Patents by Inventor Kazuhide Hayakawa
Kazuhide Hayakawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220380362Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.Type: ApplicationFiled: December 8, 2021Publication date: December 1, 2022Applicant: Japan Tobacco Inc.Inventors: Hisashi KAWASAKI, Hiroyuki ABE, Kazuhide HAYAKAWA, Tetsuya IIDA, Shinichi KIKUCHI, Takayuki YAMAGUCHI, Toyomichi NANAYAMA, Hironori KURACHI, Masahiro TAMARU, Yoshikazu HORI, Mitsuru TAKAHASHI, Takayuki YOSHIDA, Toshiyuki SAKAI
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Patent number: 11338388Abstract: Disclosed is a laser keyhole welding structure and a keyhole welding method of an aluminum material which stably suppress the generation of sputtering to ensure a reliable electrical connection and obtain a mechanically strong connection. To achieve this, a laser keyhole welding structure of an aluminum material is formed by welding an aluminum material element constituting an electronic component by irradiating a laser beam to the electronic component, in which a tapered portion spread angle (?) of an upper portion of a welding nugget to be formed is 45° or less. Also disclosed is a laser keyhole welding structure of an aluminum material.Type: GrantFiled: March 29, 2018Date of Patent: May 24, 2022Assignee: NIPPON CHEMI-CON CORPORATIONInventors: Kazuhide Hayakawa, Fumito Odashima, Tatsuo Kubouchi
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Publication number: 20200109139Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.Type: ApplicationFiled: May 20, 2019Publication date: April 9, 2020Applicant: Japan Tobacco Inc.Inventors: Hisashi KAWASAKI, Hiroyuki ABE, Kazuhide HAYAKAWA, Tetsuya IIDA, Shinichi KIKUCHI, Takayuki YAMAGUCHI, Toyomichi NANAYAMA, Hironori KURACHI, Masahiro TAMARU, Yoshikazu HORI, Mitsuru TAKAHASHI, Takayuki YOSHIDA, Toshiyuki SAKAI
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Publication number: 20200047282Abstract: Disclosed is a laser keyhole welding structure and a keyhole welding method of an aluminum material which stably suppress the generation of sputtering to ensure a reliable electrical connection and obtain a mechanically strong connection. To achieve this, a laser keyhole welding structure of an aluminum material is formed by welding an aluminum material element constituting an electronic component by irradiating a laser beam to the electronic component, in which a tapered portion spread angle (?) of an upper portion of a welding nugget to be formed is 45° or less. Also disclosed is a laser keyhole welding structure of an aluminum material.Type: ApplicationFiled: March 29, 2018Publication date: February 13, 2020Inventors: Kazuhide HAYAKAWA, Fumito ODASHIMA, Tatsuo KUBOUCHI
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Publication number: 20180273531Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.Type: ApplicationFiled: October 27, 2017Publication date: September 27, 2018Applicant: Japan Tobacco Inc.Inventors: Hisashi KAWASAKI, Hiroyuki ABE, Kazuhide HAYAKAWA, Tetsuya IIDA, Shinichi KIKUCHI, Takayuki YAMAGUCHI, Toyomichi NANAYAMA, Hironori KURACHI, Masahiro TAMARU, Yoshikazu HORI, Mitsuru TAKAHASHI, Takayuki YOSHIDA, Toshiyuki SAKAI
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Publication number: 20170029418Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.Type: ApplicationFiled: February 24, 2016Publication date: February 2, 2017Applicant: Japan Tobacco Inc.Inventors: Hisashi KAWASAKI, Hiroyuki ABE, Kazuhide HAYAKAWA, Tetsuya IIDA, Shinichi KIKUCHI, Takayuki YAMAGUCHI, Toyomichi NANAYAMA, Hironori KURACHI, Masahiro TAMARU, Yoshikazu HORI, Mitsuru TAKAHASHI, Takayuki YOSHIDA, Toshiyuki SAKAI
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Publication number: 20150183812Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.Type: ApplicationFiled: August 7, 2014Publication date: July 2, 2015Inventors: Hisashi KAWASAKI, Hiroyuki ABE, Kazuhide HAYAKAWA, Tetsuya IIDA, Shinichi KIKUCHI, Takayuki YAMAGUCHI, Toyomichi NANAYAMA, Hironori KURACHI, Masahiro TAMARU, Yoshikazu HORI, Mitsuru TAKAHASHI, Takayuki YOSHIDA, Toshiyuki SAKAI
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Patent number: 8835443Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.Type: GrantFiled: November 25, 2009Date of Patent: September 16, 2014Assignee: Japan Tobacco Inc.Inventors: Hisashi Kawasaki, Hiroyuki Abe, Kazuhide Hayakawa, Tetsuya Iida, Shinichi Kikuchi, Takayuki Yamaguchi, Toyomichi Nanayama, Hironori Kurachi, Masahiro Tamaru, Yoshikazu Hori, Mitsuru Takahashi, Takayuki Yoshida, Toshiyuki Sakai
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Publication number: 20100240613Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.Type: ApplicationFiled: November 25, 2009Publication date: September 23, 2010Applicant: Japan Tobacco Inc.Inventors: Hisashi Kawasaki, Hiroyuki Abe, Kazuhide Hayakawa, Tetsuya Iida, Shinichi Kikuchi, Takayuki Yamaguchi, Toyomichi Nanayama, Hironori Kurachi, Masahiro Tamaru, Yoshikazu Hori, Mitsuru Takahashi, Takayuki Yoshida, Toshiyuki Sakai
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Publication number: 20080312228Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.Type: ApplicationFiled: March 21, 2008Publication date: December 18, 2008Applicant: Japan Tobacco Inc.Inventors: Hisashi Kawasaki, Hiroyuki Abe, Kazuhide Hayakawa, Tetsuya Iida, Shinichi Kikuchi, Takayuki Yamaguchi, Toyomichi Nanayama, Hironori Kurachi, Masahiro Tamaru, Yoshikazu Hori, Mitsuru Takahashi, Takayuki Yoshida, Toshiyuki Sakai
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Patent number: 7378423Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.Type: GrantFiled: June 10, 2005Date of Patent: May 27, 2008Assignee: Japan Tobacco Inc.Inventors: Hisashi Kawasaki, Hiroyuki Abe, Kazuhide Hayakawa, Tetsuya Iida, Shinichi Kikuchi, Takayuki Yamaguchi, Toyomichi Nanayama, Hironori Kurachi, Masahiro Tamaru, Yoshikazu Hori, Mitsuru Takahashi, Takayuki Yoshida, Toshiyuki Sakai
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Publication number: 20060014768Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.Type: ApplicationFiled: June 10, 2005Publication date: January 19, 2006Applicant: Japan Tobacco Inc.Inventors: Hisashi Kawasaki, Hiroyuki Abe, Kazuhide Hayakawa, Tetsuya Iida, Shinichi Kikuchi, Takayuki Yamaguchi, Toyomichi Nanayama, Hironori Kurachi, Masahiro Tamaru, Yoshikazu Hori, Mitsuru Takahashi, Takayuki Yoshida, Toshiyuki Sakai
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Patent number: 5332734Abstract: Disclosed is a novel oxazinone derivative represented by formula (I) given below or a pharmaceutically acceptable acid-addition salt thereof, which is useful as an anti-inflammatory agent, an agent for suppressing neutrophil infiltration and as a serine protease inhibitor: ##STR1## where A includes, for example, ##STR2## in which W is --O--, --S--, --CH.dbd.CH-- or --NR.sup.9 -- or means that (CH.sub.2).sub.n is directly bonded to (CH.sub.2).sub.n,V.sup.2 is .dbd.CR.sup.12 -- or .dbd.N--, andD is 5 to 7-membered carbon ring or hetero ring;X is --O--, --S--, --CO--, or --NR.sup.15 or means that A is directly bonded to (CH.sub.2).sub.l ;Y is --O--, --CH.dbd.CH-- or --NR.sup.16 -- or means that (CH.sub.2).sub.l is directly bonded to Z;Z is --CH.sub.2 -- or --CO--; andl is an integer of 0 to 4.Further, R and R.sup.1 to R.sup.16 are hydrogen atom, lower alkyl group, etc.Type: GrantFiled: December 10, 1992Date of Patent: July 26, 1994Assignee: Japan Tobacco, IncorporatedInventors: Koji Kobayashi, Shunichi Manabe, Yoshihiro Watanabe, Kazuhide Hayakawa, Itsuo Uchida