Abstract: The present invention relates to genetically modified B cells and their uses thereof, for example, for the treatment of a variety of diseases and disorders, including cancer, heart disease, inflammatory disease, muscle wasting disease, neurological disease, and the like. In certain embodiments, the invention relates to an isolated modified B cell (“CAR-B cell), capable of expressing a chimeric receptor (“CAR-B receptor”), wherein said chimeric receptor comprises (a) an extracellular domain; (b) a transmembrane domain; and (c) a cytoplasmic domain that comprises at least one signaling domain. In various embodiments, the invention comprises an isolated modified B cell, wherein said B cell is capable of expressing and secreting a payload, wherein the payload is not naturally expressed in a B cell or is expressed at higher levels than is naturally expressed in a B cell. In various embodiments, the payload is an antibody or fragment thereof.

Abstract: The present invention is a waste container and comprises a hollow base, a drawer assembly, drawer receiver, laterally-slidable drawer, tray, pivot mechanism, and air freshener actuator. The drawer assembly and drawer receiver provide a mechanical means to push in and pull out the laterally-slidable drawer. The laterally-slidable drawer contains the tray responsible unto which waste is deposited. The pivot mechanism positions the tray horizontally and vertically for receiving waste and disposing of it in the base. Because the drawer assembly is separated from the hollow base the user is provided with two separate compartments, one for inserting waste and one for storing it. Also, the nuisance of coming into contact with harmful odors and bacteria in the base is eliminated. Furthermore, the air freshener actuator releases an air freshener into the base to prevent unwanted odors from permeating through the container.