Abstract: A tissue sample analysis device 1 that quantitatively analyzes photometric information obtained by applying light to a tissue sample M of a living body, the tissue sample analysis device including: a light source unit 30 that applies the light to the tissue sample M; and a flat light receiving unit 31 that is disposed opposite to the light source unit 30, and in a state in which the tissue sample M is disposed between the light source unit 30 and the light receiving unit 31 itself, receives light transmitted through the tissue sample M or light radiated from the tissue sample M.

Abstract: A tissue sample analysis device 1 that quantitatively analyzes photometric information obtained by applying light to a tissue sample M of a living body, the tissue sample analysis device including: a light source unit 30 that applies the light to the tissue sample M; and a flat light receiving unit 31 that is disposed opposite to the light source unit 30, and in a state in which the tissue sample M is disposed between the light source unit 30 and the light receiving unit 31 itself, receives light transmitted through the tissue sample M or light radiated from the tissue sample M.

Abstract: L-glutamine is produced by culturing a coryneform bacterium having L-glutamine-producing ability and modified so that intracellular glutaminase activity is reduced, and preferably also modified so that intracellular glutamine synthetase activity is enhanced. The method of production includes culturing the bacterium in a medium, followed by accumulation of L-glutamine in the medium and collecting the L-glutamine from the medium.

Abstract: Succinic acid is produced by using a coryneform bacterium which has succinic acid-producing ability and has been modified so that an activity of pyruvate oxidase is decreased.

Abstract: L-glutamine is produced by culturing a coryneform bacterium having L-glutamine-producing ability and modified so that intracellular glutaminase activity is reduced, and preferably also modified so that intracellular glutamine synthetase activity is enhanced. The method of production includes culturing the bacterium in a medium, followed by accumulation of L-glutamine in the medium and collecting the L-glutamine from the medium.

Abstract: A plurality of immunofluorescent reactions on the same brain specimen is analyzed and imaged correlatively at the cellular level. Information at a plurality of points on a tissue sample 9 is measured using a photometer 7 while two-dimensionally moving a scanning stage 5 on which the tissue sample 9 is placed. The measured signals are input to a memory 29 and stored therein, and a tissue map is created by obtaining two-dimensional information for the sample 9 from the memory 29. After reacting a reagent A′ specific to a substance A with the tissue sample to be mapped, a distribution image of the reaction areas of the reagent A′ is created by scanning the sample in the two-dimensional directions, and, after reacting a reagent B′ specific to a substance B with the same sample, a distribution image of the reaction areas of the reagent B′ is created by scanning the sample in the two-dimensional directions.