Patents by Inventor Kazuhiko Totsuka

Kazuhiko Totsuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9173407
    Abstract: Infection of pathogens is controlled by inducing disease resistance with a method of treating a plant with a composition of an acidic heat-treated solution of microorganisms.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: November 3, 2015
    Assignee: AJINOMOTO CO., INC.
    Inventors: Daisuke Igarashi, Taito Takeda, Takashi Ishizaki, Kazuhiko Totsuka
  • Publication number: 20100330055
    Abstract: Infection of pathogens is controlled by inducing disease resistance with a method of treating a plant with a composition of an acidic heat-treated solution of microorganisms.
    Type: Application
    Filed: July 9, 2010
    Publication date: December 30, 2010
    Inventors: Daisuke Igarashi, Taito Takeda, Takashi Ishizaki, Kazuhiko Totsuka
  • Patent number: 7501268
    Abstract: A method of producing a prenyl alcohol, comprising creating a recombinant by transferring into a host a recombinant DNA for expression or a DNA for genomic integration each comprising a prenyl diphosphate synthase gene or a mutant thereof, culturing the resultant recombinant, and recovering the prenyl alcohol from the resultant culture.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: March 10, 2009
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Chikara Ohto, Shusei Obata, Masayoshi Muramatsu, Kiyohiko Nishi, Kazuhiko Totsuka
  • Patent number: 7189543
    Abstract: Cadaverine dicarboxylate is produced by performing an enzymatic decarboxylation reaction of a lysine solution while adding a dicarboxylic acid containing 4 to 10 carbons to the lysine solution to maintain pH of the solution at a level sufficient for the enzymatic decarboxylation reaction to occur, for example, 4.0 to 8.0.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: March 13, 2007
    Assignee: Ajinomoto Co., Inc.
    Inventors: Kiyohiko Nishi, Shuichi Endo, Yukiko Mori, Kazuhiko Totsuka, Yoshinori Hirao
  • Publication number: 20050003497
    Abstract: Cadaverine dicarboxylate is produced by performing an enzymatic decarboxylation reaction of a lysine solution while adding a dicarboxylic acid containing 4 to 10 carbons to the lysine solution to maintain pH of the solution at a level sufficient for the enzymatic decarboxylation reaction to occur, for example, 4.0 to 8.0.
    Type: Application
    Filed: May 24, 2004
    Publication date: January 6, 2005
    Inventors: Kiyohiko Nishi, Shuichi Endo, Yukiko Mori, Kazuhiko Totsuka, Yoshinori Hirao
  • Patent number: 5830716
    Abstract: A method of producing a target substance by microbial fermentation, where the natural ability of the microorganism to produce NADPH from NADH is increased. The present method is useful for producing a wide variety of materials, such as amino acids, antibiotics, vitamins, growth factors and other physiologically active substances. The microorganism is modified to increase production of NADPH from NADH in order to increase the amount of an active substance in the culture medium. The modification of the microorganism results in the increased production of the amount of nicotinamide nucleotide transhydrogenase expressed by the microorganism. Further, the increase in the production of NADPH from NADH is increased by increasing the number of copies of a gene encoding a nicotinamide nucleotide transhydrogenase enzyme. The copies of the gene are so produced to a number effective to increase the amount of the enzyme expressed by the microorganism, thereby increasing the enzyme activity of the microorganism.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: November 3, 1998
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hiroyuki Kojima, Kazuhiko Totsuka
  • Patent number: 5362636
    Abstract: A process for producing L-lysine, which comprises culturing a mutant L-lysine-producing strain belonging to the genus Brevibacterium or the genus Corynebacterium and having selenalysine resistance in a nutrient medium, producing and accumulating L-lysine in the culture broth and collecting L-lysine from the culture broth.
    Type: Grant
    Filed: October 22, 1991
    Date of Patent: November 8, 1994
    Assignee: Ajinomoto Co., Inc.
    Inventors: Manabu Yokomori, Takeshi Niwa, Kazuhiko Totsuka, Yoshio Kawahara, Shigeru Nakamori, Nobuyoshi Esaki, Kenji Soda
  • Patent number: 5304476
    Abstract: The present invention relates to a fermentation process using a L-lysine-producing microorganism having a resistance to an acyl-lysine, a methylated acyl-lysine or both an acyl-lysine and a methylated acyl-lysine. By the process of the present invention, L-lysine may be produced in high yields providing an improved process that reduces the cost of industrially produced L-lysine.
    Type: Grant
    Filed: March 3, 1992
    Date of Patent: April 19, 1994
    Assignee: Ajinomoto Co., Inc.
    Inventors: Manabu Yokomori, Kazuhiko Totsuka, Yoshio Kawahara, Harufumi Miwa, Tsuyoshi Osumi