Abstract: The present disclosure provides PROTAC compounds represented by Formula (A): D-L-DSM (A), or an enantiomer, a diastereoisomer, and/or a pharmaceutically acceptable salt of any one of the foregoing, wherein: DSM is a degradation signaling compound {e.g., an E3 ubiquitin ligase recruitment ligand, such as a CRBN ligand or a VHL ligand) covalently attached to a linker L; L is a linker that covalently attaches DSM to D; and D is a Bcl-xL inhibitor compound of Formula (I) or Formula (II) covalently attached to the linker L: (I); (II) wherein the definitions for the variables are described herein. Also provided are pharmaceutical compositions comprising the PROTAC compounds of the present disclosure and methods of use and methods of making thereof.

Abstract: Separator membranes for ion batteries and methods of producing such separator membranes are disclosed herein. The separator membranes have vertically-aligned pores that have as small as submicron diameters at one or both membrane surfaces. The separator membranes may be fabricated via a novel and innovative bidirectional freeze-casting process that produces a temperature gradient in two directions. The separator membranes disclosed herein and fabricated by this method can be used in ion batteries, such as sodium ion batteries.

Abstract: A computing device is configured to perform acts that include displaying a graphical user interface (GUI) of an operating system installed on the computing device, where a taskbar of the GUI includes a search box. The search box includes: 1) a text entry field that is configured to receive textual input; and 2) a graphical icon. The acts also include detecting a selection of the text entry field and presenting a first graphical pane on the display in response to detecting the selection of the text entry field, where the first graphical pane includes first content. The acts also include detecting a selection of the graphical icon. The acts further include presenting a second graphical pane on the display in response to detecting the selection of the graphical icon, where the second graphical pane comprises second content that is different from the first content.

Abstract: Techniques for limiting unwanted comments are described. For example, a social networking system may receive, from a first account of the social networking system, a request to post content. In some examples, the social networking system may further receive an instruction to limit an ability of certain accounts lacking a characteristic from commenting on the first account’s content. In some cases, the social networking system may receive, from a second account. Upon determining that the second account lacks the characteristic, the social networking system may refrain from sharing the comment with one or more additional users.

Abstract: Techniques for identifying a trigger associated with a recommendation to modify settings associated with a user account of a social networking system, and providing a recommendation to a user to review and/or modify the settings are described herein. The settings may include settings associated with other users commenting on data published by the user via the social networking system (e.g., posts published by the user), tagging or mentioning the user in a post, sending a direct message to the user, and/or the like. That is, the social networking system may be configured to identify a triggering event (e.g., trigger) associated with interactions with the user account, and to provide a recommendation for the user to review and/or modify one or more settings associated with the user account based on the interactions, such as to improve an overall user experience with the social networking system.

Abstract: The apparatus and methods of the present disclosure, in a broad aspect, provide novel ways for bonding or sealing pieces of glass of photovoltaic cell modules. These include providing the first piece of glass having a planar surface, providing the second piece of glass having a second planar surface, providing a photovoltaic cell between the first piece of glass and second piece of glass, providing an amount of solder to at least one solder contact area disposed on at least one of the first or second pieces of glass, bringing the first and second pieces of glass into contact at the at least one solder contact area, and heating the solder to about the melting point or working point of the solder to provide the first and second pieces of glass with a bond or seal at the at least one solder contact area.

Abstract: A new fiber optic cable splice for splicing optical fiber cables together and reconstructing fiber-optic cable that provide substantially enhanced reliability and broadened operating temperature range is disclosed. The disclosed cable splice offer reliable and user friendly solutions to applications in many harsh environments such as avionics, field vehicles, and defense related instrumentation. The cable splice consists of a preassembled one piece splice core and outer mechanical and thermal shielding layers. A simple splicing procedure and key fixtures are also disclosed.

Abstract: An fiber optic splice having provide substantially enhanced reliability and broadened operating temperature range uses a light-cured index matching fluid to splice the facing ends of the optical fibers in between two metallic tubes forming a leak-tight, thermally insulating, and mechanically robust outer package.