Abstract: Embodiments of the present invention provide a prophylactic undergarment system made from soft, stretchable, fluid proof, stain resistant, anti-static, noise-free, high performance medical material that can be washed and reused. The system includes a condom-retaining device and is worn in conjunction with a condom during sexual activity to provide a protective barrier over the entire genital region. The system may also include a pouch for maintaining a condom in a convenient location. The undergarment system reduces skin-to-skin contact and the exchange of bodily fluids beyond typical condom coverage, which prevents the transmission of sexual diseases commonly passed or “shed” around the unprotected genital areas.