Patents by Inventor Kazuo Fujikawa

Kazuo Fujikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal of a truncated protein construct containing a coagulation factor VIII C2 domain in the presence or absence of a bound ligand and methods of use thereof
    Publication number: 20060293505
    Abstract: A detailed three-dimensional structure for the C-terminal C2 domain of blood coagulation factor VIII is disclosed. The novel truncated factor VIII constructs which were designed so as to omit a significant portion of the flexible full length protein are also part of the present invention. In addition, the crystals of the protein, both in the presence and absence of bound ligands are also included. Furthermore, methods of identifying antagonists of the human factor VIII protein which can be used to inhibit coagulation or to stabilize and activate factor VIII mutants are also disclosed. Furthermore, methods of identifying variations of the C2 domain sequence and structure that can be incorporated into intact factor VIII for the purpose Of administration to hemophiliac patients who are immunoreactive against wild type factor VIII are disclosed.
    Type: Application
    Filed: January 19, 2006
    Publication date: December 28, 2006
    Inventors: Barry Stoddard, Kathleen Pratt, Kazuo Fujikawa, Earl Davie
  • Phospholipid-targeted thrombolytic agents
    Patent number: 5632986
    Abstract: Conjugates with an affinity for phospholipids are disclosed. The conjugates comprise a first compound having affinity for phospholipids, with a binding constant that is not greater than about 10.sup.-7 M and a second compound that lyses thrombi or is a precursor of a compound that lyses thrombi.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: May 27, 1997
    Assignee: The University of Washington
    Inventors: Jonathan F. Tait, Kazuo Fujikawa
  • Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity
    Patent number: 4937324
    Abstract: Proteins having therapeutic potential as both anticoagulants and as anti-inflammatory agents are disclosed. The present invention also discloses the use of lipocortins in reducing blood coagulation in warm-blooded animals.
    Type: Grant
    Filed: February 4, 1988
    Date of Patent: June 26, 1990
    Assignees: ZymoGenetics, Inc., The Board of Regents of the University of Washington
    Inventors: Kazuo Fujikawa, Meher H. Irani, Bruce L. A. Carter