Abstract: Provided is a pharmaceutical composition excellent in capability of an accelerated penetration into an affected area. The pharmaceutical composition capable of accelerated penetration into the affected area is formed by dispersing nano-bubbles, which are negatively charged and are given high internal pressures due to their surface tension, in the pharmaceutical composition in a form of a liquid or a gel including a predetermined drug.

Abstract: A membrane separation culture device includes an upper structure including a vessel in which at least a portion of the bottom thereof is formed with a separation membrane having pores that allow stem cells to permeate therethrough, and a lower structure including a vessel that retains a fluid in which the membrane of the upper structure is immersed.

Abstract: A restarting device of a pump including a center rod defining fluid delivering chambers and driving chambers 11b and 12b. The restarting device of the pump further includes: a change-over valve 2 for switching a direction for the center rod to move, and a restarting hydraulic circuit 3 which, when a supply of the driving fluid from the change-over valve 2 to the driving chambers 11b and 12b in both sides is stopped, detects the supply of the driving fluid into the driving chambers 11b and 12b in both sides having been stopped and then causes the driving fluid to flow into the change-over valve, thereby restarting the supply of the driving fluid into the driving chambers 11b and 12b.

Abstract: An object of the present invention is to provide a restarting device of a pump for restarting an operation of the pump automatically in such an event that the operation of the pump is shut down due to a change-over valve stopping in an intermediate position, which valve has been moved forth and back to switch a direction for a center rod of the pump to move.

Abstract: A diaphragm pump is provided with a diaphragm defining a pump chamber and a drive chamber in the pump housing, a driving fluid is supplied to the drive chamber and a pump fluid is expelled from the pump chamber. The diaphragm pump is provided with pressure control means which, when the pressure in the pump chamber surpasses the pressure in the drive chamber neighboring the pump chamber across the diaphragm, controls the pressure of the driving fluid based upon output signals from pressure sensors in such a manner that the pressure in the fluid chamber will become higher than the pressure in the neighboring drive chamber. This makes it possible to prevent a diaphragm reversal phenomenon, wherein a diaphragm that should expand toward the pump chamber contracts toward the drive chamber instead during reciprocation of the diaphragm.

Abstract: A diaphragm assembly has a center disk in which use of a metal member is not required. The center disk comprises first and second center disk members, made of resin, embracing a resin diaphragm between them. The first center disk member has an inwardly directed inner flange on an inner peripheral wall defining a resin charging space, and the second center disk member comprises a resin-molded body, formed by charging a resin, and has an outwardly directed outer flange. A portion of the diaphragm is clamped between the inner flange and the outer flange.

Abstract: A diaphragm assembly has a center disk in which use of a metal member is not required. The center disk comprises first and second center disk members, made of resin, embracing a resin diaphragm between them. The first center disk member has an inwardly directed inner flange on an inner peripheral wall defining a resin charging space, and the second center disk member comprises a resin-molded body, formed by charging a resin, and has an outwardly directed outer flange. A portion of the diaphragm is clamped between the inner flange and the outer flange.

Abstract: The objective of the present invention is to provide a reciprocation switching device for a pump which will solve problems of conventional devices such as that, because coil springs are used for activating by their snap action valve operators or switching operators serving to control the pressure of pump working fluid in relation to reciprocating action of the pump, such devices require the numerous number of parts including spring fitting shafts, the structure to attach such fitting shafts, parts for spring holders, etc.; and that the assembling of those parts is troublesome. A device according to the present invention uses one or two wire springs made into a C-like shape as the springs for the aforementioned purpose and calls for fitting said springs directly between the spring fitting section(s) and the valve operator or the switching operator.

Abstract: The objective of the present invention is to provide a reciprocation switching device for a pump which will solve problems of conventional devices such as that, because coil springs are used for activating by their snap action valve operators or switching operators serving to control the pressure of pump working fluid in relation to reciprocating action of the pump, such devices require the numerous number of parts including spring fitting shafts, the structure to attach such fitting shafts, parts for spring holders, etc.; and that the assembling of those parts is troublesome. A device according to the present invention uses one or two springs made into a C-like shape as the springs for the aforementioned purpose and calls for fitting said springs directly between the spring fitting section(s) and the valve operator or the switching operator.

Abstract: The objective of the present invention is to provide a reciprocation switching device for a pump which will solve problems of conventional devices such as that, because coil springs are used for activating by their snap action valve operators or switching operators serving to control the pressure of pump working fluid in relation to reciprocating action of the pump, such devices require the numerous number of parts including spring fitting shafts, the structure to attach such fitting shafts, parts for spring holders, etc.; and that the assembling of those parts is troublesome. A device according to the present invention uses one or two wire springs made into a C-like shape as the springs for the aforementioned purpose and calls for fitting said springs directly between the spring fitting sections(s) and the valve operator or the switching operator.

Abstract: A spool type switching valve to be used for the switching operation of a diaphragm pump or a similar device, which simultaneously insures both preventing abrasion of the detent mechanism and obtaining thorough operation of switching the spool. A spool is movably fitted inside a sleeve and is prevented from standing still at a neutral point by a detent mechanism provided at one of its ends. The detent mechanism comprises a spool operator fitted around a shaft section at one end of the spool as one body, a spring holder at the end of the sleeve retains a pair of C-shaped wire springs of a circular cross-section fitted between the spool operator and the spring holder. As the spool passes the neutral point, spring forces snap the spool to the extremity of its range, thereby preventing stopping of the spool in the neutral position. An axial clearance permits the spool operator to begin moving before the spool moves.

Abstract: A pressure chamber of a diaphragm pump having an outer chamber improved so that it is free from stress concentration. The inner wall surface of the pressure chamber is recessed in a mero-spherical shape. In order to support this chamber wall from its rear side, an outer ring rib is provided along the outermost periphery of the outer surface of the chamber, and an inner ring rib is circumferentially disposed at the inner side of the outer ring rib. Further, radial ribs are provided so as to connect together the outer and inner ring ribs in the radial direction.