Patents by Inventor Kazuyoshi MARUBAYASHI

Kazuyoshi MARUBAYASHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline form of sofpironium bromide and preparation method thereof
    Patent number: 11584715
    Abstract: A cocrystal containing the 1?R-diastereomer and the 1?S-diastereomer of sofpironium bromide at a ratio of 1:3 (Form CO), a crystal mixture (for example, Form B) containing Form CO and a crystalline form of the 1?R-diastereomer (Form MN), and a method for preparing sofpironium bromide, which is suitable for manufacture of the crystal mixture are provided. Form CO and a crystalline form of sofpironium bromide containing Form CO (for example, Form B) have superior stability without hygroscopic property, and accordingly they can be preferably used as a raw material of medicaments.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: February 21, 2023
    Assignee: Botanix SB, Inc.
    Inventors: Kazuyoshi Marubayashi, Masahito Watanabe, Herbert R. Brinkman
  • Crystalline form of sofpironium bromide and preparation method thereof
    Patent number: 11566000
    Abstract: A cocrystal containing the 1?R-diastereomer and the 1'S-diastereomer of sofpironium bromide at a ratio of 1:3 (Form CO), a crystal mixture (for example, Form B) containing Form CO and a crystalline form of the 1?R-diastereomer (Form MN), and a method for preparing sofpironium bromide, which is suitable for manufacture of the crystal mixture are provided. Form CO and a crystalline form of sofpironium bromide containing Form CO (for example, Form B) have superior stability without hygroscopic property, and accordingly they can be preferably used as a raw material of medicaments.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: January 31, 2023
    Assignee: Botanix SB, Inc.
    Inventors: Kazuyoshi Marubayashi, Masahito Watanabe, Herbert R. Brinkman
  • CRYSTALLINE FORM OF SOFPIRONIUM BROMIDE AND PREPARATION METHOD THEREOF
    Publication number: 20220298108
    Abstract: A cocrystal containing the 1?R-diastereomer and the 1?S-diastereomer of sofpironium bromide at a ratio of 1:3 (Form CO), a crystal mixture (for example, Form B) containing Form CO and a crystalline form of the 1?R-diastereomer (Form MN), and a method for preparing sofpironium bromide, which is suitable for manufacture of the crystal mixture are provided. Form CO and a crystalline form of sofpironium bromide containing Form CO (for example, Form B) have superior stability without hygroscopic property, and accordingly they can be preferably used as a raw material of medicaments.
    Type: Application
    Filed: May 22, 2020
    Publication date: September 22, 2022
    Applicants: Kaken Pharmaceutical Co., Ltd., Brickell Biotech, Inc.
    Inventors: Kazuyoshi MARUBAYASHI, Masahito WATANABE, Herbert R. BRINKMAN
  • CRYSTALLINE FORM OF SOFPIRONIUM BROMIDE AND PREPARATION METHOD THEREOF
    Publication number: 20210395197
    Abstract: A cocrystal containing the 1?R-diastereomer and the 1?S-diastereomer of sofpironium bromide at a ratio of 1:3 (Form CO), a crystal mixture (for example, Form B) containing Form CO and a crystalline form of the 1?R-diastereomer (Form MN), and a method for preparing sofpironium bromide, which is suitable for manufacture of the crystal mixture are provided. Form CO and a crystalline form of sofpironium bromide containing Form CO (for example, Form B) have superior stability without hygroscopic property, and accordingly they can be preferably used as a raw material of medicaments.
    Type: Application
    Filed: June 30, 2021
    Publication date: December 23, 2021
    Applicants: Kaken Pharmaceutical Co., Ltd., Brickell Biotech, Inc.
    Inventors: Kazuyoshi MARUBAYASHI, Masahito WATANABE, Herbert R. BRINKMAN
  • CRYSTALLINE FORM OF SOFPIRONIUM BROMIDE AND PREPARATION METHOD THEREOF
    Publication number: 20210171460
    Abstract: A cocrystal containing the 1?R-diastereomer and the 1'S-diastereomer of sofpironium bromide at a ratio of 1:3 (Form CO), a crystal mixture (for example, Form B) containing Form CO and a crystalline form of the 1?R-diastereomer (Form MN), and a method for preparing sofpironium bromide, which is suitable for manufacture of the crystal mixture are provided. Form CO and a crystalline form of sofpironium bromide containing Form CO (for example, Form B) have superior stability without hygroscopic property, and accordingly they can be preferably used as a raw material of medicaments.
    Type: Application
    Filed: November 25, 2020
    Publication date: June 10, 2021
    Applicants: Kaken Pharmaceutical Co., Ltd., Brickell Biotech, Inc.
    Inventors: Kazuyoshi MARUBAYASHI, Masahito WATANABE, Herbert R. BRINKMAN