Patents by Inventor Kazuko Toh

Kazuko Toh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition controlling pharmacokinetics in the body
    Patent number: 11957708
    Abstract: The present invention provides a composition that controls pharmacokinetics. Specifically, the present invention provides: a composition for controlling pharmacokinetics, the composition containing a polyvalent cation as an active ingredient; and a method for controlling pharmacokinetics using the polyvalent cation.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: April 16, 2024
    Assignee: KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Kazunori Kataoka, Shigehito Osawa, Satoshi Uchida, Kotaro Hayashi, Anjaneyulu Dirisala, Kazuko Toh
  • Nucleic acid-loaded unit polyion complex
    Patent number: 11324835
    Abstract: A unit-type polyion complex for use in delivering nucleic acid to a target site in a patient includes one or more molecules of a block copolymer having a poly(ethylene glycol) segment and a cationic poly(amino acid) segment and one or more molecules of a nucleic acid. A total quantity of positive charges derived from side chains of the cationic poly(amino acid) segment of the block copolymer in the unit-type polyion complex is not offset by a total quantity of negative charges derived from the nucleic acid. Furthermore, the nucleic acid has a strand length of 10-50 bases, the molecular weight of the poly(ethylene glycol) segment is 40×103 or more, and the block copolymer has a binding constant (Ka) for the nucleic acid of 3.0×105 or more.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: May 10, 2022
    Assignees: KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION, THE UNIVERSITY OF TOKYO
    Inventors: Kazunori Kataoka, Kanjiro Miyata, Shigeto Fukushima, Kotaro Hayashi, Sumiyo Watanabe, HyunJin Kim, Kazuko Toh
  • COMPOSITION CONTROLLING PHARMACOKINETICS IN THE BODY
    Publication number: 20210038634
    Abstract: The present invention provides a composition that controls pharmacokinetics. Specifically, the present invention provides: a composition for controlling pharmacokinetics, the composition containing a polyvalent cation as an active ingredient; and a method for controlling pharmacokinetics using the polyvalent cation.
    Type: Application
    Filed: March 12, 2019
    Publication date: February 11, 2021
    Applicant: KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Kazunori KATAOKA, Shigehito OSAWA, Satoshi UCHIDA, Kotaro HAYASHI, Anjaneyulu DIRISALA, Kazuko TOH
  • NUCLEIC ACID-LOADED UNIT POLYION COMPLEX
    Publication number: 20200197527
    Abstract: A unit-type polyion complex for use in delivering nucleic acid to a target site in a patient includes one or more molecules of a block copolymer having a poly(ethylene glycol) segment and a cationic poly(amino acid) segment and one or more molecules of a nucleic acid. A total quantity of positive charges derived from side chains of the cationic poly(amino acid) segment of the block copolymer in the unit-type polyion complex is not offset by a total quantity of negative charges derived from the nucleic acid. Furthermore, the nucleic acid has a strand length of 10-50 bases, the molecular weight of the poly(ethylene glycol) segment is 40×103 or more, and the block copolymer has a binding constant (Ka) for the nucleic acid of 3.0×105 or more.
    Type: Application
    Filed: August 30, 2018
    Publication date: June 25, 2020
    Inventors: Kazunori KATAOKA, Kanjiro MIYATA, Shigeto FUKUSHIMA, Kotaro HAYASHI, Sumiyo WATANABE, HyunJin KIM, Kazuko TOH
  • Polymerized cyclic nitroxide radical compound and use thereof
    Patent number: 8980241
    Abstract: A method of covalently bonding a cyclic nitroxide radical compound to a hydrophobic block of a specific hydrophylic-phobic block copolymer, and polymerized cyclic nitroxide radical compound copolymerized in this manner, as well as use of such a compound, for instance, in the medical field are provided. The compound demonstrates long term stability in vivo under reductive environment.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: March 17, 2015
    Assignee: University of Tsukuba
    Inventors: Yukio Nagasaki, Toru Yoshitomi, Hirofumi Matsui, Aki Hirayama, Takashi Mamiya, Akira Matsumura, Kensuke Suzuki, Hideo Tsurushima, Aiki Marushima, Kazuko Toh, Daisuke Miyamoto
  • POLYMERIZED CYCLIC NITROXIDE RADICAL COMPOUND AND USE THEREOF
    Publication number: 20110142787
    Abstract: A method of covalently bonding a cyclic nitroxide radical compound to a hydrophobic block of a specific hydrophylic-phobic block copolymer, and polymerized cyclic nitroxide radical compound copolymerized in this manner, as well as use of such a compound, for instance, in the medical field are provided. The compound demonstrates long term stability in vivo under reductive environment.
    Type: Application
    Filed: December 4, 2008
    Publication date: June 16, 2011
    Inventors: Yukio Nagasaki, Toru Yoshitomi, Hirofumi Matsui, Aki Hirayama, Takashi Mamiya, Akira Matsumura, Kensuke Suzuki, Hideo Tsurushima, Aiki Marushima, Kazuko Toh, Daisuke Miyamoto