Abstract: A pharmaceutical composition comprises: a) 5 wt % to 95 wt % of a HCl salt of Compound (1).xH2O by the weight of the pharmaceutical composition, wherein x is from 0 to 3; and b) 5 wt % to 95 wt % of a filler by the weight of the pharmaceutical composition. Another pharmaceutical composition comprises: a) 1 mg/mL to 20 mg/mL of Compound (1) in water; and b) 0.01 M to 0.1 M of a pharmaceutically acceptable pH modifier. A method of preparing a pharmaceutical composition, comprising providing a mixture of Compound (1) that includes the HCl salt of Compound (1).xH2O and the filler. Another method of preparing a pharmaceutical composition comprises mixing the HCl salt of Compound (1).xH2O and the pH modifier to form 1 mg/mL to 20 mg/mL of Compound (1) in water. Methods of reducing the amount of influenza viruses, inhibiting the replication of influenza viruses, and treating influenza each independently employ such pharmaceutical compositions.

Abstract: A pharmaceutical composition comprises: a) 5 wt % to 95 wt % of a HCl salt of Compound (1).xH2O by the weight of the pharmaceutical composition, wherein x is from 0 to 3; and b) 5 wt % to 95 wt % of a filler by the weight of the pharmaceutical composition. Another pharmaceutical composition comprises: a) 1 mg/mL to 20 mg/mL of Compound (1) in water; and b) 0.01 M to 0.1 M of a pharmaceutically acceptable pH modifier. A method of preparing a pharmaceutical composition, comprising providing a mixture of Compound (1) that includes the HCl salt of Compound (1).xH2O and the filler. Another method of preparing a pharmaceutical composition comprises mixing the HCl salt of Compound-(1).xH2O and the pH modifier to form 1 mg/mL to 20 mg/mL of Compound (1) in water. Methods of reducing the amount of influenza viruses, inhibiting the replication of influenza viruses, and treating influenza each independently employ such pharmaceutical compositions.

Abstract: A pharmaceutical composition comprises: a) 5 wt % to 95 wt % of a HCl salt of Compound (1).xH2O by the weight of the pharmaceutical composition, wherein x is from 0 to 3; and b) 5 wt % to 95 wt % of a filler by the weight of the pharmaceutical composition. Another pharmaceutical composition comprises: a) 1 mg/mL to 20 mg/mL of Compound (1) in water; and b) 0.01 M to 0.1 M of a pharmaceutically acceptable pH modifier. A method of preparing a pharmaceutical composition, comprising providing a mixture of Compound (1) that includes the HCl salt of Compound (1).xH2O and the filler. Another method of preparing a pharmaceutical composition comprises mixing the HCl salt of Compound (1).xH2O and the pH modifier to form 1 mg/mL to 20 mg/mL of Compound (1) in water. Methods of reducing the amount of influenza viruses, inhibiting the replication of influenza viruses, and treating influenza each independently employ such pharmaceutical compositions.

Abstract: Methods and systems are provided for selectively displacing water from a hydraulically continuous water zone in a porous geological formation. The target zone to be displaced is defined by a hydrodynamically maintained pressure differential, which has been shown to be capable of confining an expanding injected gas zone. One or more gas injection wells and water production wells are located within the zone. During pressurized gas injection within the zone, the gas displaces water downward within the confined zone such that water is selectively produced from the target zone and the injected gas zone is confined within the hydraulically continuous water zone.

Abstract: A method and system for displacing water from a porous geological formation are provided. The zone to be displaced is defined by the injection of water into one or more barrier wells around the zone. One or more gas injection wells and water production wells are located within the zone. During pressurized gas injection within the zone, the barrier wells are operated to achieve a hydraulic pressure barrier surrounding the zone that is sufficient to prevent penetration therethrough by the injected gas. The well system is operated to concurrently limit gas entry into the water production well. Accordingly, the gas displaces water downward within the zone such that water is produced at the water production wells.

Abstract: Methods and systems are provided for selectively displacing water from a hydraulically continuous water zone in a porous geological formation. The target zone to be displaced is defined by a hydrodynamically maintained pressure differential, which has been shown to be capable of confining an expanding injected gas zone. One or more gas injection wells and water production wells are located within the zone. During pressurized gas injection within the zone, the gas displaces water downward within the confined zone such that water is selectively produced from the target zone and the injected gas zone is confined within the hydraulically continuous water zone.