Patents by Inventor Kazumasa Yokoyama
Kazumasa Yokoyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180312566Abstract: Provided is an Fc fusion high affinity IgE receptor ?-chain having excellent stability at low pH. An Fc fusion protein comprising: (i) a high affinity IgE receptor ?-chain; and (ii) an Fc region of IgG1, wherein a linker fragment region between the (i) and the (ii) is the amino acid sequence shown in SEQ ID NO: 2.Type: ApplicationFiled: July 13, 2018Publication date: November 1, 2018Applicant: Kissei Pharmaceutical Co., Ltd.Inventors: Takashi Sakamoto, Yoichi Inada, Kazumasa Yokoyama
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Patent number: 10077297Abstract: Provided is an Fc fusion high affinity IgE receptor ?-chain having excellent stability at low pH. An Fc fusion protein comprising: (i) a high affinity IgE receptor ?-chain; and (ii) an Fc region of IgG1, wherein a linker fragment region between the (i) and the (ii) is the amino acid sequence shown in SEQ ID NO: 2.Type: GrantFiled: February 19, 2016Date of Patent: September 18, 2018Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Takashi Sakamoto, Yoichi Inada, Kazumasa Yokoyama
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Patent number: 10047139Abstract: Provided is an Fc fusion high affinity IgE receptor ?-chain having excellent stability at low pH. An Fc fusion protein comprising: (i) a high affinity IgE receptor ?-chain; and (ii) an Fc region of IgG1, wherein a linker fragment region between the (i) and the (ii) is the amino acid sequence shown in SEQ ID NO: 2.Type: GrantFiled: February 19, 2016Date of Patent: August 14, 2018Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Takashi Sakamoto, Yoichi Inada, Kazumasa Yokoyama
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Publication number: 20180044402Abstract: Provided is an Fc fusion high affinity IgE receptor ?-chain having excellent stability at low pH. An Fc fusion protein comprising: (i) a high affinity IgE receptor ?-chain; and (ii) an Fc region of IgG1, wherein a linker fragment region between the (i) and the (ii) is the amino acid sequence shown in SEQ ID NO: 2.Type: ApplicationFiled: February 19, 2016Publication date: February 15, 2018Applicant: Kissei Pharmaceutical Co., Ltd.Inventors: Takashi Sakamoto, Yoichi INADA, Kazumasa YOKOYAMA
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Publication number: 20090032993Abstract: A drum cleaning device (65) has a nozzle (66). The drum cleaning device (65) is disposed in the upstream from a peel roller (34). A dope (21) is cast onto a surface of the casting drum(32) by using a casting die (30). The casting drum(32) is rotated to form a casting film(33) on the surface. The casting film(33) is cooled by the casting drum(32). Deposits containing fatty acid ester as a main component are precipitated from the casting film(33) onto the surface. The peel roller (34) peels off the casting film(33) as a wet film(38). The drum cleaning device (65) blasts gas mixture containing air and dry ice particles from the nozzle (66) onto the surface.Type: ApplicationFiled: March 7, 2007Publication date: February 5, 2009Applicant: FUJIFILM CORPORATIONInventor: Kazumasa Yokoyama
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Publication number: 20080203595Abstract: A dope is cast onto a drum whose surface is cooled, so as to form a casting film. After the peeling of the casting film, a cleaning gas containing dry ice particles is applied to a periphery of the casting drum with use of a drum cleaning unit. Thus the dry ice particles collide to the periphery of the casting drum, and the colliding energy is effective of removing from the periphery an organic material adhered on the casting drum. The organic material mainly contains aliphatic acid, aliphatic acid ester and metal salt of aliphatic acid. Before the increase of the amount of the organic material, it is removed and therefore isn't transmitted onto the surface of the casting film. Thus a high quality film having no optical unevenness is produced without the decrease of the productivity.Type: ApplicationFiled: February 21, 2008Publication date: August 28, 2008Inventors: Kazumasa YOKOYAMA, Ryou Takeda
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Patent number: 6617133Abstract: The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a-culture medium containing rHSA and the rHSA-producing host cells, feeding said heated solution upwardly into a fluidized bed in which adsorbent particles are suspended to effect contacting with the adsorbent particles and then recovering the adsorbed fraction containing the rHSA, and a composition comprising rHSA which shows a A350/A280 ratio of below 0.015, when formulated into a 25% solution of said albumin.Type: GrantFiled: May 24, 1999Date of Patent: September 9, 2003Assignee: Mitsubishi Pharma CorporationInventors: Munehiro Noda, Akinori Sumi, Takao Ohmura, Kazumasa Yokoyama
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Patent number: 6475506Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartment separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.Type: GrantFiled: February 10, 1999Date of Patent: November 5, 2002Assignee: Yoshitomi PharmaceuticalInventors: Tadaaki Inoue, Hideto Kodaira, Yoshihito Nawa, Ryoichiro Murashima, Shunichi Abe, Kazumasa Yokoyama
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Patent number: 6129925Abstract: An object of the present invention is to provide an infusion preparation set (a container filled with infusion liquids) useful for preparation of an infusion liquid containing sugars, amino acids, electrolytes, a fat emulsion and vitamins. The present invention is constituted by the use of a container having two compartments which are separated from each other by a separation means, which contains an infusion liquid comprising a fat emulsion, sugars, fat-soluble vitamins and specified water-soluble vitamins in the first compartment and an infusion liquid comprising amino acids, electrolytes and other specified water-soluble vitamins in the second compartment. An infusion preparation containing sugars, amino acids, electrolytes, a fat emulsion and vitamins can be obtained easily and aseptically upon use, by simply removing a separation means and mixing the infusion liquids included in the first and second compartments.Type: GrantFiled: March 2, 1998Date of Patent: October 10, 2000Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Takae Kido, Shigeo Ii, Shun-ichi Abe, Kazumasa Yokoyama
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Patent number: 5993863Abstract: The present invention aims at providing an alimentative infusion liquid which has improved stability and preservability and can be administered through a peripheral vein. The infusion liquid contains sugars, amino acids, electrolytes and a fat emulsion at a specific mixing ratio and has a specific pH value and a titratable acidity. The alimentative infusion liquid of the present invention containing the above-described components has good preservability without suffering from precipitation, denaturation and the like problems. Further, since the pH value is adjusted to a specific level and the titratable acidity is retained low, administration of the infusion liquid through a peripheral vein does not cause troubles such as angialiga.Type: GrantFiled: October 7, 1997Date of Patent: November 30, 1999Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Masahiro Kikuchi, Yoshihiko Okutani, Tadaaki Inoue, Ryoichiro Murashima, Shunichi Abe, Hiroshi Koshiba, Hiroshi Shibata, Shunichiro Ishii, Yoshiyasu Kawabata, Kazumasa Yokoyama
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Patent number: 5986062Abstract: Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatment and another ultrafiltration, followed by subsequent treatments with a cation exchanger, a hydrophobic chromatography carrier and an anion exchanger, and by salting-out to thereby obtain a pure form of human serum albumin which contains substantially no proteinous and polysaccharide contaminants, which is formulated into a pharmaceutical preparation. The thus obtained human serum albumin can further be purified by treating recombinant human serum albumin with a hydrophobic chromatography carrier at pH of 2 to 5 and a salt concentration of 0.4 to 1 and exposing the carrier to a pH of 6 to 8 and a salt concentration of 0.01 to 0.Type: GrantFiled: October 3, 1995Date of Patent: November 16, 1999Assignee: The Green Cross CorporationInventors: Takao Ohmura, Akinori Sumi, Wataru Ohtani, Naoto Furuhata, Kazuya Takeshima, Kaeko Kamide, Munehiro Noda, Masahide Kondo, Syoichi Ishikawa, Kazuhiro Oohara, Kazumasa Yokoyama, Nagatoshi Fujiwara
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Patent number: 5972367Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.Type: GrantFiled: June 7, 1995Date of Patent: October 26, 1999Assignee: The Green Cross CorporationInventors: Tadaaki Inoue, Hideto Kodaira, Yoshihito Nawa, Ryoichiro Murashima, Shunichi Abe, Kazumasa Yokoyama
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Patent number: 5962649Abstract: The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a culture medium containing rHSA and the rHSA-producing host cello, feeding said heated solution upwardly into a fluidized bed in which adsorbent particles are suspended to effect contacting with the adsorbent particles and then recovering the adsorbed fraction containing the rHSA, and a composition comprising rHSA which shows a A35D/A280 ratio of below 0.015, when formulated into a 25% solution of said albumin.Type: GrantFiled: August 31, 1995Date of Patent: October 5, 1999Assignee: Yoshitomo Pharmaceutical Industries, Ltd.Inventors: Munehiro Noda, Akinori Sumi, Takao Ohmura, Kazumasa Yokoyama
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Patent number: 5770233Abstract: An object of the present invention is to provide an infusion preparation set (a container filled with infusion liquids) useful for preparation of an infusion liquid containing sugars, amino acids, electrolytes, a fat emulsion and vitamins. The present invention is constituted by the use of a container having two compartments which are separated from each other by a separation means, which contains an infusion liquid comprising a fat emulsion, sugars, fat-soluble vitamins and specified water-soluble vitamins in the first compartment and an infusion liquid comprising amino acids, electrolytes and other specified water-soluble vitamins in the second compartment. An infusion preparation containing sugars, amino acids, electrolytes, a fat emulsion and vitamins can be obtained easily and aseptically upon use, by simply removing a separation means and mixing the infusion liquids included in the first and second compartments.Type: GrantFiled: April 21, 1995Date of Patent: June 23, 1998Assignee: The Green Cross CorporationInventors: Takae Kido, Shigeo Ii, Shun-ichi Abe, Kazumasa Yokoyama
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Patent number: 5728681Abstract: A container filled with infusion liquids useful for preparation of an infusion liquid containing sugars, amino acids, electrolytes, a fat emulsion and vitamins. A container having two compartments which are separated from each other by a separation means, which contains an infusion liquid comprising a fat emulsion, sugars and specific vitamins in the first compartment and an infusion liquid comprising amino acids, electrolytes and other specific vitamins in the second compartment. An infusion preparation containing sugars, amino acids, electrolytes, a fat emulsion and vitamins can be obtained easily and aseptically upon use, by simply removing a separation means and mixing the infusion liquids included in the first and second compartments.Type: GrantFiled: December 20, 1995Date of Patent: March 17, 1998Assignee: The Green Cross CorporationInventors: Takae Kido, Hideto Kodaira, Koji Munechika, Shigeo Ii, Shunichi Abe, Kazumasa Yokoyama
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Patent number: 5674527Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.Type: GrantFiled: June 7, 1995Date of Patent: October 7, 1997Assignee: The Green Cross CorporationInventors: Tadaaki Inoue, Hideto Kodaira, Yoshihito Nawa, Ryoichiro Murashima, Shunichi Abe, Kazumasa Yokoyama
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Patent number: 5643792Abstract: A methylotrophic and glucotrophic mutant strain capable of producing a heterologous protein and a method for producing a heterologous protein, comprising culture of the mutant strain. The mutant strain of the present invention can be grown in a medium containing both methanol and glucose, with the effect that the growth of the strain and production of a heterologous protein proceed at the same time. Accordingly, a heterologous protein can be produced in a large amount in a short time.Type: GrantFiled: January 13, 1994Date of Patent: July 1, 1997Assignee: The Green Cross CorporationInventors: Ken Okabayashi, Takao Ohmura, Kazumasa Yokoyama, Haruhide Kawabe
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Patent number: 5626880Abstract: Disclosed is an infusion preparation for nutrient supply use. It comprises a sugar, amino acids, electrolytes and a fat emulsion. It has an excellent shelf life without causing precipitation, denaturation and the like in spite of the simultaneous presence of these components. Also disclosed is a container filled with infusion liquids comprising a first and a second compartments separated from each other by a separation means, wherein an infusion liquid containing a fat emulsion and a sugar is included in the first compartment and another infusion liquid containing amino acids and electrolytes is included in the second compartment. Further disclosed are an infusion preparation comprising a fat emulsion and a sugar, and an infusion preparation comprising amino acids and electrolytes.Type: GrantFiled: January 22, 1996Date of Patent: May 6, 1997Assignee: The Green Cross CorporationInventors: Tadaaki Inoue, Hideto Kodaira, Yoshihito Nawa, Ryoichiro Murashima, Shunichi Abe, Kazumasa Yokoyama
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Patent number: 5610169Abstract: The orally administrable pharmaceutical compositions containing a slightly water-soluble drug, characterized by improved stability and improved absorption of the drug from digestive tract into blood. The use of the compositions of the present invention enables decrease of the dose amount of a slightly water-soluble drug, which eventually leads to alleviation of pains and side effects on the part of patients.Type: GrantFiled: June 7, 1995Date of Patent: March 11, 1997Assignee: The Green Cross CorporationInventors: Toru Iwao, Kenichi Hirai, Nobuo Kondoh, Koichi Yamanouchi, Kazumasa Yokoyama
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Patent number: 5589516Abstract: A liquid preparation of antithrombin-III (AT-III), comprising an AT-III and an organic acid, a salt thereof, a sugar sulfate or a surfactant as a stabilizer, and a liquid preparation of AT-III, having a pH of 9-10. The preparation of the present invention is stable after long-term preservation and poses no clinical problems in terms of pharmacological effects and safety. The preparation is more advantageous than lyophilized preparations in that it does not require dissolution in injectable distilled water and can be used easily. Accordingly, the preparation is clinically very useful.Type: GrantFiled: December 5, 1994Date of Patent: December 31, 1996Assignee: The Green Cross CorporationInventors: Katsuhiro Uriyu, Akimasa Ohmizu, Hajime Fukuyama, Kazuo Takechi, Kazumasa Yokoyama