Abstract: Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: Provided are an inverting device capable of suppressing a defect caused by wear debris generated by contacting and sliding of clamping members on a substrate with a sealing member, the wear debris being melted when heating the substrate and then adhered thereto after cooling thereof, and a manufacturing method of a liquid crystal display panel using the inverting device. The inverting device includes a main body, an inverting portion, a substrate contact portion, and a substrate support portion. The substrate contact portion and the substrate support portion clamp the substrate, and the inverting portion inverts the substrate. The substrate contact portion and the substrate support portion each have heat-resistant layer with a heat resistance temperature which is equal to or higher than a temperature at which the sealing member is cured by heating.

Abstract: The circumferential part of an opening of an ejection part included in a nozzle head is formed in the shape of a convex curved plane. A liquid crystal droplet adhered to the portion with the shape of a convex curved plane of the ejection part smoothly flows down along the outer surface of the ejection part and is adhered to the opening end of the opening. The liquid crystal droplet adhered to the opening end of the opening is absorbed into the liquid crystal droplet to be ejected through the opening and is dispensed downward together with the liquid crystal droplet. This suppresses a large liquid crystal pool being formed on the outer surface of the ejection part. As a result, such problems that liquid crystal to be dispensed is absorbed into a liquid crystal pool while not being dispensed downward and that a large amount of liquid crystal is unnecessarily dispensed from a liquid crystal pool are both be suppressed. In other words, liquid crystal may appropriately be dispensed.

Abstract: Provided are an inverting device capable of suppressing a defect caused by wear debris generated by contacting and sliding of clamping members on a substrate with a sealing member, the wear debris being melted when heating the substrate and then adhered thereto after cooling thereof, and a manufacturing method of a liquid crystal display panel using the inverting device. The inverting device includes a main body, an inverting portion, a substrate contact portion, and a substrate support portion. The substrate contact portion and the substrate support portion clamp the substrate, and the inverting portion inverts the substrate. The substrate contact portion and the substrate support portion each have heat-resistant layer with a heat resistance temperature which is equal to or higher than a temperature at which the sealing member is cured by heating.

Abstract: The circumferential part of an opening of an ejection part included in a nozzle head is formed in the shape of a convex curved plane. A liquid crystal droplet adhered to the portion with the shape of a convex curved plane of the ejection part smoothly flows down along the outer surface of the ejection part and is adhered to the opening end of the opening. The liquid crystal droplet adhered to the opening end of the opening is absorbed into the liquid crystal droplet to be ejected through the opening and is dispensed downward together with the liquid crystal droplet. This suppresses a large liquid crystal pool being formed on the outer surface of the ejection part. As a result, such problems that liquid crystal to be dispensed is absorbed into a liquid crystal pool while not being dispensed downward and that a large amount of liquid crystal is unnecessarily dispensed from a liquid crystal pool are both be suppressed. In other words, liquid crystal may appropriately be dispensed.

Abstract: A nanobubble-containing liquid producing apparatus includes: a microbubble generating device that prepares a microbubble-containing liquid with use of a liquid introduced into a microbubble generation tank and discharges the microbubble-containing liquid into the microbubble generation tank; a micro-nanobubble generating device that prepares a micro-nanobubble-containing liquid with use of the microbubble-containing liquid introduced into a micro-nanobubble generation tank and discharges the micro-nanobubble-containing liquid into the micro-nanobubble generation tank; and a nanobubble generating device that prepares a nanobubble-containing liquid with use of the micro-nanobubble-containing liquid introduced into a nanobubble generation tank and discharges the nanobubble-containing liquid into the nanobubble generation tank. Therefore, an apparatus for producing a nanobubble-containing liquid with use of general-purpose products can be manufactured at low cost and in a short period of time.

Abstract: In the upper part and the lower part of a micro-nano bubble generation section 34 in a micro-nano bubble bathtub 1, two kinds of micro-nano bubbles different in a size distribution are generated by first and second micro-nano bubble generators (submerged pump-type micro-nano bubble generator 2 and spiral flow-type micro-nano bubble generator 10) of two kinds, so that bathtub water containing micro-nano bubbles in a wide size distribution can be produced in a large amount. Some of the water containing micro-nano bubbles generated in the lower part is thrown into the first micro-nano bubble generator (spiral flow-type micro-nano bubble generator 10) in the upper part, so that the spiral flow-type micro-nano bubble generator 10 can generate micro-nano bubbles in a smaller size. Therefore, in this bathtub, micro-nano bubbles abundant in size and large in amount can be produced economically.

Abstract: In order to provide a device and a method for increasing blood flow and an insulin-like growth factor with use of a large amount of carbonic gas nano bubbles, the device of the present invention includes: a bathtub 1; and a nano bubble-producing section 41 for producing carbonic gas nano bubbles in bath water in the bathtub 1.

Abstract: Drainage water containing an organofluorine compound is introduced into a raw tank (1) and then filtered through a filtration device (4). Next, a microorganism, a micro-nanobubbling auxiliary agent and a nutrient are added thereto in a first transit tank (5) while micro-nanobubbles are generated thereinto by a micro-nanobubbling machine (7), thereby giving treated water. This treated water is then fed into an active carbon column (14) and then the above-described organofluorine compound contained in the treated water is decomposed by the microorganism as described above.

Abstract: In a bioreactor, a culture solution derived from a cultivation tank is separated into bacteria cells and filtrate by a bacteria cell filter. The filtrate is introduced from the bacteria cell filter into a micro-nano bubble generation tank where micro-nano-bubbles are mixed with the filtrate. The filtrate containing micro-nano-bubbles is returned to the cultivation tank to activate the microorganisms therein, so that a biological reaction time is reduced by the activated microorganisms.

Abstract: Water (23) that contains micro-nano bubbles generated in a micro-nano bubble generation tank (6) is introduced and treated in a charcoal water tank (ii) which is filled with a charcoal (15) and in which an air diffusing pipe (12) is placed and thereafter introduced and treated in a membrane device (21). Thus, activities of microorganisms propagating in the charcoal (15) are increased by the micro-nano bubbles, markedly increasing ability of decomposing organic matters in the water. Therefore, a clogging phenomenon due to the organic matters can be prevented by reducing organic loads on the membrane device (21). Moreover, a very small amount of alcohols or salts are added as a micro-nano bubble generation aid to the micro-nano bubble generation tank (6), improving an incidence rate of the micro-nano bubbles. The alcohols and salts are easily decomposed by the charcoal water tank (ii) and easily removed by the membrane device (21).

Abstract: A first treatment tank (1) to a fourth treatment tank are installed prior to ultrapure water production apparatus (5), dilute wastewater recovering apparatus (34), general service water recovering apparatus and wastewater treatment apparatus. The treatment tanks (1, 2, . . . ) each have a micro-nano bubble generation tank (6, 23, . . . ) and an anaerobic measuring tank (7, 24, . . . ). Accordingly, microbes within the respective anaerobic measuring tanks (7, 24, . . . ) are activated by micro-nano bubbles generated in each micro-nano bubble generation tank (6, 23, . . . ) to thereby enhance the treatment efficiency of low-concentration organic matter. Further, when the value measured by dissolved oxygen meter (13, 30, . . . ) or oxidation-reduction potentiometer (14, 31, . . . ) of each anaerobic measuring tank (7, 24, . . . ) exceeds an individually determined given range, the rotational speed of a circulating pump (9, 26, . . . ) is controlled to thereby decrease the generation of micro-nano bubbles.

Abstract: In a waste water treatment apparatus and/or method, waste water containing aminoethanol and dimethyl sulfoxide is introduced into a first denitrification tank within a first waste water treatment apparatus. Malodorous gas generated in the first waste water treatment apparatus is decomposed and treated in a second waste water treatment apparatus where another waste water is treated as another system. The second waste water treatment apparatus has a second nitrification tank including a semi-anaerobic section. The malodorous gas is introduced from the first waste water treatment apparatus into a scrubber. The malodorous gas is treated by sludge which is circulated between the second nitrification tank and the scrubber.

Abstract: A nanobubble-containing liquid producing apparatus includes: a microbubble generating device that prepares a microbubble-containing liquid with use of a liquid introduced into a microbubble generation tank and discharges the microbubble-containing liquid into the microbubble generation tank; a micro-nanobubble generating device that prepares a micro-nanobubble-containing liquid with use of the microbubble-containing liquid introduced into a micro-nanobubble generation tank and discharges the micro-nanobubble-containing liquid into the micro-nanobubble generation tank; and a nanobubble generating device that prepares a nanobubble-containing liquid with use of the micro-nanobubble-containing liquid introduced into a nanobubble generation tank and discharges the nanobubble-containing liquid into the nanobubble generation tank. Therefore, an apparatus for producing a nanobubble-containing liquid with use of general-purpose products can be manufactured at low cost and in a short period of time.

Abstract: Waste gas/wastewater treatment equipment treats waste gas in a scrubber 18 by using micronanobubble water produced in a micronanobubble reaction vessel 31 as washing water. Waste gas is efficiently cleaned by the substance surface high-velocity cleaning function which micronanobubbles have. The washing water having been used in the waste gas treatment is reused in wastewater treatment in adjustment tank 1, denitrification tank 3 and nitrification tank 11 which constitute a wastewater treatment section. Thus, the micronanobubbles contained in the washing water are utilized in wastewater treatment, so that efficiency of wastewater treatment is enhanced.

Abstract: In a water treatment system, micro-nano bubbles are used in a production device and a detoxification device as one example of the upstream treatment devices which perform specified treatment with use of water. The micro-nano bubbles are used again in the waste water treatment by a waste water pretreatment device and a waste water treatment device in the subsequent step. Since the micro-nano bubbles are reused, the efficiency of the micro-nano bubbles can be enhanced. Moreover, according to the waste water pretreatment device, treatment water is pretreated with the microorganisms activated by micro-nano bubbles and propagating in a polyvinylidene chloride filler material and then it is introduced into the waste water treatment device in the subsequent step. Thereby it is possible to reduce the waste water treatment load in the waste water treatment device in the subsequent step.

Abstract: In a micronanobubble reaction vessel 3 of wastewater treatment equipment, wastewater containing organic matter is treated with micronanobubbles. Thereafter, the wastewater is introduced into an aeration tank 7. Part of organic matter in the wastewater is oxidized in the micronanobubble reaction vessel 3 by micronanobubble treatment prior to treatment with activity of microorganisms enhanced in the aeration tank 7. After organic matter load is thus reduced, the treatment water is introduced into the aeration tank 7, in which microorganisms exist in high concentration due to submerged membranes 17, so that the organic matter in wastewater can be effectively treated. This makes it possible to accomplish miniaturization of the aeration tank 7, reduction in scale of the whole equipment and therefore reduction in initial cost.

Abstract: A waster water treatment apparatus has micro-nano bubbles generation tanks, mixing tanks, a submerged membrane tank, a contact oxidation tank, and an activated charcoal adsorption device. In the micro-nano bubbles generation tanks, micro-nano bubbles are added to the waste water. In the mixing tanks, the waste water containing micro-nano bubbles is mixed with sludge containing microorganisms. In the contact oxidation tank, the waste water containing organofluoric compounds is microbially treated by the micro-nano bubbles added to the waste water. The micro-nano bubbles activate microorganisms in the waste water. Thereby organofluoric compounds are microbially decomposed with effect.

Abstract: A water treatment equipment has a raw water tank as a mixing section, a micronanobubble generation tank, a floatation tank, and a treated water tank. Waste water as treatment water is introduced into the raw water tank and mixed with the water containing micronanobubbles produced by the micronanobubble generation tank. Thereafter, the waste water, as treatment water, is introduced into a lower mixing section of the floatation tank from the raw tank by a raw water tank pump. Also, treatment water containing fine bubbles is introduced into the lower mixing section from a pressure tank. Therefore, the micronanobubbles is mixed with the fine bubbles in the lower mixing section of the floatation tank, thereby almost all the suspended matter in the treatment water is surfaced. Thus, the water treatment equipment enhances separatability of suspended matter.

Abstract: The application device for liquid containing micro-nano bubbles generates micro-nano bubbles in a wide size distribution with use of a submerged pump-type micro-nano bubble generator and a spiral flow-type micro-nano bubble generator. A micro-nano bubble generating aid metering pump is controlled by a bubble level meter and a level controller, so that the supply amount of a micro-nano bubble generating aid is controlled in response to the level of bubbles from a fluid level. The supply amount of a micro-nano bubble generating aid is also controlled by a turbidimeter and a controller in response to the turbidity of the liquid in a micro-nano bubble generation tank, while the amount of air supplied to the submerged pump-type micro-nano bubble generator is controlled in response to the turbidity of the liquid. Therefore, the device can produce a large amount of various micro-nano bubbles in a wide size distribution more economically.