Abstract: Disclosed is a polypeptide that includes amino acids 183-222 of CRIF, wherein the polypeptide does not include the full length CRIF1 amino acid sequence. Also disclosed is a nucleic acid molecule encoding this polypeptide, vectors including this nucleic acid molecule, and host cells transformed with these vectors. In some embodiments, methods are disclosed for treating a subject with cancer, comprising administering to the subject a therapeutically effective amount of an inhibitor of CDK12/CRIF1 interaction, thereby treating the cancer in the subject. In specific non-limiting examples, these methods can utilize CRIF1 polypeptides, nucleic acids encoding these polypeptides, and vectors including these nucleic acids.

Abstract: Provided herein are methods and compositions for modulating apoptosis by targeting SKIP (Ski-interacting protein) activity. Methods of increasing DNA damage-induced cell death in cancer cells, and reducing DNA damage-induced cell death in normal cells are provided.

Abstract: Provided herein are methods and compositions for modulating apoptosis by targeting SKIP (Ski-interacting protein) activity. Methods of increasing DNA damage-induced cell death in cancer cells, and reducing DNA damage-induced cell death in normal cells are provided.

Abstract: During an instant message conversation, instant message users may be presented with advertisements, news headlines, hyperlinks to web pages, and other additional information. It may be advantageous to provide targeted information that may be relevant to the current conversation between the instant message users. As provided herein, an endorsable entity may be presented to an instant message user based upon parsing an instant message from an instant message conversation. An instant message may be parsed for a proper noun (e.g., a word or grouping of words within the instant message text). The proper noun (e.g., a retail product) may be compared to an index to determine a topic of interest (e.g., a manufacturer of the particular retail product). The topic of interest may be used to determined an endorsable entity (e.g., an advertisement of the manufacturer), which may be presented to instant message users engaged in the instant message conversation.

Abstract: Content may be effectively virally propagated using an arrangement that identifies prolific Internet users who are likely to share content more often and with more people. These users are termed “connectors” because they typically function as a common link between disparate groups and will thus be the center point of a large social graph. Connectors are valuable to identify because content that is received by them can be expected to propagate more quickly as compared with propagation by other users who are not connectors. Users of on-line applications (such as social networking applications) who have the greatest probability of being connectors are identified by the application of heuristics to data that pertains to the users.

Abstract: Usage data representing users' actions with applications, client devices such as PCs, and peripheral devices like personal media players is collected from a variety of sources and utilized by an automated user profile population service to pre-populate user profile forms with suggestions for entries that can be presented to an application user when initially registering with the application or when a user profile gets updated. The user can review the suggested pre-populated entries in the user profile form and accept those that are appropriate and desired and reject those that are not.

Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.

Abstract: Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.

Abstract: In accordance with the present invention, isolated nucleic acid encoding a host cell protein that regulates Tat transactivation has been discovered. The protein is the first discovered constituent of the TAK/TEFb complex which associates with the HIV Tat, via divalent cation metals, and is necessary for the binding of Tat to TAR RNA. This protein, cyclin T1, is an 87 kDa cyclin partner for the PITALRE kinase. It is further discovered that Tat must interact with TAK in order to bind to TAR RNA with affinity and with the appropriate sequence specificity that is observed in vivo. In accordance with another aspect of the invention, formulations useful for modulation of Tat transactivation have been developed. In addition, assays have been developed for the identification of compounds useful to modulate the above-described processes.

Abstract: In accordance with the present invention, a host cell protein has been discovered which regulates Tat transactivation. The protein is the first discovered constituent of the TAK/TEFb complex which associates with the HIV Tat, via divalent cation metals, and is necessary for the binding of Tat to TAR RNA. This protein, cyclin T1, is an 87 kDa cyclin partner for the PITALRE kinase. It is further discovered that Tat must interact with TAK in order to bind to TAR RNA with affinity and with the appropriate sequence specificity that is observed in vivo. In accordance with another aspect of the invention, formulations useful for modulation of Tat transactivation have been developed. In addition, assays have been developed for the identification of compounds useful to modulate the above-described processes.