Patents by Inventor Katsuhiko Miyasaka
Katsuhiko Miyasaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5221674Abstract: A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom,or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.Type: GrantFiled: September 27, 1991Date of Patent: June 22, 1993Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Kikuo Yasuda, Kenyu Shibata, Nobuyoshi Minami, Toshimi Seki, Masafumi Shiraiwa, Tomio Nakao, Katsuhiko Miyasaka, Tsutomu Ishimori, Kotaro Gotanda, Takako Sasaki
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Patent number: 5130314Abstract: A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom,or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.Type: GrantFiled: September 27, 1991Date of Patent: July 14, 1992Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Kikuo Yasuda, Kenyu Shibata, Nobuyoshi Minami, Toshimi Seki, Masafumi Shiraiwa, Tomio Nakao, Katsuhiko Miyasaka, Tsutomu Ishimori, Kotaro Gotanda, Takako Sasaki
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Patent number: 5082844Abstract: A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an asymmetric carbon atom, or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.Type: GrantFiled: June 18, 1990Date of Patent: January 21, 1992Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Kikuo Yasuda, Kenyu Shibata, Nobuyoshi Minami, Toshimi Seki, Masafumi Shiraiwa, Tomio Nakao, Katsuhiko Miyasaka, Tsutomu Ishimori, Kotaro Gotanda, Takako Sasaki
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Patent number: 4910216Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a methoxy group, and A is a C.sub.1 -C.sub.4 alkylene group, or a pharmaceutically acceptable salt thereof. This compound is useful as a medicine, particularly as a lipoxygenase inhibitor for polyunsaturated fatty acids.Type: GrantFiled: February 25, 1988Date of Patent: March 20, 1990Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Yasushi Suzuki, Yukio Hasegawa, Michitaka Sato, Morinobu Saito, Norio Yamamoto, Katsuhiko Miyasaka, Takashi Mikami, Katsuhiko Miyazawa
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Patent number: 4695581Abstract: A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group; each of R.sub.2 and R.sub.3 represents an alkyl group having 1 to 3 carbon atoms; and each of R.sub.4, R.sub.5 and R.sub.6 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, an aralkyloxy group, a lower alkylthio group, a lower haloalkyl group, a hydroxyl group, a cyano group, a nitro group, an amino group, a mono- or di-(lower alkyl or aralkyl)amino group or a group of the formula ##STR2## in which R.sub.7 represents a lower alkylene group having at least 2 carbon atoms, one of R.sub.8 and R.sub.9 represents a hydrogen atom or a lower alkyl group and the other represents a lower alkyl group, and R.sub.10 represents a hydrogen atom or a lower alkyl group; or any two of R.sub.4, R.sub.5 and R.sub.6 which are adjacent to each other, together, represent a lower alkylenedioxy group, and a salt thereof; and a process for production thereof.Type: GrantFiled: August 29, 1985Date of Patent: September 22, 1987Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Yasushi Suzuki, Yukio Hasegawa, Michitaka Sato, Morinobu Saito, Norio Yamamoto, Katsuhiko Miyasaka, Takashi Mikami, Katsuhiko Miyazawa
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Patent number: 4673692Abstract: A compound represented by the formula ##STR1## wherein R.sup.1 represents a hydroxyl group, an alkanoyloxy group or a group of the formula ##STR2## in which R.sup.2 represents a hydrogen atom or a lower alkyl group, and R.sup.3 represents a hydrogen atom, a lower alkyl group, an alkanoyl group, a phenyl group, a carbamoyl group or a thiocarbamoyl group, or a salt thereof.The said compound can be prepared by reacting a compound represented by the formula ##STR3## with a compound of the formulaNH.sub.2 --R.sup.1 (III)wherein R.sup.1 is as defined hereinabove, or a salt thereof, and as required, alkanoylating the resulting compound of formula (I) in which R.sup.1 represents a hydroxyl group or an amino group, and as required, converting the resulting compound of formula (I) in which R.sup.1 is the group ##STR4## into its salt, and is useful for the treatment of inflammation, pain or rheumatism.Type: GrantFiled: October 18, 1985Date of Patent: June 16, 1987Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Yasushi Suzuki, Yukio Hasegawa, Michitaka Sato, Morinobu Saito, Norio Yamamoto, Katsuhiko Miyasaka, Takashi Mikami, Katsuhiko Miyazawa
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Patent number: 4337256Abstract: Novel isoquinoline derivatives of the general formula ##STR1## wherein R represents a lower alkyl group, a lower cycloalkyl group, or a group of the formula ##STR2##in which R.sup.2 represents a hydrogen atom, a halogen atom, a methyl group, a trifluoromethyl group, a methoxy group, a methylamino group or a dimethylami no group;R.sup.1 represents a hydrogen atom or a lower alkyl group; andY represents a carboxyl group, a cyano group, a carbamoyl group, a lower alkoxycarbonyl group or a lower alkylaminocarbonyl group;or a salt thereof; a process for the production thereof.The above compound is useful as an anti-inflammatory and analgesic agent.Type: GrantFiled: December 27, 1979Date of Patent: June 29, 1982Assignee: Teikoku Hormone Manufacturing Co., Ltd.Inventors: Yasushi Suzuki, Kunio Tsukamoto, Nobuyoshi Minami, Yukio Hasegawa, Michitaka Satoh, Norio Yamamoto, Katsuhiko Miyasaka, Takashi Mikami, Satoshi Funakoshi
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Patent number: 4230703Abstract: Compounds of the general formula ##STR1## or their salts, esters or amide derivatives; and processes for their preparation. In the formula, R.sub.O represents hydrogen or lower alkyl, R.sub.2 represents hydrogen, halogen or nitro, R.sub.3 represents hydrogen or halogen, and R.sub.4 represents hydrogen or lower alkyl; and when R.sub.O is hydrogen, R.sub.2, R.sub.3 and R.sub.4 are all hydrogens and the group ##STR2## is present at the 2-position. These compounds exhibit superior analgesic and/or anti-inflammatory actions with little gastrointestinal troubles.Type: GrantFiled: March 28, 1978Date of Patent: October 28, 1980Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Yasushi Suzuki, Kunio Tsukamoto, Nobuyoshi Minami, Yukio Hasegawa, Tadaharu Watanabe, Katsuhiko Miyasaka, Takashi Mikami, Satoshi Funakoshi