Abstract: A method of generating and displaying quantitative T1-weighted subtraction images or maps, also known as delta T1 maps, using a “FLOW” (red/blue) color look up table (CLUT) automatically without additional processing steps or manual intervention, The delta T1 weighted maps display objective visualization via red image enhancement and spatial visualization of underlying anatomy via computational generation of small values of ‘blue’ non-enhancing regions.

Abstract: A magnetic resonance imaging (MRI) methodology is provided for simultaneous measurement of dynamic susceptibility contrast (DSC) MRI and dynamic contrast enhanced (DCE) MRI perfusion and permeability parameters using a combination of dual echo and spiral acquisition techniques with no contrast agent preload. T1 and T2/T2* leakage effects are eliminated, thereby permitting accurate measurement of blood volume, blood flow and vascular permeability which are used in evaluating tumor angiogenesis.

Abstract: An improved method for detecting tumor cell invasion using diffusion times as short as two (2) msec incorporates diffusion weighing imaging techniques into a standard spin echo (SE) pulse sequence to minimize the effects of compartment boundary restrictions on diffusion values and corresponding MRI imaging data related to glioma invasion.

Abstract: A magnetic resonance imaging (MRI) methodology is provided for simultaneous measurement of dynamic susceptibility contrast (DSC) MRI and dynamic contrast enhanced (DCE) MRI perfusion and permeability parameters using a combination of dual echo and spiral acquisition techniques with no contrast agent preload. T1 and T2/T2* leakage effects are eliminated, thereby permitting accurate measurement of blood volume, blood flow and vascular permeability which are used in evaluating tumor angiogenesis.

Abstract: One or two sets of time course NMR data are acquired using an EPI pulse sequence in which either or both gradient recalled echo NMR signals and spin-echo NMR signals are acquired after bolus injection of a contrast agent. T2* relaxation rates for GE and T2 relaxation rates for SE are calculated from the acquired NMR signals and are corrected for extravasation of contrast agent into surrounding tissues. The gradient-echo signals and spin-echo NMR signals are employed along with the T2* and T2 relaxation rates to calculate hemodynamic parameter maps which are used as a measure of tumor angiogenesis.

Abstract: An interactive display interface may import fMRI images, DTI images, MRS images and perfusion images of the brain and selectively display them on top of one another and aligned with an anatomical image of the brain. The transparency of each layered image can be adjusted or turned on or off to assist in the planning of a treatment strategy for a brain tumor or other diseased region in the brain.