Abstract: A method of treating wastewater containing an organic compound includes feeding wastewater to an anoxic tank, adding compounds containing nitrogen and phosphorus components to wastewater, performing anaerobic treatment on wastewater, and discharging treated wastewater as pre-treated water; introducing pre-treated water into an anaerobic treatment tank, performing anaerobic treatment on pre-treated water, thereby decomposing the organic compound into organic compounds of smaller molecular size and a mixture gas containing methane and carbon dioxide, and discharging treated water as primary water; introducing primary water into an aerobic treatment tank, performing aerobic treatment on primary water, and discharging treated water through a solid-liquid separator as secondary water; and introducing at least a part of secondary water into a reverse osmosis membrane separation unit, and separating part of secondary water into RO permeated water and RO concentrated brine, wherein at least a part of RO concentrated