Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: In some examples, a system includes a Universal Serial Bus (USB) interface to connect to a plurality of devices. The system includes a controller to receive battery information through the USB interface from the plurality of devices, wherein the battery information relates to batteries in respective devices of the plurality of devices, and control charging of the batteries through the USB interface using the battery information.

Abstract: Disclosed herein is an attachable pouch configured for use with protective clothing, such as a disposable protective medical clothing. The pouch includes a pouch portion and a back portion. The pouch portion includes a first side and a second side opposite the first side, and a bottom portion disposed between the first side and the second side. The first side, second side, and bottom portion define an opening. The pouch portion has a top edge and a bottom edge extending in a same direction as the top edge. A first flange extends outward from the first side and a second flange extends outward from the second side. The back portion includes a central portion and a peripheral portion surrounding the central portion. A first strap and a second strap are attached to the peripheral portion. The first flange and the second flange are attached to the peripheral portion.

Abstract: A physically stable skin care composition with a continuous phase and a dispersed phase and a method for making the same. The continuous phase can include from about 0.5% to about 1.5% sodium hyaluronate with a weight average molecular weight from about 500,000 to about 1,000,000 Da according to the European Pharmacopoeia Method. The continuous phase can also include at least two thickening agents that can includes polyacrylamide polymers and copolymers and a carboxylic acid polymer. The dispersed phase can include silicone. The composition can have an average viscosity greater than 25,000 cP and the sodium hyaluronate can be fully hydrated.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for closed-loop sleep protection and/or sleep regulation. According to an aspect, sleep disturbing noises are predicted and a biosignal parameter is measured to dynamically mask predicted disturbing environmental noises in the sleeping environment with active attenuation. Environmental noises in a sleeping environment of a subject are detected, input, or predicted based on historical data of the sleeping environment collected over a period of time. The biosignal parameter is used to determine sleep physiology of a subject. Based on the environmental noises in the sleeping environment and the determined sleep physiology, the noises are predicted to be disturbing or non-disturbing noises. For predicted disturbing noises, one or more actions are taken to regulate sleep and avoid sleep disruption by using sound masking prior to or concurrently with the occurrence of the predicted disturbing noises.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for non-linear breathing entrainment. As described herein, “breathing entrainment” refers to guiding a user's breath or breathing. According to an aspect, an initial breathing period and a final breathing period are selected. Based on the initial and final breathing periods, a non-linear breath rate per minute sequence is determined. A guiding stimulus is output and aligned with the non-linear breath rate per minute sequence. The guiding stimulus is non-linearly altered with the non-linear breath rate per minute sequence to align with the final breathing period over an interval of time. The non-linear alterations of the guiding stimulus vary based on an amount of time the guiding stimulus has been output.

Abstract: A basket strainer insert having a body with one or more magnets disposed therein. The basket strainer insert includes a baffle to disrupt the flow of liquid through the basket strainer and facilitates the attraction of metallic particles to the body. The baffle has a plurality of lobes secured to the body with connection portions and separated from each other by gaps. The lobes may have an inward bend, an outward bend, or may be planar.

Abstract: There is a need for solutions that monitor memory loss with reduced caretaker involvement. This need can be addressed by, for example, selecting a first question from a group of multiple questions to ask a user of a computing device based one or more attributes associated with each question in the group of multiple questions; receiving a first answer by the user of the computing device to the first question; determining, from the first answer, one or more behavioral attributes associated with user response to the first question; and determining, based on the one or more behavioral attributes, a cognitive capability of the user of the computing device.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for non-linearly decreasing an auditory experience output. According to an aspect, a non-linear decreasing rate is applied to an audio output of the auditory experience. The non-linear decreasing rate varies as a function of decibel amplitude over time in seconds. The non-linear decreasing rate comprises a plurality of segments connected together. The audio of the guided breathing is output at the non-linear decreasing rate until a decibel level of the audio output is below one of a decibel level of ambient noises in a user's environment or a predetermined decibel level.

Abstract: In at least some aspects, the present concepts include a method for configuring an assistive flexible suit including the acts of outfitting a person with an assistive flexible suit, monitoring an output of at least one sensor of the assistive flexible suit as the person moves in a first controlled movement environment, identifying at least one predefined gait event using the output of the at least one sensor, adjusting an actuation profile of the at least one actuator and continuing to perform the acts of monitoring, identifying and adjusting until an actuation profile of the at least one actuator generates a beneficial moment about the at least one joint to promote an improvement in gait. The at least one controller is then set to implement the actuation profile.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for a personalized wake-up system. A sleep assistance device outputs a sound. In response to detecting a sound that exhibits one or more predetermined sound properties, actions are taken to adjusting the sound in an effort to wake the subject. Examples of predetermined sound properties include any sound detected over a threshold decibel level, sounds detected at a certain frequency spectrum. According to aspects, subject may further configure the system to alert the subject based on a set of personalized sounds the subjects considers to be important. According to aspects, the audio device or system is configured to determine the subject is awake based on collected biosignal parameters. The audio device or system takes further actions to disrupt the subject's sleep until the subject is determined to be awake.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for non-linear breathing entrainment. According to an aspect, a final breathing period is selected, and a current breathing period of a user is measured. A guiding stimulus configured to alter the current breathing period towards the final breathing period over an interval of time at a non-linear prescribed rate is output. A difference between the current breathing period and a target breathing period along the non-linear linear prescribed rate is determined. Based at least in part on the difference, the guiding stimulus and/or the non-linear prescribed rate are adjusted. The guiding stimulus and the non-linear prescribed rate may be stabilized, increased, or decreased to enable the user to reach the final breathing period.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for dynamically adjusting a breathing entrainment based on whether a user is stressing or relaxing. According to an aspect, a first target breathing period is selected, and a guiding stimulus configured to alter a current breathing period of the user towards the first target breathing period over an interval of time is output. One or more relaxation biometrics are measured and analyzed to determine whether the user is stressing or relaxing. Based on whether the user is relaxing or stressing, at least one of the guided stimulus and the first target breathing period are adjusted, where the first target breathing period is adjusted to a second target breathing period different from the first target breathing period. By making adjustments based on whether a user is relaxing or stressing, the breathing entrainment is more effective and comfortable for users.

Abstract: A basket strainer insert having a body with one or more magnets disposed therein. The basket strainer insert includes a baffle that is removable. The movement of withdrawing the baffle from the body allows magnetic debris to be removed. A baffle may be disposed at the center of the elongate intermediate portion of the body. The baffle may comprise a collar and two or more symmetrical lobes, each lobe comprising an upper portion and a lower portion. Alternatively, the baffle may be a hollow shape with a plurality of apertures.

Abstract: A basket strainer insert having a body with one or more magnets disposed therein. The basket strainer insert includes a baffle that is removable. The movement of withdrawing the baffle from the body allows magnetic debris to be removed. A baffle may be disposed at the center of the elongate intermediate portion of the body. The baffle may comprise a collar and two or more symmetrical lobes, each lobe comprising an upper portion and a lower portion. Alternatively, the baffle may be a hollow shape with a plurality of apertures.

Abstract: A basket strainer insert having a body with one or more magnets disposed therein. The basket strainer insert includes a baffle to disrupt the flow of liquid through the basket strainer and facilitates the attraction of metallic particles to the body. The baffle has a plurality of lobes secured to the body with connection portions and separated from each other by gaps. The lobes may have an inward bend, an outward bend, or may be planar.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for dynamic starting rates for guided breathing. According to an aspect, a user's initial breathing metric is determined. A multiplier is then determined, where the multiplier varies as a function of the initial breathing metric within a range. The level of intensity of the multiplier may vary, and may be a dynamic feature based on the determination of the user's initial breathing metric. Once the multiplier is determined, the multiplier is applied to the user's initial breathing metric to determine a starting breathing metric for guided breathing. The starting breathing metric is slower than or equal to the user's initial breathing metric.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for closed-loop sleep protection and/or sleep regulation. According to an aspect, sleep disturbing noises are predicted and a biosignal parameter is measured to dynamically mask predicted disturbing environmental noises in the sleeping environment with active attenuation. Environmental noises in a sleeping environment of a subject are detected, input, or predicted based on historical data of the sleeping environment collected over a period of time. The biosignal parameter is used to determine sleep physiology of a subject. Based on the environmental noises in the sleeping environment and the determined sleep physiology, the noises are predicted to be disturbing or non-disturbing noises. For predicted disturbing noises, one or more actions are taken to regulate sleep and avoid sleep disruption by using sound masking prior to or concurrently with the occurrence of the predicted disturbing noises.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for dynamically masking audible breathing noises determined to be generated by one or more sleeping partners. According to aspects, a subject's sleep is protected by detecting audible breathing noises in a sleeping environment, determining the audible breathing noises are not generated by the subject, and mitigating the perception of the audible breathing noises that are determined to originate from another subject, such as a bed partner, pet, etc. The dynamic masking reduces the subject's exposure to unnecessary sounds and reduces the chances of masking sounds disturbing the subject's sleep.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for closed-loop sleep protection and/or sleep regulation. According to an aspect, sleep disturbing noises are predicted and a biosignal parameter is measured to dynamically mask predicted disturbing environmental noises in the sleeping environment with active attenuation. Environmental noises in a sleeping environment of a subject are detected, input, or predicted based on historical data of the sleeping environment collected over a period of time. The biosignal parameter is used to determine sleep physiology of a subject. Based on the environmental noises in the sleeping environment and the determined sleep physiology, the noises are predicted to be disturbing or non-disturbing noises. For predicted disturbing noises, one or more actions are taken to regulate sleep and avoid sleep disruption by using sound masking prior to or concurrently with the occurrence of the predicted disturbing noises.