Patents by Inventor Kazuhiko Kuwahara
Kazuhiko Kuwahara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7667006Abstract: The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.0×10?9 (M) or less; a pharmaceutical composition comprising the antibody or fragment thereof; and a method of producing an anti-HIV antibody or a fragment thereof, comprising immunizing a GANP transgenic non-human mammal or a progeny thereof with a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO: 6 as an antigen and collecting the antibody from the resultant mammal or progeny.Type: GrantFiled: March 9, 2004Date of Patent: February 23, 2010Assignee: Kumamoto Technology and Industry FoundationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara, Chiemi Minoda
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Publication number: 20080050365Abstract: The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12 glycoprotein of HIV and has a dissociation constant (KD) value of 1.Type: ApplicationFiled: March 9, 2004Publication date: February 28, 2008Applicant: Kumamoto Technology and Industry FoundationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara, Chiemi Minoda
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Patent number: 7138509Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.Type: GrantFiled: October 12, 2004Date of Patent: November 21, 2006Assignee: Kumamoto Technology & Industry FoundationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Publication number: 20060057695Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.Type: ApplicationFiled: October 12, 2004Publication date: March 16, 2006Applicant: KUMAMOTO TECHNOLOGY & INDUSTRY FOUNDATIONInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Publication number: 20060040372Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the arnino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.Type: ApplicationFiled: July 13, 2005Publication date: February 23, 2006Applicant: IMMUNOKICK INCORPORATIONInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Patent number: 6943237Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.Type: GrantFiled: December 30, 2003Date of Patent: September 13, 2005Assignee: Immunokick IncorporationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Patent number: 6825020Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.Type: GrantFiled: August 12, 2003Date of Patent: November 30, 2004Assignee: Kumamoto Technology & Industry FoundationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Publication number: 20040229309Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes said protein.Type: ApplicationFiled: December 30, 2003Publication date: November 18, 2004Applicant: KUMAMOTO TECHNOLOGY & INDUSTRY FOUNDATIONInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Patent number: 6673913Abstract: The object of the present invention is to provide a novel protein having a kinase activity and a gene encoding said protein. According to the present invention, there is provided a GANP protein which is represented by the amino acid sequence shown in SEQ ID No. 1 or No. 3 of the sequence listing, and is involved in the signal conversion of abnormal B cell differentiation in an autoimmune state, and has a kinase activity, and a polynucleotide which encodes the protein.Type: GrantFiled: December 5, 2001Date of Patent: January 6, 2004Assignee: Kumamoto Technology & Industry FoundationInventors: Nobuo Sakaguchi, Kazuhiko Kuwahara
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Patent number: 5597037Abstract: An object of the present invention is to minimize a volume of a hollow body by a combination of a horizontal H-letter shaped type gas-liquid separator and a plurality of plate-fin heat exchangers having a larger heat exchange performance per volume. In the present heat exchanging apparatus, fluid and refrigerants flow about in the hollow body through pipes while gas and liquid phases of the refrigerants are repeatedly separated and mixed for heat exchange between the fluid and the refrigerants. The apparatus comprises a plurality of plate-fin heat exchangers for exchanging heat between the refrigerants and the fluid, and a gas-liquid separator including upper and lower accommodation portions which are hollow cylinders laid in a horizontal direction both ends of which are airtightly sealed and an intermediate accommodation portion which connects the upper accommodation portion to the lower accommodation portion so as to form a sideways H-letter shape.Type: GrantFiled: November 7, 1995Date of Patent: January 28, 1997Assignee: Kabushiki Kaisha Kobe Seiko ShoInventors: Kazuhiko Asada, Koichi Ueno, Shin-ichiro Kashihara, Shigemi Okamoto, Katsuo Kurose, Kazuhiko Kuwahara, Ken-ichiro Mitsuhashi
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Patent number: 4766190Abstract: An elastomeric fluoropolymer comprising 12 to 50% by mole of repeating units derived from a perfluorovinyl ether of the formula:CF.sub.2 .dbd.CFO--(CF.sub.2 CFXO).sub.m --R.sub.f (I)wherein R.sub.f is a C.sub.1 -C.sub.6 perfluoroalkyl group, X is a fluorine atom or a trifluoromethyl group and m is an integer of 1 to 5, 50 to 88% by mole of repeating units derived from tetrafluoroethylene and 0.1 to 5% by mole of repeating units of hexafluoropropylene having improved strength and compression set.Type: GrantFiled: October 10, 1986Date of Patent: August 23, 1988Assignee: Daikin Industries Ltd.Inventors: Shigeru Morita, Kazuhiko Kuwahara, Masayasu Tomoda, Masahiko Oka