Patents by Inventor Kazuhiko Tabata
Kazuhiko Tabata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11155845Abstract: According to the present invention, theanine can efficiently be produced without exogenously adding ethylamine and without accumulation or leftover of ethylamine as a byproduct, by using a microorganism having enhanced activity to produce ethylamine with acetaldehyde and alanine as substrates and having enhanced activity of ?-glutamylmethylamide synthetase or glutaminase.Type: GrantFiled: April 12, 2018Date of Patent: October 26, 2021Assignee: KYOWA HAKKO BIO CO., LTD.Inventors: Kazuhiko Tabata, Shoto Ohno
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Publication number: 20200131546Abstract: According to the present invention, theanine can efficiently be produced without exogenously adding ethylamine and without accumulation or leftover of ethylamine as a byproduct, by using a microorganism having enhanced activity to produce ethylamine with acetaldehyde and alanine as substrates and having enhanced activity of ?-glutamylmethylamide synthetase or glutaminase.Type: ApplicationFiled: April 12, 2018Publication date: April 30, 2020Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Kazuhiko TABATA, Shoto OHNO
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Patent number: 10023884Abstract: According to the present invention, a microorganism belonging to the genus Aurantiochytrium having an 18S rRNA gene consisting of the base sequence represented by any of SEQ ID NOS: 1 to 5; Aurantiochytrium sp. OH4 strain; a microorganism which is a mutant obtained from the above-mentioned microorganism as a parent strain and has a higher ability to produce DHA than the parent strain; or Aurantiochytrium sp. LTR23 strain is provided. Also, a method for producing a DHA-containing composition, DHA and DHA alkyl ester by a fermentation process using the above-mentioned microorganisms is provided.Type: GrantFiled: January 17, 2014Date of Patent: July 17, 2018Assignee: KYOWA HAKKO BIO CO., LTD.Inventors: Tetsuro Ujihara, Megumi Nagano, Kazuhiko Tabata
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Publication number: 20160155284Abstract: A money processing apparatus according to an embodiment includes: a take out unit that takes out sheet-like moneys one by one; a denomination determining unit that determines denominations of the sheet-like moneys taken out by the tale out unit; and a plurality of processing units that discriminates the sheet-like moneys determined by the denomination determining unit and accumulates the sheet-like moneys according to the denomination, wherein power supply to the plurality of processing units having different denominations is individually controlled.Type: ApplicationFiled: November 25, 2015Publication date: June 2, 2016Inventor: Kazuhiko Tabata
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Publication number: 20150353972Abstract: According to the present invention, a microorganism belonging to the genus Aurantiochytrium having an 18S rRNA gene consisting of the base sequence represented by any of SEQ ID NOS: 1 to 5; Aurantiochytrium sp. OH4 strain; a microorganism which is a mutant obtained from the above-mentioned microorganism as a parent strain and has a higher ability to produce DHA than the parent strain; or Aurantiochytrium sp. LTR23 strain is provided. Also, a method for producing a DHA-containing composition, DHA and DHA alkyl ester by a fermentation process using the above-mentioned microorganisms is provided.Type: ApplicationFiled: January 17, 2014Publication date: December 10, 2015Inventors: Tetsuro Ujihara, Megumi Nagano, Kazuhiko Tabata
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Patent number: 8859241Abstract: Provided is a novel process for producing an L-amino acid using a microorganism belonging to the genus Escherichia. According to the present invention, a process for producing an L-amino acid comprising; culturing a microorganism in which an activity of the protein of any of the following [1]-[3] is increased compared with that of the parent strain in a medium, producing and accumulating the L-amino acid in the medium, and recovering the L-amino acid from the medium: [1] a protein comprising the amino acid sequence shown in SEQ ID NO: 2 [2] a protein consisting of an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence shown in SEQ ID NO: 2, and having YeiG activity [3] a protein consisting of an amino acid sequence having 80% or more homology to the amino acid sequence shown in SEQ ID NO: 2, and having YeiG activity.Type: GrantFiled: January 7, 2011Date of Patent: October 14, 2014Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Mikiro Hayashi, Kazuhiko Tabata
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Patent number: 8703447Abstract: Provided is an efficient process for producing L-glutamine or L-glutamic acid using a microorganism. L-glutamine or L-glutamic acid is produced by culturing in a medium a microorganism in which has an ability to produce L-glutamine or L-glutamic acid, and in which an ability to form a superhelical double-stranded DNA is decreased compared with that of the parent strain, producing and accumulating L-glutamine or L-glutamic acid in the medium, and recovering L-glutamine or L-glutamic acid from the medium.Type: GrantFiled: January 7, 2011Date of Patent: April 22, 2014Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Mikiro Hayashi, Kazuhiko Tabata, Yoshiyuki Yonetani
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Patent number: 8685914Abstract: The present invention provides: (1) crystals of a dipeptide which do not substantially comprise a dipeptide comprising D-amino acid as a constituent or a polypeptide consisting of three or more amino acids; and (2) crystals of a dipeptide which do not substantially comprise a dipeptide comprising D-amino acid as a constituent, a polypeptide consisting of three or more amino acids, or an amino acid amide; and a process for producing the dipeptide crystals.Type: GrantFiled: March 29, 2006Date of Patent: April 1, 2014Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Shin-ichi Hashimoto, Kazuhiko Tabata, Shizuo Tsuchiya, Tetsuo Nishimura
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Patent number: 8673590Abstract: The invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and in which an activity of the protein to transport a dipeptide in a microbial cell to theoutside of the microbial cell is higher than that of a parental strain.Type: GrantFiled: April 4, 2008Date of Patent: March 18, 2014Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Mikiro Hayashi, Kazuhiko Tabata, Makoto Yagasaki, Yoshiyuki Yonetani
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Patent number: 8647839Abstract: The invention provides a process for producing glutathione or ?-glutamylcysteine by culturing in a medium a microorganism with a higher activity of a protein having an activity to transport intracellular glutathione to the outside of cells, and a higher activity of a protein involved in glutathione or ?-glutamylcysteine biosynthesis, compared with that of the parent strain, forming and accumulating glutathione or ?-glutamylcysteine in the medium, and recovering the glutathione or ?-glutamylcysteine from the culture.Type: GrantFiled: April 4, 2008Date of Patent: February 11, 2014Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Kazuhiko Tabata, Yoshiyuki Yonetani
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Patent number: 8623619Abstract: The present invention provides a method of improving efficiency of a fermentative production of an L-amino acid.Type: GrantFiled: February 9, 2010Date of Patent: January 7, 2014Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Kazuhiko Tabata, Akihiro Senoo
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Patent number: 8435763Abstract: This invention relates to a process for producing a sugar nucleotide, in which a) a culture broth of a microorganism capable of producing NTP from a nucleotide precursor, or a treated product of the culture broth, and b) a culture broth of a microorganism capable of producing a sugar nucleotide from a sugar and NTP, or a treated product of the culture broth, are used as enzyme sources; a process for producing a complex carbohydrate, in which the above-described a) and b) and c) a culture broth of a microorganism, an animal cell or an insect cell capable of producing a complex carbohydrate from a sugar nucleotide and a complex carbohydrate precursor, or a treated product of the culture broth, are used as enzyme sources; a process for producing a complex carbohydrate, in which a culture broth of a microorganism, an animal cell or an insect cell capable of producing a complex carbohydrate from a sugar nucleotide and a complex carbohydrate precursor, or a treated product of the culture broth, is as an enzyme sourType: GrantFiled: September 14, 2004Date of Patent: May 7, 2013Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Satoshi Koizumi, Katsutoshi Sasaki, Tetsuo Endo, Kazuhiko Tabata, Akio Ozaki
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Publication number: 20120329106Abstract: Provided is a novel process for producing an L-amino acid using a microorganism belonging to the genus Escherichia. According to the present invention, a process for producing an L-amino acid comprising; culturing a microorganism in which an activity of the protein of any of the following [1]-[3] is increased compared with that of the parent strain in a medium, producing and accumulating the L-amino acid in the medium, and recovering the L-amino acid from the medium: [1] a protein comprising the amino acid sequence shown in SEQ ID NO: 2 [2] a protein consisting of an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence shown in SEQ ID NO: 2, and having YeiG activity [3] a protein consisting of an amino acid sequence having 80% or more homology to the amino acid sequence shown in SEQ ID NO: 2, and having YeiG activity.Type: ApplicationFiled: January 7, 2011Publication date: December 27, 2012Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Mikiro Hayashi, Kazuhiko Tabata
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Publication number: 20120322115Abstract: Provided is an efficient process for producing L-glutamine or L-glutamic acid using a microorganism. L-glutamine or L-glutamic acid is produced by culturing in a medium a microorganism in which has an ability to produce L-glutamine or L-glutamic acid, and in which an ability to form a superhelical double-stranded DNA is decreased compared with that of the parent strain, producing and accumulating L-glutamine or L-glutamic acid in the medium, and recovering L-glutamine or L-glutamic acid from the medium.Type: ApplicationFiled: January 7, 2011Publication date: December 20, 2012Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Mikiro Hayashi, Kazuhiko Tabata, Yoshiyuki Yonetani
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Patent number: 8211688Abstract: The present invention provides a microorganism belonging to the genus Escherichia in which the activities of glutamine-synthetase adenylyltransferase (GlnE protein) and PII regulatory protein for glutamine synthetase are reduced or lost and which has the ability to form and accumulate L-glutamine or a substance biosynthesized utilizing nitrogen supplied by L-glutamine, and a process for producing L-glutamine or the substance biosynthesized utilizing nitrogen supplied by L-glutamine using the microorganism.Type: GrantFiled: June 24, 2005Date of Patent: July 3, 2012Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Shin-ichi Hashimoto, Kazuhiko Tabata
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Publication number: 20120015409Abstract: The present invention provides a method of improving efficiency of a fermentative production of an L-amino acid.Type: ApplicationFiled: February 9, 2010Publication date: January 19, 2012Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Kazuhiko Tabata, Akihiro Senoo
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Patent number: 8039236Abstract: The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes the synthesis of a dipeptide, and a process for producing the dipeptide using a culture of a microorganism producing the protein which catalyzes the synthesis of a dipeptide or the like as an enzyme source.Type: GrantFiled: March 18, 2009Date of Patent: October 18, 2011Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Shin-ichi Hashimoto, Kazuhiko Tabata, Aya Kubota, Hajime Ikeda
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Patent number: 7939302Abstract: The present invention provides a process for producing a dipeptide which comprises culturing in a medium a microorganism which has the ability to produce a protein having the activity to form the dipeptide from one or more kinds of amino acids and which has the ability to produce at least one of said one or more kinds of amino acids, allowing the dipeptide to form and accumulate in the medium, and recovering the dipeptide from the medium.Type: GrantFiled: March 10, 2009Date of Patent: May 10, 2011Assignee: Kyowa Hakko Bio Co., Ltd.Inventors: Shin-ichi Hashimoto, Kazuhiko Tabata
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Publication number: 20100203592Abstract: The invention provides a process for producing glutathione or ?-glutamylcysteine by culturing in a medium a microorganism with a higher activity of a protein having an activity to transport intracellular glutathione to the outside of cells, and a higher activity of a protein involved in glutathione or ?-glutamylcysteine biosynthesis, compared with that of the parent strain, forming and accumulating glutathione or ?-glutamylcysteine in the medium, and recovering the glutathione or ?-glutamylcysteine from the culture.Type: ApplicationFiled: April 4, 2008Publication date: August 12, 2010Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Kazuhiko Tabata, Yoshiyuki Yonetani
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Publication number: 20100129867Abstract: The invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and in which an activity of the protein to transport a dipeptide in a microbial cell to the outside of the microbial cell is higher than that of a parental strain.Type: ApplicationFiled: April 4, 2008Publication date: May 27, 2010Applicant: KYOWA HAKKO BIO CO., LTD.Inventors: Mikiro Hayashi, Kazuhiko Tabata, Makoto Yagasaki, Yoshiyuki Yonetani