Abstract: A method of extracting information from a flowchart image comprising a plurality of closed-shaped data nodes having text enclosed within, connecting lines connecting the plurality of closed-shaped data nodes and free text adjacent to the connecting lines includes receiving the flowchart image, detecting the closed-shaped data nodes, localizing the text enclosed within the closed-shaped data nodes, and masking the localized text.to generate an annotated image. Lines in the annotated image are the detected to reconstruct them as closed-shaped data nodes and connecting lines. A tree frame with the plurality of closed-shaped data nodes and the connecting lines is extracted. The free text is then localized. Chunks of the free text oriented and positioned proximally together are assembled into text blocks using an orientation-based two-dimensional clustering.

Abstract: A method of extracting information from a flowchart image comprising a plurality of closed-shaped data nodes having text enclosed within, connecting lines connecting the plurality of closed-shaped data nodes and free text adjacent to the connecting lines includes receiving the flowchart image, detecting the closed-shaped data nodes, localizing the text enclosed within the closed-shaped data nodes, and masking the localized text.to generate an annotated image. Lines in the annotated image are the detected to reconstruct them as closed-shaped data nodes and connecting lines. A tree frame with the plurality of closed-shaped data nodes and the connecting lines is extracted. The free text is then localized. Chunks of the free text oriented and positioned proximally together are assembled into text blocks using an orientation-based two-dimensional clustering.

Abstract: A method of extracting information from a flowchart image comprising a plurality of closed-shaped data nodes having text enclosed within, connecting lines connecting the plurality of closed-shaped data nodes and free text adjacent to the connecting lines includes receiving the flowchart image, detecting the closed-shaped data nodes, localizing the text enclosed within the closed-shaped data nodes, and masking the localized text.to generate an annotated image. Lines in the annotated image are the detected to reconstruct them as closed-shaped data nodes and connecting lines. A tree frame with the plurality of closed-shaped data nodes and the connecting lines is extracted. The free text is then localized. Chunks of the free text oriented and positioned proximally together are assembled into text blocks using an orientation-based two-dimensional clustering.

Abstract: A method of extracting information from a flowchart image comprising a plurality of closed-shaped data nodes having text enclosed within, connecting lines connecting the plurality of closed-shaped data nodes and free text adjacent to the connecting lines includes receiving the flowchart image, detecting the closed-shaped data nodes, localizing the text enclosed within the closed-shaped data nodes, and masking the localized text.to generate an annotated image. Lines in the annotated image are the detected to reconstruct them as closed-shaped data nodes and connecting lines. A tree frame with the plurality of closed-shaped data nodes and the connecting lines is extracted. The free text is then localized. Chunks of the free text oriented and positioned proximally together are assembled into text blocks using an orientation-based two-dimensional clustering.

Abstract: This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung c

Abstract: This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung c

Abstract: This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung c

Abstract: The present invention provides for the first time a quantum mechanics-based method for scoring protein-ligand interactions and binding affinity predictions, using quantum mechanical Hamiltonians and/or a combined quantum mechanical/molecular mechanical approach, and Poisson-Boltzmann (PB)-based solvation methods. Also provided is a method for using quantum mechanics to describe the enthalpic and solvation effects of binding. The method comprises comparing the calculated binding affinities to experimental values in order to measure the success of the method. The methods disclosed herein may further be used to score protein and drug or protein and inhibitor interactions. The present method can predict the free energy of binding of protein-ligand complexes with high accuracy so as to enable lead optimization, thus serving as a powerful tool in computational drug design.