Patents by Inventor Kate Welsh

Kate Welsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE
    Publication number: 20110183358
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Application
    Filed: March 17, 2006
    Publication date: July 28, 2011
    Applicants: THE BURNHAM INSTITUTE, TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Kate Welsh, Clemencia Pinilla
  • Methods and compositions for derepression of IAP-inhibited caspase
    Publication number: 20090043099
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Application
    Filed: October 31, 2007
    Publication date: February 12, 2009
    Applicant: The Burnham Institute
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Clemencia Pinilla, Kate Welsh
  • Methods and compositions for derepression of IAP-inhibited caspase
    Patent number: 7217688
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: May 15, 2007
    Assignees: The Burnham Institute, Torrey Pines Institute for Molecular Studies
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Clemencia Pinilla, Kate Welsh
  • Methods and compositions for derepression of IAP-inhibited caspase
    Publication number: 20070003535
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Application
    Filed: March 17, 2005
    Publication date: January 4, 2007
    Inventors: John Reed, Richard Houghten, Adel Nefzi, John Ostresh, Clemencia Pinilla, Kate Welsh
  • Methods and composition for derepressions of IAP-inhibited caspase
    Publication number: 20060258581
    Abstract: The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in FIGS. 5, 9, 10, 14B, 21-24 and 48, a core structure selected from the group of TPI 759, TPI 882, TPI 914 or TPI 927; and a core structure from a library selected from TPI 1391, TPI 1349, TPI 1396, TPI 1509, TPI 1540, TPI 1400, TPI 792, TPI 1332, TPI 1567, TPI 1576 and TPI 1577, wherein the agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase.
    Type: Application
    Filed: October 14, 2005
    Publication date: November 16, 2006
    Inventors: John Reed, Richard Houghten, Adel Nefzi, John Ostresh, Clemencia Pinilla, Kate Welsh
  • Methods and compositions for derepression of IAP-inhibited caspase
    Publication number: 20060211627
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Application
    Filed: July 19, 2005
    Publication date: September 21, 2006
    Inventors: John Reed, Richard Houghten, Adel Nefzi, John Ostresh, Clemencia Pinilla, Kate Welsh
  • Methods and compositions for derepression of IAP-inhibited caspase
    Publication number: 20050159359
    Abstract: The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in FIGS. 5, 9, 10, 14B, and 21-24 wherein said agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The method consists of contacting an IAP-inhibited caspase with an effective amount of an agent to derepress an IAP-inhibited caspase, the agent having a core motif selected from the group consisting of a core peptide having a sequence set forth in any of Core peptides 4 through 39 and 42 through 55, and a core structure selected from the group consisting of TPI759, TPI882, TPI914 or TPI927.
    Type: Application
    Filed: December 23, 2004
    Publication date: July 21, 2005
    Applicant: The Burnham Institute
    Inventors: John Reed, Richard Houghten, Adel Nefzi, John Ostresh, Clemencia Pinilla, Kate Welsh
  • Methods and compositions for derepression of IAP-inhibited caspase
    Patent number: 6911426
    Abstract: The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in FIGS. 5, 9, 10, 14B, and 21-24 wherein said agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The method consists of contacting an IAP-inhibited caspase with an effective amount of an agent to derepress an IAP-inhibited caspase, the agent having a core motif selected from the group consisting of a core peptide having a sequence set forth in any of Core peptides 4 through 39 and 42 through 55, and a core structure selected from the group consisting of TPI759, TPI882, TPI914 or TPI927.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: June 28, 2005
    Assignees: The Burnham Institute, Torrey Pines Institute for Molecular Studies
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Clemencia Pinilla, Kate Welsh
  • Methods and compositions for derepression of IAP-inhibited caspase
    Publication number: 20050119176
    Abstract: The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in FIGS. 5, 9, 10, 14B, and 21-24, a core structure selected from the group of TPI 759, TPI 882, TPI 914 or TPI 927; and a core structure from a library selected from TPI 1391, TPI 1349, TPI 1396, TPI 1509, TPI 1540, TPI 1400, TPI 792 and TPI 1332, wherein the agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase.
    Type: Application
    Filed: December 24, 2003
    Publication date: June 2, 2005
    Inventors: John Reed, Richard Houghten, Adel Nefzi, John Ostresh, Clemencia Pinilla, Kate Welsh
  • Methods and compositions for derepression of IAP-inhibited caspase
    Publication number: 20030180805
    Abstract: The invention provides isolated agents having a core peptide selected from the group consisting of Core peptides 5 through 39 and 42 through 55, wherein the agent derepresses an IAP-inhibited caspase. Also provided is an isolated agent having a core structure selected from any of the structures shown in FIGS. 5, 9, 10, 14B, and 21-24 wherein said agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The method consists of contacting an IAP-inhibited caspase with an effective amount of an agent to derepress an IAP-inhibited caspase, the agent having a core motif selected from the group consisting of a core peptide having a sequence set forth in any of Core peptides 4 through 39 and 42 through 55, and a core structure selected from the group consisting of TPI759, TPI882, TPI914 or TPI927.
    Type: Application
    Filed: November 21, 2002
    Publication date: September 25, 2003
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Clemencia Pinilla, Kate Welsh