Patents by Inventor Kazimierz Nowaczyk

Kazimierz Nowaczyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METAL-ENHANCED FLUORESCENCE FOR THE LABEL-FREE DETECTION OF INTERACTING BIOMOLECULES
    Publication number: 20100035335
    Abstract: A method for enhancing fluorescence of a biomolecule includes the step of associating the biomolecule having intrinsic fluorescence with a sensing surface that contains nanostructured metal. Association of the biomolecule with the nanostructured metal enhances its intrinsic fluorescence, which is detected upon exposure to electromagnetic radiation of a suitable wavelength. The sensing surface may include capture or ligand molecule which binds to the biomolecule and sequesters it in proximity to the nanostructured metal, thereby causing its fluorescent signal to be enhanced. The method can be used in label-free bioassays for detection of interacting biomolecules, such as antibody-antigen binding.
    Type: Application
    Filed: August 7, 2009
    Publication date: February 11, 2010
    Inventors: Joseph R. Lakowicz, Henryk Szmacinski, Krishanu Ray, Mustafa Habib Chowdhury, Kazimierz Nowaczyk
  • Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
    Patent number: 5485530
    Abstract: A method and apparatus for detection and/or measurement of physical characteristics of a sample based on multi-dimensional phase-modulation fluorescence lifetime imaging using at least one fluorescent probe having known and/or variable fluorescent lifetimes.
    Type: Grant
    Filed: July 23, 1993
    Date of Patent: January 16, 1996
    Assignee: Joseph R. Lakowicz
    Inventors: Joseph R. Lakowicz, Klaus W. Berndt, Kazimierz Nowaczyk, Henryk Szmacinski, Michael L. Johnson