Patents by Inventor Katharina Schmid
Katharina Schmid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8460743Abstract: The present invention generally relates to a method for coating ophthalmic lenses, preferably contact lenses, more preferably silicone hydrogel contact lenses. In particular, the present invention is directed to a method for forming a coating comprising a polyionic material on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user.Type: GrantFiled: March 16, 2009Date of Patent: June 11, 2013Assignee: Novartis AGInventors: Achim Müller, Katharina Schmid
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Patent number: 8206622Abstract: The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the microspheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.Type: GrantFiled: February 22, 2005Date of Patent: June 26, 2012Assignee: EyeSense AGInventors: Stefan Kammermeier, Till Merkel, Katharina Schmid, Achim Müller
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Patent number: 8158192Abstract: The invention relates to a process for the manufacture of a hydrophilic coating on a biomedical article, which comprises treating the biomedical article for a time period of ?5 minutes with a solution of an organic solvent comprising a polyanionic compound with a number average molecular weight Mn of >5000, wherein the solution comprises less than 10% by weight of water, and wherein the solution is devoid of a cationic polymer. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.Type: GrantFiled: December 19, 2007Date of Patent: April 17, 2012Assignee: Novartis AGInventors: Harald Bothe, Yasuo Matsuzawa, Bernhard Seiferling, Katharina Schmid, Heike Arndt
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Patent number: 8147897Abstract: A method for making an article comprising a core material and a coating thereon, the method comprising the steps of: (a) providing the core material; (b) applying one or more layers of a crosslinkable polycationic material, wherein the polycationic material is a reaction product of: (i) an epoxide of formula (I) wherein X equals bromo, chloro, iodo, or cyano, and R1, R2, R3, R4, independently of one another, are selected from the group consisting of hydrogen, linear or branched C1-C6-alkyl, and linear or branched C1-C6-alkyl which is substituted with halogen, and (ii) a polymer having repeating units comprising one or more secondary or tertiary amine group(s); (c) applying one or more layers of a polyanionic material; and (d) cross-linking the layers of polyelectrolytes formed by steps (b) and (c).Type: GrantFiled: February 6, 2008Date of Patent: April 3, 2012Assignee: Novartis AGInventors: Maria Gonzalez Ferreiro, Lutz Kröhne, Achim Müller, Katharina Schmid, Andreas Voigt
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Patent number: 7858337Abstract: The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.Type: GrantFiled: March 3, 2008Date of Patent: December 28, 2010Assignee: Novartis AGInventors: Achim Müller, Monika Knuth, Katharina Schmid, Ralf Pasternack, Jens Zotzel, Kai Oertel, Christine Reiff, geb. Schmitt, Hans-Lothar Fuchsbauer
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Patent number: 7772286Abstract: The present invention relates to a copolymer, which is the reaction product of (a) a first prepolymer, comprising a bioactive moiety and at least one radically polymerizable group, and (b) a second prepolymer which is a polyvinyl alcohol having a weight average molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprises from 0.5 to 80% structural units of formula (I) wherein: R is alkylene having up to 8 carbon atoms, R1 is hydrogen or alkyl having up to seven carbon atoms, and R2 is an olefinically unsaturated, electron-attracting copolymerizable radical.Type: GrantFiled: February 27, 2004Date of Patent: August 10, 2010Assignee: Eyesense AGInventors: Achim Müller, Roland Schmieder, Katharina Schmid
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Publication number: 20090238948Abstract: The present invention generally relates to a method for coating ophthalmic lenses, preferably contact lenses, more preferably silicone hydrogel contact lenses. In particular, the present invention is directed to a method for forming a coating comprising a polyionic material on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user.Type: ApplicationFiled: March 16, 2009Publication date: September 24, 2009Inventors: Achim Muller, Katharina Schmid
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Publication number: 20090029413Abstract: The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking said water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.Type: ApplicationFiled: March 3, 2008Publication date: January 29, 2009Inventors: Achim Muller, Monika Knuth, Katharina Schmid, Ralf Pasternack, Jens Zotzel, Kai Oertel, Christine Reiff, geb. Schmitt, Hans-Lothar Fuchsbauer
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Patent number: 7429465Abstract: The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of (a) physically or chemically inducing a volume reduction of the hydrogel contact lens and thereby squeezing the analyte out of the polymer material making up the contact lens and (b) feeding the analyte obtained according to step (a) into an analyzer. The process of the invention provides a new concept for noninvasively measuring various analytes occurring in the tear fluid that is comfortable to the user.Type: GrantFiled: September 3, 2003Date of Patent: September 30, 2008Assignee: Novartis AGInventors: Achim Müller, Roland Schmieder, Katharina Schmid
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Publication number: 20080226922Abstract: A method for making an article comprising a core material and a coating thereon, the method comprising the steps of: (a) providing the core material; (b) applying one or more layers of a crosslinkable polycationic material, wherein the polycationic material is a reaction product of: (i) an epoxide of formula (I) wherein X equals bromo, chloro, iodo, or cyano, and R1, R2, R3, R4, independently of one another, are selected from the group consisting of hydrogen, linear or branched C1-C6-alkyl, and linear or branched C1-C6-alkyl which is substituted with halogen, and (ii) a polymer having repeating units comprising one or more secondary or tertiary amine group(s); (c) applying one or more layers of a polyanionic material; and (d) cross-linking the layers of polyelectrolytes formed by steps (b) and (c).Type: ApplicationFiled: February 6, 2008Publication date: September 18, 2008Inventors: Maria Gonzalez Ferreiro, Lutz Krohne, Achim Muller, Katharina Schmid, Andreas Voigt
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Publication number: 20080152800Abstract: The invention relates to a process for the manufacture of a hydrophilic coating on a biomedical article, which comprises treating the biomedical article for a time period of ?5 minutes with a solution of an organic solvent comprising a polyanionic compound with a number average molecular weight Mn of >5000, wherein the solution comprises less than 10% by weight of water, and wherein the solution is devoid of a cationic polymer. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.Type: ApplicationFiled: December 19, 2007Publication date: June 26, 2008Inventors: Harald Bothe, Yasuo Matsuzawa, Bernhard Seiferling, Katharina Schmid, Heike Arndt
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Publication number: 20070178162Abstract: The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the micro-spheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.Type: ApplicationFiled: February 22, 2005Publication date: August 2, 2007Applicant: EYESENSE AGInventors: Stefan Kammermeier, Till Merkel, Katharina Schmid, Achim Muller
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Publication number: 20060148983Abstract: The present invention relates to a copolymer, which is the reaction product of (a) a first prepolymer, comprising a bioactive moiety and at least one radically polymerizable group, and (b) a second prepolymer which is a polyvinyl alcohol having a weight average molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprises from 0.5 to 80% structural units of formula (I) wherein: R is alkylene having up to 8 carbon atoms, R1 is hydrogen or alkyl having up to seven carbon atoms, and R2 is an olefinically unsaturated, electron-attracting copolymerizable radical.Type: ApplicationFiled: February 27, 2004Publication date: July 6, 2006Inventors: Achim Muller, Roland Schmieder, Katharina Schmid
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Publication number: 20050176158Abstract: The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of (a) physically or chemically inducing a volume reduction of the hydrogel contact lens and thereby squeezing the analyte out of the polymer material making up the contact lens and (b) feeding the analyte obtained according to step (a) into an analyzer. The process of the invention provides a new concept for noninvasively measuring various analytes occurring in the tear fluid that is comfortable to the user.Type: ApplicationFiled: September 3, 2003Publication date: August 11, 2005Inventors: Achim Muller, Roland Schmieder, Katharina Schmid