MERS-CoV vaccine
    Patent number: 11135284
    Abstract: Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. Also disclosed herein is a method of treating a subject in need thereof, by administering the vaccine to the subject.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: October 5, 2021
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Y. Sardesai
  • Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom
    Patent number: 11124545
    Abstract: Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: September 21, 2021
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David B. Weiner, Bernadette Ferraro, Jian Yan, Patricia A. Brown, Rodney A. Bowling, Douglas R. Kern, Mathura P. Ramanathan, Niranjan Y. Sardesai, Karuppiah Muthumani
  • Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy
    Patent number: 11116838
    Abstract: Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: September 14, 2021
    Assignees: The Trustees of the University of Pennsylvania, INOVIO PHARMACEUTICALS, INC.
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Sardesai
  • Vaccines with biomolecular adjuvants
    Patent number: 11027011
    Abstract: Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: June 8, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Karuppiah Muthumani
  • PD1 AND PDL1 ANTIBODIES AND VACCINE COMBINATIONS AND USE OF SAME FOR IMMUNOTHERAPY
    Publication number: 20210085779
    Abstract: Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: October 6, 2020
    Publication date: March 25, 2021
    Inventors: David WEINER, Karuppiah MUTHUMANI, Niranjan SARDESAI
  • PD1 and PDL1 antibodies and vaccine combinations and use of same for immunotherapy
    Patent number: 10835595
    Abstract: Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: November 17, 2020
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, INOVIO PHARMACEUTICALS, INC.
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Sardesai