Patents by Inventor Kashan Ali Shaikh
Kashan Ali Shaikh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240102882Abstract: A method for assessing the integrity of a bioprocessing system includes the steps of determining a mass of a first container, transferring a volume of fluid from the first container to a second container, determining the mass of the second container, comparing the mass of the first container with the mass of the second container, and, if the difference between the mass of the first container and the mass of the second container exceeds a threshold, generating a notification indicating that a leak is present.Type: ApplicationFiled: December 14, 2021Publication date: March 28, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: ANDREU FONTOVA SOSA, KASHAN ALI SHAIKH, PANTELEIMON ZOTOS
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Publication number: 20240018457Abstract: A method for bioprocessing includes the steps of providing a bioprocessing system having a first bioreactor vessel and a second bioreactor vessel, activating a population of cells in the first bioreactor vessel, genetically modifying the population of cells to produce a population of genetically modified cells, and expanding the population of genetically modified cells within the first bioreactor vessel and the second bioreactor vessel.Type: ApplicationFiled: December 14, 2021Publication date: January 18, 2024Applicants: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC, KITE PHARMA, INC.Inventors: PANTELEIMON ZOTOS, YARDEN SIVAN GRATCH, ISABELLE DALLE FUSINE, KASHAN ALI SHAIKH, ALICJA MARIA KROL, NATE W. FREUND, ERWIN V. CAMMAART, ANTHONY P. SWANDA
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Publication number: 20240002777Abstract: A kit for magnetic cell isolation includes first stopcock manifold having at least four stopcocks, a separation chamber configured for use with a centrifugal processing chamber of the cell processing device, the separation chamber in fluid communication with the first stopcock manifold, a mixing bag configured for use with a heating/cooling mixing chamber of a cell processing device, the mixing bag in fluid communication with the first stopcock manifold, a second stopcock manifold having at least four stopcocks, the second stopcock manifold in fluid communication with the first stopcock manifold, a magnetic cell isolation holder in fluid communication with the second stopcock manifold, the magnetic cell isolation holder configured for use with a magnetic field generator of a magnetic cell isolation device, and a plurality of cell processing bags in fluid communication with the first and/or second stopcock manifolds.Type: ApplicationFiled: December 14, 2021Publication date: January 4, 2024Applicants: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC, KITE PHARMA, INC.Inventors: PIERRE-YVES CHASSOT, OLIVER LINK, FEDERICO ZANONI, MARK TIMMINS, KASHAN ALI SHAIKH, MARINE DE LAGENESTE, DENNIS CHEROK, YANN THOUEMENT, YORICK HEIMBERG, BERTRAND FOUCAUT, JULIEN CAMISANI, KENT YOUNG, SIMON GARDINER, ANTHONY P. SWANDA
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Publication number: 20240002775Abstract: A method for assessing the integrity of a bioprocessing system includes the steps of utilizing a pump of a bioprocessing system, pressurizing a plurality of flow lines, and measuring a decay of a pressure within the plurality of flow lines for a predetermined a duration.Type: ApplicationFiled: December 14, 2021Publication date: January 4, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: ANDREU FONTOVA SOSA, KASHAN ALI SHAIKH, PANTELEIMON ZOTOS, MARK TIMMINS
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Patent number: 11826760Abstract: A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit. A bottom surface of the fluidic handling unit is configured to complementary mate with a top surface of the flow cell carrier, or wherein a bottom surface of the flow cell carrier is configured to complementarily mate with a top surface of the fluidic handling unit.Type: GrantFiled: July 15, 2022Date of Patent: November 28, 2023Assignee: LEICA MICROSYSTEMS CMS GMBHInventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Patent number: 11821891Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: GrantFiled: December 7, 2020Date of Patent: November 21, 2023Assignee: General Electric CompanyInventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Publication number: 20220347691Abstract: A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit. A bottom surface of the fluidic handling unit is configured to complementary mate with a top surface of the flow cell carrier, or wherein a bottom surface of the flow cell carrier is configured to complementarily mate with a top surface of the fluidic handling unit.Type: ApplicationFiled: July 15, 2022Publication date: November 3, 2022Inventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Patent number: 11446671Abstract: Systems and methods for processing biological specimens are provided. The biological specimen processing system generally includes a flow cell carrier for holding a microfluidic flow cell and a fluidic handling unit attachable to the flow cell carrier. The fluidic handling unit interfaces with the microfluidic flow cell and can include fluidic pumps, fluidic connections, integrated electronics, and processing software to facilitate processing of a biological specimen contained in the microfluidic flow cell.Type: GrantFiled: March 14, 2017Date of Patent: September 20, 2022Assignee: LEICA MICROSYSTEMS CMS GMBHInventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Patent number: 11027239Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.Type: GrantFiled: October 5, 2017Date of Patent: June 8, 2021Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Chengkun Zhang, Kashan Ali Shaikh, Reginald Donovan Smith, Weston Blaine Griffin
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Publication number: 20210088503Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: ApplicationFiled: December 7, 2020Publication date: March 25, 2021Inventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Patent number: 10859563Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: GrantFiled: December 1, 2015Date of Patent: December 8, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Patent number: 10365190Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.Type: GrantFiled: January 11, 2016Date of Patent: July 30, 2019Assignee: Whatman International LimitedInventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
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Publication number: 20190105609Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.Type: ApplicationFiled: October 5, 2017Publication date: April 11, 2019Inventors: Chengkun Zhang, Kashan Ali Shaikh, Reginald Donovan Smith, Weston Blaine Griffin
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Publication number: 20190091696Abstract: Systems and methods for processing biological specimens are provided. The biological specimen processing system generally includes a flow cell carrier for holding a microfluidic flow cell and a fluidic handling unit attachable to the flow cell carrier. The fluidic handling unit interfaces with the microfluidic flow cell and can include fluidic pumps, fluidic connections, integrated electronics, and processing software to facilitate processing of a biological specimen contained in the microfluidic flow cell.Type: ApplicationFiled: March 14, 2017Publication date: March 28, 2019Inventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Patent number: 10175174Abstract: Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample including multiple targets, binding at least one probe to one or more target present in the sample, and detecting a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent, as well as an optional additive which prevents target modification during photoactivated chemical bleaching, and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and detecting a signal from the probe. The process of binding, defecting and bleaching may be iteratively repeated.Type: GrantFiled: December 11, 2013Date of Patent: January 8, 2019Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Arunkumar Natarajan, Robert John Filkins, Anup Sood, Lakshmi Sireesha Kaanumalle, Kashan Ali Shaikh, Christina Lowes
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Patent number: 9817221Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.Type: GrantFiled: June 26, 2013Date of Patent: November 14, 2017Assignee: General Electric CompanyInventors: Alex David Corwin, Robert John Filkins, Jun Xie, Nannan Chen, Kashan Ali Shaikh
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Publication number: 20170153223Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: ApplicationFiled: December 1, 2015Publication date: June 1, 2017Inventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Publication number: 20160282241Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.Type: ApplicationFiled: January 11, 2016Publication date: September 29, 2016Inventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
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Publication number: 20160123926Abstract: A method of isolating nucleic acids from a biological material, comprises applying the biological material on a substrate comprising one or more cell lysis reagents impregnated therein; applying a fluid to the biological material applied on the substrate; extracting the nucleic acids from the biological material applied on the substrate; and collecting the extracted nucleic acids in a substantially intact form, wherein the collected nucleic acid has a molecular weight greater than or equal to 20 kb.Type: ApplicationFiled: September 25, 2015Publication date: May 5, 2016Inventors: John Richard Nelson, Christopher Michael Puleo, Erin Jean Finehout, Patrick McCoy Spooner, Kashan Ali Shaikh, Xiaohui Chen, Li Zhu
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Patent number: 9254484Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.Type: GrantFiled: March 10, 2014Date of Patent: February 9, 2016Assignee: WHATMAN INTERNATIONAL LIMITEDInventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard